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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
Rozwiązanie polega na tym, że do podłoża odpowiedniego dla grzybów strzępkowych wprowadza się szczep Isaria fumosorosea KCH J2. Po upływie co najmniej 72 godzin do hodowli wprowadza się substrat, którym jest 7-hydroksyflawanon o wzorze 1, rozpuszczony w rozpuszczalniku organicznym mieszającym się z wodą. Transformację prowadzi się w temperaturze od 20 do 30 stopni Celsjusza, przy ciągłym wstrząsaniu co najmniej przez 96 godzin. Produkt o wzorze 2 ekstrahuje się rozpuszczalnikiem organicznym niemieszającym się z wodą i oczyszcza chromatograficznie.The solution is that the Isaria fumosorosea KCH J2 strain is introduced into the medium suitable for filamentous fungi. After at least 72 hours, a substrate, which is 7-hydroxyflavanone of formula 1, dissolved in a water-miscible organic solvent is introduced into the culture. Transformation is carried out at a temperature of 20-30 degrees Celsius, with constant shaking for at least 96 hours. The product of Formula 2 is extracted with a water-immiscible organic solvent and purified by chromatography.
PL417789A2016-06-302016-06-30Method for producing 7-O-β-D-4"-methoxyglucopiranosil flavanone
PL234610B1
(en)
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