PL398211A1 - RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process - Google Patents

RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process

Info

Publication number
PL398211A1
PL398211A1 PL398211A PL39821112A PL398211A1 PL 398211 A1 PL398211 A1 PL 398211A1 PL 398211 A PL398211 A PL 398211A PL 39821112 A PL39821112 A PL 39821112A PL 398211 A1 PL398211 A1 PL 398211A1
Authority
PL
Poland
Prior art keywords
mirna
rna
regulators
oligomers
regulating
Prior art date
Application number
PL398211A
Other languages
Polish (pl)
Inventor
Anna Kurzynska-Kokorniak
Marek Figlerowicz
Natalia Koralewska
Agata Tyczewska
Tomasz Twardowski
Original Assignee
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instytut Chemii Bioorganicznej Polskiej Akademii Nauk filed Critical Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
Priority to PL398211A priority Critical patent/PL398211A1/en
Priority to PCT/PL2013/000024 priority patent/WO2013125967A1/en
Priority to EP13711481.5A priority patent/EP2817408A1/en
Publication of PL398211A1 publication Critical patent/PL398211A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Przedmiotem wynalazku sa -oligomer RNA, sposób regulowania procesu powstawania miRNA oraz zastosowanie oligomerów RNA, jako regulatorów procesu powstawania miRNA. Bardziej szczególowo, rozwiazanie dotyczy zastosowania oligomerów RNA zaburzajacych strukture pre-miRNA, jako regulatorów procesu powstawania miRNA. Oddzialywania oligomeru z prekursorem miRNA (pre-miRNA) zmieniaja strukture drugo- i trzeciorzedowa prekursora. W rezultacie, pre-miRNA nie jest specyficznie rozpoznawany i ciety przez rybonukleaze Dicer i w konsekwencji nie dochodzi do powstawania okreslonego miRNA.The subject of the invention is RNA oligomer, a method of regulating miRNA formation and the use of RNA oligomers as regulators of miRNA formation. More specifically, the solution relates to the use of RNA oligomers disrupting the pre-miRNA structure as regulators of the miRNA formation process. Interactions of the oligomer with the miRNA precursor (pre-miRNA) change the precursor secondary and tertiary structure. As a result, pre-miRNA is not specifically recognized and cleaved by Dicer ribonuclease, and consequently no specific miRNA is produced.

PL398211A 2012-02-22 2012-02-22 RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process PL398211A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL398211A PL398211A1 (en) 2012-02-22 2012-02-22 RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process
PCT/PL2013/000024 WO2013125967A1 (en) 2012-02-22 2013-02-20 An rna oligomer, methods for regulating a microrna production process and rna oligomers used as microrna production process regulators
EP13711481.5A EP2817408A1 (en) 2012-02-22 2013-02-20 An rna oligomer, methods for regulating a microrna production process and rna oligomers used as microrna production process regulators

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL398211A PL398211A1 (en) 2012-02-22 2012-02-22 RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process

Publications (1)

Publication Number Publication Date
PL398211A1 true PL398211A1 (en) 2013-09-02

Family

ID=47915310

Family Applications (1)

Application Number Title Priority Date Filing Date
PL398211A PL398211A1 (en) 2012-02-22 2012-02-22 RNA oligomer, method for regulating the process of creation the miRNA and the use of RNA re oligomers as regulators of the miRNA formation process

Country Status (3)

Country Link
EP (1) EP2817408A1 (en)
PL (1) PL398211A1 (en)
WO (1) WO2013125967A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018047148A1 (en) * 2016-09-12 2018-03-15 Novartis Ag Compounds for the inhibition of mirna

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683036B2 (en) * 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
PL212696B1 (en) * 2008-02-14 2012-11-30 Inst Chemii Bioorg Pan The manner of inhibiting of Dicer ribonuclease, Dicer ribonuclease inhibotor and application of RNA aptamers as Dicer ribonuclease inhibitors
US20110172295A1 (en) * 2008-04-11 2011-07-14 The University Of North Carolina At Chapel Hill METHODS AND COMPOSITIONS FOR THE REGULATION OF microRNA PROCESSING

Also Published As

Publication number Publication date
EP2817408A1 (en) 2014-12-31
WO2013125967A1 (en) 2013-08-29

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