PL422073A1 - Phosphatidylcholines and method for obtaining them - Google Patents

Phosphatidylcholines and method for obtaining them

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Publication number
PL422073A1
PL422073A1 PL422073A PL42207317A PL422073A1 PL 422073 A1 PL422073 A1 PL 422073A1 PL 422073 A PL422073 A PL 422073A PL 42207317 A PL42207317 A PL 42207317A PL 422073 A1 PL422073 A1 PL 422073A1
Authority
PL
Poland
Prior art keywords
obtaining
lyso
phosphocholine
propanoyl
application
Prior art date
Application number
PL422073A
Other languages
Polish (pl)
Other versions
PL232663B1 (en
Inventor
Marek Kłobucki
Aleksandra Grudniewska
Bartosz Kocbach
Gabriela Maciejewska
Maciej Ugorski
Czesław Wawrzeńczyk
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL422073A priority Critical patent/PL232663B1/en
Publication of PL422073A1 publication Critical patent/PL422073A1/en
Publication of PL232663B1 publication Critical patent/PL232663B1/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Przedmiotem zgłoszenia są pochodne fosfatydylocholiny, zawierające w pozycji sn-1 naproksen albo ketoprofen oraz resztę kwasu palmitynowego w pozycji sn-2. Zgłoszenie obejmuje też sposób otrzymywania pochodnych fosfatydylocholiny, który polega na tym, że 1-[2'-(6"-metoksynaftalenylo)]propanoilo-2-lizo-sn-glicero-3-fosfocholinę albo 1-[2'-(3"-benzoilofenylo)]propanoilo-2-lizo-sn-glicero-3-fosfocholinę poddaje się estryfikacji kwasem palmitynowym w bezwodnym rozpuszczalniku, z udziałem N,N'-dicykloheksylokarbodiimidu w obecności 4-(N,N-dimetyloamino)pirydyny.The subject of the application are phosphatidylcholine derivatives containing naproxen or ketoprofen in the sn-1 position and a palmitic acid residue in the sn-2 position. The application also includes a method for obtaining phosphatidylcholine derivatives, which consists in the fact that 1- [2 '- (6 "-methoxynaphthalenyl)] propanoyl-2-lyso-sn-glycero-3-phosphocholine or 1- [2' - (3" -benzoylphenyl)] propanoyl-2-lyso-sn-glycerol-3-phosphocholine is subjected to esterification with palmitic acid in an anhydrous solvent, with the participation of N, N'-dicyclohexylcarbodiimide in the presence of 4- (N, N-dimethylamino) pyridine.

PL422073A 2017-06-30 2017-06-30 Phosphatidylcholines and method for obtaining them PL232663B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL422073A PL232663B1 (en) 2017-06-30 2017-06-30 Phosphatidylcholines and method for obtaining them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL422073A PL232663B1 (en) 2017-06-30 2017-06-30 Phosphatidylcholines and method for obtaining them

Publications (2)

Publication Number Publication Date
PL422073A1 true PL422073A1 (en) 2019-01-02
PL232663B1 PL232663B1 (en) 2019-07-31

Family

ID=64899048

Family Applications (1)

Application Number Title Priority Date Filing Date
PL422073A PL232663B1 (en) 2017-06-30 2017-06-30 Phosphatidylcholines and method for obtaining them

Country Status (1)

Country Link
PL (1) PL232663B1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161519A2 (en) * 1984-05-15 1985-11-21 Chemie Linz Aktiengesellschaft Derivatives of glycerophosphocholine and of glycerophosphoethanol amine, their preparation and use
JP2000281688A (en) * 1999-03-29 2000-10-10 Nof Corp Production of mixed acid-type 1,2-diacyl-3- glycerophospholipid
WO2002090560A2 (en) * 2001-05-03 2002-11-14 Enzymotec Ltd. Process for the production of phospholipids
PL415744A1 (en) * 2016-01-11 2016-08-01 Uniwersytet Przyrodniczy we Wrocławiu 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it
PL419199A1 (en) * 2016-10-21 2017-02-27 Uniwersytet Przyrodniczy we Wrocławiu 1'-(3,7,11,15-Tetramethyl-3-vinylhexadecyl)-2'-hydroxy-sn-glycero-3'-phosphatidylcholine and method for obtaining it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161519A2 (en) * 1984-05-15 1985-11-21 Chemie Linz Aktiengesellschaft Derivatives of glycerophosphocholine and of glycerophosphoethanol amine, their preparation and use
JP2000281688A (en) * 1999-03-29 2000-10-10 Nof Corp Production of mixed acid-type 1,2-diacyl-3- glycerophospholipid
WO2002090560A2 (en) * 2001-05-03 2002-11-14 Enzymotec Ltd. Process for the production of phospholipids
PL415744A1 (en) * 2016-01-11 2016-08-01 Uniwersytet Przyrodniczy we Wrocławiu 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it
PL419199A1 (en) * 2016-10-21 2017-02-27 Uniwersytet Przyrodniczy we Wrocławiu 1'-(3,7,11,15-Tetramethyl-3-vinylhexadecyl)-2'-hydroxy-sn-glycero-3'-phosphatidylcholine and method for obtaining it

Also Published As

Publication number Publication date
PL232663B1 (en) 2019-07-31

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