PL426974A1 - 6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone - Google Patents

6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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Publication number
PL426974A1
PL426974A1 PL426974A PL42697418A PL426974A1 PL 426974 A1 PL426974 A1 PL 426974A1 PL 426974 A PL426974 A PL 426974A PL 42697418 A PL42697418 A PL 42697418A PL 426974 A1 PL426974 A1 PL 426974A1
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PL
Poland
Prior art keywords
flavone
methoxy
methylglucopyranosyl
hours
formula
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Application number
PL426974A
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Polish (pl)
Other versions
PL237703B1 (en
Inventor
Monika Dymarska
Edyta Kostrzewa-Susłow
Tomasz Janeczko
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL426974A priority Critical patent/PL237703B1/en
Publication of PL426974A1 publication Critical patent/PL426974A1/en
Publication of PL237703B1 publication Critical patent/PL237703B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem zgłoszenia jest 6-metoksy-3'-O-ß-D-(4"-O-metyloglukopiranozylo)-flawon i sposób wytwarzania 6-metoksy-3'-O-ß-D-(4"-O-metyloglukopiranozylo)-flawonu o wzorze 2. Powyższy sposób polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2. Po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 6-metoksyflawon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu co najmniej 96 godzin. Kolejno produkt ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The subject of the application is 6-methoxy-3'-O-ß-D- (4 "-O-methylglucopyranosyl) -flavone and a process for the preparation of 6-methoxy-3'-O-ß-D- (4" -O-methylglucopyranosyl) a flavone of formula 2. The above method consists in introducing the strain Isaria fumosorosea KCH J2 into a medium suitable for filamentous fungi. After at least 72 hours, the substrate is introduced into the culture, which is 6-methoxy flavone of the formula I, dissolved in a water-miscible organic solvent. The transformation is carried out at a temperature of 20 to 30 degrees Celsius with continuous shaking for at least 96 hours. Subsequently, the product is extracted with a water-immiscible organic solvent and purified by chromatography.

PL426974A 2018-09-10 2018-09-10 6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone PL237703B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426974A PL237703B1 (en) 2018-09-10 2018-09-10 6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426974A PL237703B1 (en) 2018-09-10 2018-09-10 6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

Publications (2)

Publication Number Publication Date
PL426974A1 true PL426974A1 (en) 2020-03-23
PL237703B1 PL237703B1 (en) 2021-05-17

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PL426974A PL237703B1 (en) 2018-09-10 2018-09-10 6-Methoxy-3'-O-β-D- (4''-O-methylglucopyranosyl)-flavone and method of preparing 6-methoxy-3'-O-β-D-(4''-O-methylglucopyranosyl)-flavone

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PL (1) PL237703B1 (en)

Also Published As

Publication number Publication date
PL237703B1 (en) 2021-05-17

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