PL40968B1 - - Google Patents
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- Publication number
- PL40968B1 PL40968B1 PL40968A PL4096857A PL40968B1 PL 40968 B1 PL40968 B1 PL 40968B1 PL 40968 A PL40968 A PL 40968A PL 4096857 A PL4096857 A PL 4096857A PL 40968 B1 PL40968 B1 PL 40968B1
- Authority
- PL
- Poland
- Prior art keywords
- water
- vitamins
- carried out
- vitamin
- solutions
- Prior art date
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- 229930003231 vitamin Natural products 0.000 claims description 13
- 229940088594 vitamin Drugs 0.000 claims description 13
- 235000013343 vitamin Nutrition 0.000 claims description 13
- 239000011782 vitamin Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 9
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000005642 Oleic acid Substances 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- -1 polyoxyethylene Polymers 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 2
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 229960002061 ergocalciferol Drugs 0.000 claims description 2
- 239000011261 inert gas Substances 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 235000001892 vitamin D2 Nutrition 0.000 claims description 2
- 239000011653 vitamin D2 Substances 0.000 claims description 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 2
- 239000003921 oil Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Description
Opublikowano dnia 1 kwietnia 1&9S r.BIS L-IOTEKAj ||/X Urzedu Patentowego WrtiiltattHWwIitefLi' POLSKIEJ RZECZYPOSPOLITEJ LUDOWEJ OPIS PATENTOWY Nr 40968 Eugeniusz Janiszewski Warszawa, Polska KI. 30 h, 2/20 ¦^ Sposób wytwarzania trwalych wodnych roztworów koloidalnych witamin nierozpuszczalnych w wodzie, zwlaszcza CalcileroliPkryslalicznego Patent trwa od dnia 30 lipca 1957 r.Sporzadzanie olejowych roztworów witamin nierozpuszczalnych w wodzie, zwlaszcza krysta¬ licznej witaminy D2 (Calciferolu) stosowanych do zastrzyków, natrafia na wiele trudnosci.Czesto zdarza sie, ze witaminy wytracaja sie z roztworu olejowego, w zwiazku z czym traca swoje dzialanie terapeutyczne, i musza byc wycofane z obiegu. Wyplywa to stad, ze olej nie zawsze jest odpowiednio oczyszczony, ze wzgledu na trudnosci techniczne zwiazane z jego bardzo dokladna rafinacja, ponadto moze za¬ wierac on minimalne ilosci substancji szkodli¬ wych, których dokladne oznaczenie jest bardzo uciazliwe. Róznorodnosc gatunków olejów tego samego pochodzenia takze stwarza dodatkowe trudnosci przy stosowaniu ich jako rozpuszczal¬ ników dla witamin. Roztwory spirytusowe wi¬ tamin nie znalazly szerszego zastosowania.Te powazne niedogodnosci usuwa sposób we¬ dlug wynalazku polegajacy na tym, ze wita¬ mine nierozpuszczalna w wodzie rozpuszcza sie w minimalnej ilosci jakiegokolwiek rozpuszczal¬ nika posiadajacego grupe polarna, a nie naru¬ szajacego struktury chemicznej witaminy. Roz¬ twór ten wedlug wynalazku stabilizuje sie roz¬ tworem dekstranu lub polioksyetylenu estry¬ fikowanego kwasem oleinowym, po czym roz¬ ciencza sie go woda destylowana (pro injectio) do pozadanej koncentracji.Sposobem wedlug wynalazku, mozna równiez witamine rozpuscic bezposrednio w polioksy- etylenie estryfikowanym kwasem oleinowym, który dziala jednoczesnie jako stabilizator. Roz¬ puszczenie nalezy przy tym przeprowadzic w temperaturze nizszej od temperatury rozkla¬ du danej witaminy. Calciferol i reszte witamin D mozna ogrzac do temperatury 130°C. Otrzy¬ many roztwór rozprasza sie do pozadanej kon¬ centracji w wodzie swiezej i pozbawionej po¬ wietrza.Rozpraszanie roztworów witamin w wodzie w sposób szybki przeprowadza sie w homogeni-zatorze pod cisnieniem do 250 atmosfer. Wpraw¬ ny chemik wykona ten zabieg w skali laborato¬ ryjnej w i^yWym mieszadelku. f^ :t Stwierdzono, \e najtfcrdziej trwale roztwory ^ koloidalne witamin w wótfzie, zwlaszcza Calci- fesolu i Akseroftolu, uzyskuje sie wtedy, jezeli , wspomniane zabiegi przeprowadza sie w atmo¬ sferze gazu obojetnego, na przyklad azotu. — PLPublished on 1 April 1 & 9S r.BIS L-IOTEKAj || / X Urzedu Patentowego WrtiiltattHWwIitefLi 'POLSKIE RZECZYPOLITEJ PEOPLEJ PATENT DESCRIPTION No. 40968 Eugeniusz Janiszewski Warsaw, Poland KI. 30 h, 2/20 ¦ ^ Method for the production of stable aqueous colloidal solutions of water-insoluble vitamins, especially Calcilerol, Crispalline The patent is valid from July 30, 1957. , encounters many difficulties. It often happens that vitamins are lost from the oily solution, and therefore lose their therapeutic effect, and must be withdrawn from circulation. This results in the fact that the oil is not always properly purified, due to technical difficulties related to its very precise refining, moreover, it may contain minimal amounts of harmful substances, the precise determination of which is very onerous. The variety of oils of the same origin also creates additional difficulties when using them as solvents for vitamins. Vitamin spirit solutions have found little use. These serious disadvantages are overcome by the process of the invention whereby the water-insoluble vitamin is dissolved in a minimal amount of any solvent having a polar group and not disturbing the chemical structure. vitamins. According to the invention, this solution is stabilized with a solution of dextran or polyoxyethylene esterified with oleic acid and then diluted with distilled water (pro injectio) to the desired concentration. According to the invention, it is also possible to dissolve the vitamin directly in polyoxyethylene. with esterified oleic acid which also acts as a stabilizer. The dissolution must be carried out at a temperature below the decomposition temperature of the vitamin in question. Calciferol and the rest of the Vitamin D can be heated to 130 ° C. The resulting solution is dispersed to the desired concentration in fresh and airless water. The dispersion of the vitamin solutions in the water is rapidly carried out in a homogenizer under a pressure of up to 250 atmospheres. A skilled chemist will perform this procedure on a laboratory scale in a living agitator. It has been found that the most stable colloidal solutions of vitamins in water, especially Calcifesol and Akserophtol, are obtained when the said treatments are carried out in an atmosphere of an inert gas, for example nitrogen. - PL
Claims (3)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL40968B1 true PL40968B1 (en) | 1958-02-15 |
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