PL428753A1 - Method of preparing 4'-hydroxy-5,7-dimethoxyflavone - Google Patents

Method of preparing 4'-hydroxy-5,7-dimethoxyflavone

Info

Publication number
PL428753A1
PL428753A1 PL428753A PL42875319A PL428753A1 PL 428753 A1 PL428753 A1 PL 428753A1 PL 428753 A PL428753 A PL 428753A PL 42875319 A PL42875319 A PL 42875319A PL 428753 A1 PL428753 A1 PL 428753A1
Authority
PL
Poland
Prior art keywords
dimethoxyflavone
hydroxy
preparing
microorganism
strain
Prior art date
Application number
PL428753A
Other languages
Polish (pl)
Other versions
PL238964B1 (en
Inventor
Mateusz Łużny
Ewa Kozłowska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL428753A priority Critical patent/PL238964B1/en
Publication of PL428753A1 publication Critical patent/PL428753A1/en
Publication of PL238964B1 publication Critical patent/PL238964B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Wynalazek dotyczy sposobu wytwarzania 4'-hydroksy-5,7-dimetoksyflawonu o wzorze 2. W wyniku działania układu enzymatycznego zawartego w komórkach szczepu Isaria fumosorosea KCh J2, następuje O-demetylacja. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (octan etylu).The invention relates to a process for the preparation of 4'-hydroxy-5,7-dimethoxyflavone of the formula 2. As a result of the enzyme system contained in the cells of the Isaria fumosorosea KCh J2 strain, O-demethylation occurs. The product obtained in this way is separated from the aqueous culture of the microorganism by a known method by extraction with a water-immiscible organic solvent (ethyl acetate).

PL428753A 2019-01-31 2019-01-31 Method of preparing 4'-hydroxy-5,7-dimethoxyflavone PL238964B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL428753A PL238964B1 (en) 2019-01-31 2019-01-31 Method of preparing 4'-hydroxy-5,7-dimethoxyflavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL428753A PL238964B1 (en) 2019-01-31 2019-01-31 Method of preparing 4'-hydroxy-5,7-dimethoxyflavone

Publications (2)

Publication Number Publication Date
PL428753A1 true PL428753A1 (en) 2020-08-10
PL238964B1 PL238964B1 (en) 2021-10-25

Family

ID=71943635

Family Applications (1)

Application Number Title Priority Date Filing Date
PL428753A PL238964B1 (en) 2019-01-31 2019-01-31 Method of preparing 4'-hydroxy-5,7-dimethoxyflavone

Country Status (1)

Country Link
PL (1) PL238964B1 (en)

Also Published As

Publication number Publication date
PL238964B1 (en) 2021-10-25

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