PL4043490T3 - Fragment humanizowanego przeciwciała fab anty-vegf i jego zastosowanie - Google Patents

Fragment humanizowanego przeciwciała fab anty-vegf i jego zastosowanie

Info

Publication number
PL4043490T3
PL4043490T3 PL20844600.5T PL20844600T PL4043490T3 PL 4043490 T3 PL4043490 T3 PL 4043490T3 PL 20844600 T PL20844600 T PL 20844600T PL 4043490 T3 PL4043490 T3 PL 4043490T3
Authority
PL
Poland
Prior art keywords
antibody fragment
humanized anti
fab antibody
vegf fab
vegf
Prior art date
Application number
PL20844600.5T
Other languages
English (en)
Inventor
Liangzhi Xie
Chunyun SUN
Jun Zhao
Desheng KONG
Original Assignee
Sinocelltech Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinocelltech Ltd. filed Critical Sinocelltech Ltd.
Publication of PL4043490T3 publication Critical patent/PL4043490T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL20844600.5T 2019-07-19 2020-07-17 Fragment humanizowanego przeciwciała fab anty-vegf i jego zastosowanie PL4043490T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910657311 2019-07-19
PCT/CN2020/102560 WO2021013065A1 (zh) 2019-07-19 2020-07-17 人源化抗VEGF Fab抗体片段及其用途

Publications (1)

Publication Number Publication Date
PL4043490T3 true PL4043490T3 (pl) 2026-03-09

Family

ID=74192837

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20844600.5T PL4043490T3 (pl) 2019-07-19 2020-07-17 Fragment humanizowanego przeciwciała fab anty-vegf i jego zastosowanie

Country Status (15)

Country Link
US (1) US12479911B2 (pl)
EP (1) EP4043490B1 (pl)
JP (1) JP7229419B2 (pl)
KR (1) KR102920224B1 (pl)
CN (1) CN114127106B (pl)
AU (1) AU2020316495B2 (pl)
BR (1) BR112022001021A2 (pl)
CA (1) CA3150046C (pl)
ES (1) ES3050609T3 (pl)
HR (1) HRP20251352T1 (pl)
MX (1) MX2022000780A (pl)
MY (1) MY203236A (pl)
PL (1) PL4043490T3 (pl)
RS (1) RS67370B1 (pl)
WO (1) WO2021013065A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102920217B1 (ko) * 2019-07-19 2026-01-30 사이노셀테크 엘티디. 인간화 항-vegf 단클론 항체
WO2024055995A1 (zh) * 2022-09-14 2024-03-21 寻济生物科技（北京）有限公司 一种抗vegfa融合蛋白及其制备方法和应用
WO2024055996A1 (zh) * 2022-09-14 2024-03-21 寻济生物科技（北京）有限公司 一种抗vegfa抗体或其抗原结合片段及其应用
WO2025117716A1 (en) * 2023-11-30 2025-06-05 Watchmaker Genomics, Inc. Taq dna polymerase hotstart antibodies and methods of use thereof
WO2025147472A1 (en) * 2024-01-02 2025-07-10 Phanes Therapeutics, Inc. Anti-611-ctf p95her2 antibodies and uses thereof
CN120025456B (zh) * 2024-03-13 2025-11-07 寻济生物科技（北京）有限公司 一种抗vegfa融合构建体及其制备方法和应用
US20260042864A1 (en) * 2024-08-09 2026-02-12 Watchmaker Genomics, Inc. Hot-start antibodies for taq dna polymerase variant
WO2026080438A1 (en) * 2024-10-07 2026-04-16 Intuitive Biosciences, Inc. Compositions and methods for detection treatment, and prevention of hiv infection

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
CA2323757C (en) 1998-04-02 2011-08-02 Genentech, Inc. Antibody variants and fragments thereof
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7667004B2 (en) 2001-04-17 2010-02-23 Abmaxis, Inc. Humanized antibodies against vascular endothelial growth factor
US20050106667A1 (en) * 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US9434716B2 (en) * 2011-03-01 2016-09-06 Glaxo Group Limited Antigen binding proteins
CN102286101B (zh) * 2011-08-08 2013-05-08 常州亚当生物技术有限公司 抗VEGF单克隆抗体Fab片段Vasculizumab及其应用
US9388239B2 (en) * 2014-05-01 2016-07-12 Consejo Nacional De Investigation Cientifica Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
JP6959912B2 (ja) * 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
EP3401331B1 (en) * 2016-01-06 2022-04-06 Order-Made Medical Research Inc. High-affinity anti-vegf antibody
US11254738B2 (en) * 2016-09-07 2022-02-22 The Governing Council Of The University Of Toronto Banting Institute Synthetic antibodies against VEGF and their uses
KR102920217B1 (ko) * 2019-07-19 2026-01-30 사이노셀테크 엘티디. 인간화 항-vegf 단클론 항체

Also Published As

Publication number Publication date
CN114127106A (zh) 2022-03-01
KR20220034868A (ko) 2022-03-18
AU2020316495A1 (en) 2022-02-03
ES3050609T3 (en) 2025-12-22
MY203236A (en) 2024-06-19
EP4043490A4 (en) 2023-08-16
BR112022001021A2 (pt) 2022-04-12
KR102920224B1 (ko) 2026-01-30
WO2021013065A1 (zh) 2021-01-28
EP4043490A1 (en) 2022-08-17
US12479911B2 (en) 2025-11-25
MX2022000780A (es) 2022-02-14
CA3150046A1 (en) 2021-01-28
CA3150046C (en) 2023-11-14
EP4043490B1 (en) 2025-08-27
RS67370B1 (sr) 2025-11-28
CN114127106B (zh) 2024-01-12
JP7229419B2 (ja) 2023-02-27
JP2022537072A (ja) 2022-08-23
HRP20251352T1 (hr) 2025-12-19
EP4043490C0 (en) 2025-08-27
US20220135665A1 (en) 2022-05-05
AU2020316495B2 (en) 2024-07-04

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