PL415744A1 - 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it - Google Patents
1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining itInfo
- Publication number
- PL415744A1 PL415744A1 PL415744A PL41574416A PL415744A1 PL 415744 A1 PL415744 A1 PL 415744A1 PL 415744 A PL415744 A PL 415744A PL 41574416 A PL41574416 A PL 41574416A PL 415744 A1 PL415744 A1 PL 415744A1
- Authority
- PL
- Poland
- Prior art keywords
- phosphocholine
- anisoyl
- glycero
- hydroxy
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- HLGNMUXIAIBAID-OAHLLOKOSA-N C[N+](C)(C)CCOP([O-])(OC[C@@H](COC(C(C=C1)=CC=C1OC)=O)OO)=O Chemical compound C[N+](C)(C)CCOP([O-])(OC[C@@H](COC(C(C=C1)=CC=C1OC)=O)OO)=O HLGNMUXIAIBAID-OAHLLOKOSA-N 0.000 title 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 abstract 2
- JGFBRKRYDCGYKD-UHFFFAOYSA-N dibutyl(oxo)tin Chemical compound CCCC[Sn](=O)CCCC JGFBRKRYDCGYKD-UHFFFAOYSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- MXMOTZIXVICDSD-UHFFFAOYSA-N anisoyl chloride Chemical compound COC1=CC=C(C(Cl)=O)C=C1 MXMOTZIXVICDSD-UHFFFAOYSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Wynalazek dotyczy fosfolipidowej pochodnej kwasu anyżowego, o wzorze 1 oraz sposobu jej otrzymywania na drodze reakcji sn-glicero-3-fosfocholiny (GPC) i tlenku dibutylocyny (DBTO) rozpuszczonych w bezwodnym 2-propanolu z chlorkiem kwasu anyżowego w obecności trietyloaminy (TEA). Związek ten wykazuje aktywność antyproliferacyjną względem komórek nowotworowych białaczki i może znaleźć zastosowanie w przemyśle kosmetycznym i farmaceutycznym.The invention relates to a phospholipid aniseic acid derivative of the formula I and a method for its preparation by reaction of sn-glycerol-3-phosphocholine (GPC) and dibutyltin oxide (DBTO) dissolved in anhydrous 2-propanol with anisic acid chloride in the presence of triethylamine (TEA). This compound has antiproliferative activity against leukemia cancer cells and may find use in the cosmetics and pharmaceutical industries.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415744A PL227313B1 (en) | 2016-01-11 | 2016-01-11 | 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415744A PL227313B1 (en) | 2016-01-11 | 2016-01-11 | 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL415744A1 true PL415744A1 (en) | 2016-08-01 |
| PL227313B1 PL227313B1 (en) | 2017-11-30 |
Family
ID=56511186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415744A PL227313B1 (en) | 2016-01-11 | 2016-01-11 | 1-Anisoyl-2-hydroxy-sn-glycero-3-phosphocholine and method for obtaining it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL227313B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL422073A1 (en) * | 2017-06-30 | 2019-01-02 | Uniwersytet Przyrodniczy we Wrocławiu | Phosphatidylcholines and method for obtaining them |
| PL422072A1 (en) * | 2017-06-30 | 2019-01-02 | Uniwersytet Przyrodniczy we Wrocławiu | Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 |
-
2016
- 2016-01-11 PL PL415744A patent/PL227313B1/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL422073A1 (en) * | 2017-06-30 | 2019-01-02 | Uniwersytet Przyrodniczy we Wrocławiu | Phosphatidylcholines and method for obtaining them |
| PL422072A1 (en) * | 2017-06-30 | 2019-01-02 | Uniwersytet Przyrodniczy we Wrocławiu | Method for obtaining phosphatidylcholine containing ibuprofen in position sn-1 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL227313B1 (en) | 2017-11-30 |
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