PL426819A1 - Method of producing polylactide spongy bone substitute with increased hydrophilicity - Google Patents
Method of producing polylactide spongy bone substitute with increased hydrophilicityInfo
- Publication number
- PL426819A1 PL426819A1 PL426819A PL42681918A PL426819A1 PL 426819 A1 PL426819 A1 PL 426819A1 PL 426819 A PL426819 A PL 426819A PL 42681918 A PL42681918 A PL 42681918A PL 426819 A1 PL426819 A1 PL 426819A1
- Authority
- PL
- Poland
- Prior art keywords
- polylactide
- solution
- spongy bone
- bone substitute
- increased hydrophilicity
- Prior art date
Links
Landscapes
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób wytwarzania polilaktydowego substytutu kości gąbczastej o zwiększonej hydrofilowości, w którym sporządza się roztwór polilaktydu w dioksanie o stężeniu 1 - 12%, do tego roztworu dodaje się kopolimer kwasu metakrylowego w ilości 0,01 - 100% masowych w stosunku do polilaktydu, po czym dodaje się porofor, wybrany spośród wody i alkoholu C1 - C3, w ilości 0,1 - 30% objętościowych w stosunku do roztworu polimeru, mieszaninę miesza się przez 3 - 24 h w temperaturze 20 - 60°C, z szybkością 160 - 300 rpm, po czym roztwór wylewa się do formy i zmraża się w temperaturze -25- -35°C, przez 12 - 36 h, następnie otrzymany substytut pozostawia się w wodzie, o temperaturze -10°C- 10°C na 3 - 5 dni, po czym suszy się próżniowo w temperaturze 30 - 45°C przez 24 - 48 h.The subject of the application is a method of producing polylactide spongy bone substitute with increased hydrophilicity, in which a solution of polylactide in dioxane is prepared at a concentration of 1 - 12%, a methacrylic acid copolymer is added to this solution in an amount of 0.01 - 100% by mass in relation to polylactide, then a blowing agent selected from water and C1 - C3 alcohol is added in an amount of 0.1 - 30% by volume with respect to the polymer solution, the mixture is stirred for 3 - 24 hours at 20 - 60 ° C, at a rate of 160 - 300 rpm, then the solution is poured into a mold and frozen at -25-35 ° C for 12-36 h, then the obtained substitute is left in water at -10 ° C-10 ° C for 3 - 5 days, then vacuum dried at 30-45 ° C for 24-48 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426819A PL236857B1 (en) | 2018-08-27 | 2018-08-27 | Method of producing polylactide spongy bone substitute with increased hydrophilicity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL426819A PL236857B1 (en) | 2018-08-27 | 2018-08-27 | Method of producing polylactide spongy bone substitute with increased hydrophilicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL426819A1 true PL426819A1 (en) | 2020-03-09 |
| PL236857B1 PL236857B1 (en) | 2021-02-22 |
Family
ID=69709524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL426819A PL236857B1 (en) | 2018-08-27 | 2018-08-27 | Method of producing polylactide spongy bone substitute with increased hydrophilicity |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL236857B1 (en) |
-
2018
- 2018-08-27 PL PL426819A patent/PL236857B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL236857B1 (en) | 2021-02-22 |
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