PL4380932T3 - Sposób wytwarzania aficamtenu - Google Patents
Sposób wytwarzania aficamtenuInfo
- Publication number
- PL4380932T3 PL4380932T3 PL22761878.2T PL22761878T PL4380932T3 PL 4380932 T3 PL4380932 T3 PL 4380932T3 PL 22761878 T PL22761878 T PL 22761878T PL 4380932 T3 PL4380932 T3 PL 4380932T3
- Authority
- PL
- Poland
- Prior art keywords
- aficamten
- preparing
- preparing aficamten
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/06—Sulfinamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Plural Heterocyclic Compounds (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163203888P | 2021-08-03 | 2021-08-03 | |
| PCT/US2022/074427 WO2023015184A1 (en) | 2021-08-03 | 2022-08-02 | Process for preparing aficamten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4380932T3 true PL4380932T3 (pl) | 2026-05-11 |
Family
ID=83149173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL22761878.2T PL4380932T3 (pl) | 2021-08-03 | 2022-08-02 | Sposób wytwarzania aficamtenu |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11932631B2 (pl) |
| EP (1) | EP4380932B1 (pl) |
| JP (1) | JP2024530111A (pl) |
| KR (1) | KR20240047360A (pl) |
| CN (1) | CN117813304A (pl) |
| AR (1) | AR126681A1 (pl) |
| AU (1) | AU2022325141A1 (pl) |
| CA (1) | CA3224971A1 (pl) |
| CL (1) | CL2024000264A1 (pl) |
| ES (1) | ES3062809T3 (pl) |
| HR (1) | HRP20251575T1 (pl) |
| IL (1) | IL310592A (pl) |
| MA (1) | MA65713B1 (pl) |
| MD (1) | MD4380932T2 (pl) |
| MX (1) | MX2024001294A (pl) |
| PL (1) | PL4380932T3 (pl) |
| RS (1) | RS67658B1 (pl) |
| SM (1) | SMT202600028T1 (pl) |
| TW (1) | TW202315619A (pl) |
| WO (1) | WO2023015184A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117964573B (zh) | 2018-01-19 | 2026-04-14 | 赛特凯恩蒂克公司 | 作为心肌节抑制剂的二氢苯并呋喃和茚类似物 |
| RS65611B1 (sr) * | 2019-07-17 | 2024-07-31 | Cytokinetics Inc | Polimorfi (r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1-il)-1-metil-1h- pir azole-4-karboksamida |
| US20230058927A1 (en) | 2021-07-16 | 2023-02-23 | Cytokinetics, Inc. | Methods for treating hypertrophic cardiomyopathy |
| ES3062809T3 (en) | 2021-08-03 | 2026-04-14 | Cytokinetics Inc | Process for preparing aficamten |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060173183A1 (en) | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
| US20070155737A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20080021024A1 (en) | 2006-06-29 | 2008-01-24 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors |
| CA2670083A1 (en) | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
| EP2460787A1 (en) | 2007-07-03 | 2012-06-06 | Astellas Pharma Inc. | Amide compounds and their use as PGE2 antagonists. |
| TW201920108A (zh) | 2017-09-25 | 2019-06-01 | 日商武田藥品工業有限公司 | N-(氰基取代之苄基或吡啶基甲基)-3-羥基吡啶醯胺衍生物 |
| CN117964573B (zh) | 2018-01-19 | 2026-04-14 | 赛特凯恩蒂克公司 | 作为心肌节抑制剂的二氢苯并呋喃和茚类似物 |
| RS65611B1 (sr) | 2019-07-17 | 2024-07-31 | Cytokinetics Inc | Polimorfi (r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1-il)-1-metil-1h- pir azole-4-karboksamida |
| GB202102088D0 (en) | 2021-02-15 | 2021-03-31 | Mironid Ltd | Compounds and their use as pde4 activators |
| CN114835687B (zh) | 2021-04-02 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂 |
| ES3062809T3 (en) | 2021-08-03 | 2026-04-14 | Cytokinetics Inc | Process for preparing aficamten |
| CN115093400B (zh) | 2021-09-18 | 2023-09-05 | 北京华森英诺生物科技有限公司 | AhR抑制剂及其用途和制备方法 |
| WO2024134498A1 (en) | 2022-12-22 | 2024-06-27 | Assia Chemical Industries Ltd. | Solid state forms of aficamten and process for preparation thereof |
| WO2024182469A1 (en) | 2023-02-28 | 2024-09-06 | MyoKardia, Inc. | Myosin inhibitors for use in the treatment of hypertrophic cardiomyopathy |
| CN120712262A (zh) | 2023-03-02 | 2025-09-26 | 苏州科睿思制药有限公司 | Aficamten的共晶及其制备方法和用途 |
-
2022
- 2022-08-02 ES ES22761878T patent/ES3062809T3/es active Active
- 2022-08-02 AU AU2022325141A patent/AU2022325141A1/en active Pending
- 2022-08-02 CA CA3224971A patent/CA3224971A1/en active Pending
- 2022-08-02 HR HRP20251575TT patent/HRP20251575T1/hr unknown
- 2022-08-02 TW TW111128967A patent/TW202315619A/zh unknown
- 2022-08-02 WO PCT/US2022/074427 patent/WO2023015184A1/en not_active Ceased
- 2022-08-02 EP EP22761878.2A patent/EP4380932B1/en active Active
- 2022-08-02 MA MA65713A patent/MA65713B1/fr unknown
- 2022-08-02 JP JP2024501160A patent/JP2024530111A/ja active Pending
- 2022-08-02 RS RS20260038A patent/RS67658B1/sr unknown
- 2022-08-02 US US17/816,898 patent/US11932631B2/en active Active
- 2022-08-02 CN CN202280052124.7A patent/CN117813304A/zh active Pending
- 2022-08-02 AR ARP220102067A patent/AR126681A1/es unknown
- 2022-08-02 MX MX2024001294A patent/MX2024001294A/es unknown
- 2022-08-02 SM SM20260028T patent/SMT202600028T1/it unknown
- 2022-08-02 KR KR1020247003239A patent/KR20240047360A/ko active Pending
- 2022-08-02 MD MDE20240610T patent/MD4380932T2/ro unknown
- 2022-08-02 IL IL310592A patent/IL310592A/en unknown
- 2022-08-02 PL PL22761878.2T patent/PL4380932T3/pl unknown
-
2023
- 2023-09-15 US US18/468,636 patent/US12247024B2/en active Active
-
2024
- 2024-01-29 CL CL2024000264A patent/CL2024000264A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA65713B1 (fr) | 2026-01-30 |
| TW202315619A (zh) | 2023-04-16 |
| US11932631B2 (en) | 2024-03-19 |
| US12247024B2 (en) | 2025-03-11 |
| EP4380932B1 (en) | 2025-11-26 |
| US20230045450A1 (en) | 2023-02-09 |
| US20240150336A1 (en) | 2024-05-09 |
| MX2024001294A (es) | 2024-02-13 |
| SMT202600028T1 (it) | 2026-03-09 |
| AR126681A1 (es) | 2023-11-01 |
| EP4380932C0 (en) | 2025-11-26 |
| ES3062809T3 (en) | 2026-04-14 |
| MD4380932T2 (ro) | 2026-04-30 |
| EP4380932A1 (en) | 2024-06-12 |
| AU2022325141A1 (en) | 2024-02-08 |
| HRP20251575T1 (hr) | 2026-01-30 |
| CA3224971A1 (en) | 2023-02-09 |
| IL310592A (en) | 2024-04-01 |
| WO2023015184A1 (en) | 2023-02-09 |
| CL2024000264A1 (es) | 2024-08-16 |
| CN117813304A (zh) | 2024-04-02 |
| KR20240047360A (ko) | 2024-04-12 |
| JP2024530111A (ja) | 2024-08-16 |
| RS67658B1 (sr) | 2026-02-27 |
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