GB1016079A - Oxazaphospholidines - Google Patents
OxazaphospholidinesInfo
- Publication number
- GB1016079A GB1016079A GB539465A GB539465A GB1016079A GB 1016079 A GB1016079 A GB 1016079A GB 539465 A GB539465 A GB 539465A GB 539465 A GB539465 A GB 539465A GB 1016079 A GB1016079 A GB 1016079A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ephedrine
- oxazaphospholidines
- ccl4
- intermediates
- triethylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UQZZQHGRZPTZME-UHFFFAOYSA-N oxazaphospholidine Chemical class C1CPNO1 UQZZQHGRZPTZME-UHFFFAOYSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229960002179 ephedrine Drugs 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000007530 organic bases Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises L-, D-, and DL-2-chloro - 3,4 - dimethyl - 5 - phenyl - 2 - oxide - 1,3,2 - oxazaphospholidines. They may be obtained by treating the corresponding L-, D-, or DL-ephedrine dissolved in an inert solvent, e.g. benzene, ether or CCL4, with phosphorus oxychloride in the presence of a basic material, e.g. a tertiary organic base such as triethylamine. The products are useful as intermediates for the preparation of ephedrine phosphoric ester derivatives as disclosed in Specification 1,016,078 is referred to.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1963861 | 1961-10-26 | ||
IT1587962 | 1962-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1016079A true GB1016079A (en) | 1966-01-05 |
Family
ID=26326820
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB539465A Expired GB1016079A (en) | 1961-10-26 | 1962-10-25 | Oxazaphospholidines |
GB4042062A Expired GB1016078A (en) | 1961-10-26 | 1962-10-25 | Phosphorus-containing ephedrine derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4042062A Expired GB1016078A (en) | 1961-10-26 | 1962-10-25 | Phosphorus-containing ephedrine derivatives |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB1016079A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8401534D0 (en) * | 1984-01-20 | 1984-02-22 | Royal Free Hosp School Med | Biocompatible surfaces |
US5380904A (en) * | 1984-01-20 | 1995-01-10 | Biocompatibles Ltd. | Process for rendering a surface biocompatible, and articles containing the same |
US5229162A (en) * | 1984-01-20 | 1993-07-20 | Biocompatibles Ltd. | Article having biocompatible surface |
-
1962
- 1962-10-25 GB GB539465A patent/GB1016079A/en not_active Expired
- 1962-10-25 GB GB4042062A patent/GB1016078A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1016078A (en) | 1966-01-05 |
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