PL426985A1 - 3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone - Google Patents

3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone

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Publication number
PL426985A1
PL426985A1 PL426985A PL42698518A PL426985A1 PL 426985 A1 PL426985 A1 PL 426985A1 PL 426985 A PL426985 A PL 426985A PL 42698518 A PL42698518 A PL 42698518A PL 426985 A1 PL426985 A1 PL 426985A1
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PL
Poland
Prior art keywords
flavanone
methylglucopyranosyl
hydroxy
hours
organic solvent
Prior art date
Application number
PL426985A
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Polish (pl)
Other versions
PL237708B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL426985A priority Critical patent/PL237708B1/en
Publication of PL426985A1 publication Critical patent/PL426985A1/en
Publication of PL237708B1 publication Critical patent/PL237708B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest związek o nazwie 3'-hydroksy-4'-O-ß-D-(4"-O-metyloglukopiranozylo)-flawanon i sposób wytwarzania 3'-hydroksy-4'-O-ß-D-(4"-O-metyloglukopiranozylo)-flawanonu. Sposób ten polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2. Po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 4'-metoksyflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu co najmniej 96 godzin. Kolejno produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is a compound named 3'-hydroxy-4'-O-ß-D- (4 "-O-methylglucopyranosyl) -flavanone and a method for the preparation of 3'-hydroxy-4'-O-ß-D- (4" -O-methylglucopyranosyl) flavanone. The method consists in introducing the Isaria fumosorosea KCH J2 strain into a medium suitable for filamentous fungi. After at least 72 hours, the substrate is introduced into the culture, which is 4'-methoxy flavanone of the formula I, dissolved in a water-miscible organic solvent. The transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours. Subsequently, the product is extracted with a water-immiscible organic solvent and purified by chromatography.

PL426985A 2018-09-10 2018-09-10 3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone PL237708B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426985A PL237708B1 (en) 2018-09-10 2018-09-10 3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426985A PL237708B1 (en) 2018-09-10 2018-09-10 3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone

Publications (2)

Publication Number Publication Date
PL426985A1 true PL426985A1 (en) 2020-03-23
PL237708B1 PL237708B1 (en) 2021-05-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL426985A PL237708B1 (en) 2018-09-10 2018-09-10 3'-Hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone and method of preparing 3'-hydroxy-4'-O-β-D-(4"-O-methylglucopyranosyl)-flavanone

Country Status (1)

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PL (1) PL237708B1 (en)

Also Published As

Publication number Publication date
PL237708B1 (en) 2021-05-17

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