PL415643A1 - Concentration of iron in blood and changes within GPX1 gene as risk factors for cancers in women - Google Patents
Concentration of iron in blood and changes within GPX1 gene as risk factors for cancers in womenInfo
- Publication number
- PL415643A1 PL415643A1 PL415643A PL41564315A PL415643A1 PL 415643 A1 PL415643 A1 PL 415643A1 PL 415643 A PL415643 A PL 415643A PL 41564315 A PL41564315 A PL 41564315A PL 415643 A1 PL415643 A1 PL 415643A1
- Authority
- PL
- Poland
- Prior art keywords
- concentration
- gpx1
- iron
- serum
- women
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 12
- 229910052742 iron Inorganic materials 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 101150115464 GPX1 gene Proteins 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000002966 serum Anatomy 0.000 abstract 5
- 201000011510 cancer Diseases 0.000 abstract 3
- 102100033039 Glutathione peroxidase 1 Human genes 0.000 abstract 2
- 101001014936 Homo sapiens Glutathione peroxidase 1 Proteins 0.000 abstract 2
- 239000012620 biological material Substances 0.000 abstract 2
- 102200155575 rs1050450 Human genes 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
W zgłoszeniu stwierdzono, że występuje korelacja między genotypem genu GPX1 (rs1050450), poziomem żelaza w surowicy a ryzykiem raków u kobiet w Polsce. Przedmiotem zgłoszenia jest sposób określania ryzyka raka. Sposób charakteryzuje się tym, że obejmuje ocenę konstytucyjnej zmiany w genie GPX1 Pro200Leu (rs 1050450) oraz ocenę stężenia żelaza w próbce biologicznej badanej kobiety, przy czym kombinacja poszczególnych genotypów z określonym stężeniem żelaza wskazuje znacząco obniżone ryzyko rozwoju raków: - dla genotypu GPX1 CC przy stężeniu żelaza w surowicy 1050-1350 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy); - dla genotypu GPX1 nCC przy stężeniu żelaza w surowicy 725-900 µg/l (lub stężeniu w dowolnym materiale biologicznym odpowiadającym stężeniu w surowicy).The application states that there is a correlation between the GPX1 gene genotype (rs1050450), serum iron levels and the risk of cancer in women in Poland. The subject of the notification is how to determine cancer risk. The method is characterized in that it includes the assessment of the constitutional change in the GPX1 Pro200Leu gene (rs 1050450) and the assessment of the iron concentration in the biological sample of the examined woman, where the combination of individual genotypes with a specific iron concentration indicates a significantly reduced risk of cancer development: - for the GPX1 CC genotype a serum iron concentration of 1050-1350 µg / l (or a concentration in any biological material corresponding to a serum concentration); - for the GPX1 nCC genotype at a serum iron concentration of 725-900 µg / l (or the concentration in any biological material corresponding to the serum concentration).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415643A PL415643A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within GPX1 gene as risk factors for cancers in women |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL415643A PL415643A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within GPX1 gene as risk factors for cancers in women |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL415643A1 true PL415643A1 (en) | 2017-07-03 |
Family
ID=59201401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL415643A PL415643A1 (en) | 2015-12-30 | 2015-12-30 | Concentration of iron in blood and changes within GPX1 gene as risk factors for cancers in women |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL415643A1 (en) |
-
2015
- 2015-12-30 PL PL415643A patent/PL415643A1/en unknown
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