PL422072A1 - Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 - Google Patents
Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1Info
- Publication number
- PL422072A1 PL422072A1 PL422072A PL42207217A PL422072A1 PL 422072 A1 PL422072 A1 PL 422072A1 PL 422072 A PL422072 A PL 422072A PL 42207217 A PL42207217 A PL 42207217A PL 422072 A1 PL422072 A1 PL 422072A1
- Authority
- PL
- Poland
- Prior art keywords
- palmitic acid
- containing ibuprofen
- phosphatidylcholine containing
- obtaining
- phosphocholine
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1 oraz resztę kwasu palmitynowego w pozycji sn-2 o wzorze 2, polegający na tym, że 1-[2'-(4"-izobutylofenylo)]propanoilo-2-hydroksy-sn-glicero-3-fosfocholinę poddaje się estryfikacji kwasem palmitynowym w bezwodnym chlorku metylenu albo chloroformie, z udziałem dwukrotnego nadmiaru molowego N,N-dicykloheksylokarbodiimidu w stosunku do kwasu palmitynowego oraz w obecności 4-N,N-dimetyloamino)pirydyny, otrzymując 1-[2'-(4"-izobutylofenylo)]propanoilo-2-palmitoilo-sn-glicero-3-fosfocholinę.The subject of the application is a method for obtaining phosphatidylcholine containing ibuprofen in the sn-1 position and a palmitic acid residue in the sn-2 position of formula 2, consisting in that 1- [2 '- (4 "-isobutylphenyl)] propanoyl-2-hydroxy- sn-glycerol-3-phosphocholine is subjected to esterification with palmitic acid in anhydrous methylene chloride or chloroform, with a double molar excess of N, N-dicyclohexylcarbodiimide relative to palmitic acid and in the presence of 4-N, N-dimethylamino) pyridine [2 '- (4 "-izobutylofenylo)] propanoyl-2-palmitoyl-sn-glycero-3-phosphocholine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422072A PL232298B1 (en) | 2017-06-30 | 2017-06-30 | Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL422072A PL232298B1 (en) | 2017-06-30 | 2017-06-30 | Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 |
Publications (2)
Publication Number | Publication Date |
---|---|
PL422072A1 true PL422072A1 (en) | 2019-01-02 |
PL232298B1 PL232298B1 (en) | 2019-06-28 |
Family
ID=64899047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL422072A PL232298B1 (en) | 2017-06-30 | 2017-06-30 | Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL232298B1 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161519A2 (en) * | 1984-05-15 | 1985-11-21 | Chemie Linz Aktiengesellschaft | Derivatives of glycerophosphocholine and of glycerophosphoethanol amine, their preparation and use |
JP2000281688A (en) * | 1999-03-29 | 2000-10-10 | Nof Corp | Production of mixed acid-type 1,2-diacyl-3- glycerophospholipid |
WO2002090560A2 (en) * | 2001-05-03 | 2002-11-14 | Enzymotec Ltd. | Process for the production of phospholipids |
PL415744A1 (en) * | 2016-01-11 | 2016-08-01 | Uniwersytet Przyrodniczy we Wrocławiu | 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it |
PL419199A1 (en) * | 2016-10-21 | 2017-02-27 | Uniwersytet Przyrodniczy we Wrocławiu | 1'-(3,7,11,15-Tetramethyl-3-vinylhexadecyl)-2'-hydroxy-sn-glycero-3'-phosphatidylcholine and method for obtaining it |
-
2017
- 2017-06-30 PL PL422072A patent/PL232298B1/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0161519A2 (en) * | 1984-05-15 | 1985-11-21 | Chemie Linz Aktiengesellschaft | Derivatives of glycerophosphocholine and of glycerophosphoethanol amine, their preparation and use |
JP2000281688A (en) * | 1999-03-29 | 2000-10-10 | Nof Corp | Production of mixed acid-type 1,2-diacyl-3- glycerophospholipid |
WO2002090560A2 (en) * | 2001-05-03 | 2002-11-14 | Enzymotec Ltd. | Process for the production of phospholipids |
PL415744A1 (en) * | 2016-01-11 | 2016-08-01 | Uniwersytet Przyrodniczy we Wrocławiu | 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it |
PL419199A1 (en) * | 2016-10-21 | 2017-02-27 | Uniwersytet Przyrodniczy we Wrocławiu | 1'-(3,7,11,15-Tetramethyl-3-vinylhexadecyl)-2'-hydroxy-sn-glycero-3'-phosphatidylcholine and method for obtaining it |
Also Published As
Publication number | Publication date |
---|---|
PL232298B1 (en) | 2019-06-28 |
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