PL4347575T3 - Związki benzotio(di)azepinowe i ich zastosowanie jako modulatorów kwasów żółciowych - Google Patents

Związki benzotio(di)azepinowe i ich zastosowanie jako modulatorów kwasów żółciowych

Info

Publication number
PL4347575T3
PL4347575T3 PL22732489.4T PL22732489T PL4347575T3 PL 4347575 T3 PL4347575 T3 PL 4347575T3 PL 22732489 T PL22732489 T PL 22732489T PL 4347575 T3 PL4347575 T3 PL 4347575T3
Authority
PL
Poland
Prior art keywords
benzothia
bile acid
acid modulators
azepine compounds
azepine
Prior art date
Application number
PL22732489.4T
Other languages
English (en)
Inventor
Per-Göran Gillberg
Ingemar Starke
Santosh S. Kulkarni
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of PL4347575T3 publication Critical patent/PL4347575T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
PL22732489.4T 2021-06-03 2022-06-03 Związki benzotio(di)azepinowe i ich zastosowanie jako modulatorów kwasów żółciowych PL4347575T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN202111024711 2021-06-03
PCT/EP2022/065165 WO2022253997A1 (en) 2021-06-03 2022-06-03 Benzothia(di)azepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
PL4347575T3 true PL4347575T3 (pl) 2025-10-06

Family

ID=82156361

Family Applications (1)

Application Number Title Priority Date Filing Date
PL22732489.4T PL4347575T3 (pl) 2021-06-03 2022-06-03 Związki benzotio(di)azepinowe i ich zastosowanie jako modulatorów kwasów żółciowych

Country Status (19)

Country Link
US (1) US12365658B2 (pl)
EP (1) EP4347575B1 (pl)
JP (1) JP2024520677A (pl)
KR (1) KR20240017844A (pl)
CN (1) CN117412955A (pl)
AR (1) AR126076A1 (pl)
AU (1) AU2022285893A1 (pl)
BR (1) BR112023024850A2 (pl)
CA (1) CA3218474A1 (pl)
CL (1) CL2023003568A1 (pl)
CO (1) CO2023016072A2 (pl)
ES (1) ES3037404T3 (pl)
HU (1) HUE072404T2 (pl)
IL (1) IL308582A (pl)
MX (1) MX2023014153A (pl)
PL (1) PL4347575T3 (pl)
TW (1) TW202313579A (pl)
WO (1) WO2022253997A1 (pl)
ZA (1) ZA202400117B (pl)

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US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
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US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
EP3921028B1 (en) 2019-02-06 2022-11-09 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
JP7696898B2 (ja) 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
PE20230234A1 (es) 2019-12-04 2023-02-07 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores del acido biliar
EP4069361B1 (en) 2019-12-04 2024-01-03 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
EP4243831A1 (en) 2020-11-12 2023-09-20 Albireo AB Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
CA3198216A1 (en) 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
CN119053330A (zh) 2022-04-22 2024-11-29 阿尔比里奥公司 皮下给药asbt抑制剂
WO2023237728A1 (en) 2022-06-09 2023-12-14 Albireo Ab Treating hepatitis
AU2024224261A1 (en) * 2023-02-20 2025-09-04 Assembly Biosciences, Inc. Benzothia(dia)zepine compounds for treatment of hbv and hdv
TW202500157A (zh) * 2023-05-25 2025-01-01 大陸商正大天晴藥業集團股份有限公司 一種苯並噻二氮卓化合物及其用途
WO2025043094A1 (en) 2023-08-23 2025-02-27 Assembly Biosciences, Inc. Benzothia(dia)zepine compounds for treatment of hbv and hdv
WO2025146508A1 (en) 2024-01-05 2025-07-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
WO2025146507A1 (en) 2024-01-05 2025-07-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators

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