PL37817B1 - - Google Patents
Download PDFInfo
- Publication number
- PL37817B1 PL37817B1 PL37817A PL3781754A PL37817B1 PL 37817 B1 PL37817 B1 PL 37817B1 PL 37817 A PL37817 A PL 37817A PL 3781754 A PL3781754 A PL 3781754A PL 37817 B1 PL37817 B1 PL 37817B1
- Authority
- PL
- Poland
- Prior art keywords
- fractions
- isonicotinic acid
- separated
- lutidine
- components
- Prior art date
Links
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 11
- BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 claims description 6
- JYYNAJVZFGKDEQ-UHFFFAOYSA-N 2,4-Dimethylpyridine Chemical group CC1=CC=NC(C)=C1 JYYNAJVZFGKDEQ-UHFFFAOYSA-N 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 5
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 claims description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 4
- AUHZEENZYGFFBQ-UHFFFAOYSA-N 1,3,5-Me3C6H3 Natural products CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 2
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 5
- 238000006114 decarboxylation reaction Methods 0.000 description 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical class CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 3
- ITQTTZVARXURQS-UHFFFAOYSA-N 3-methylpyridine Chemical compound CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 description 2
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N 4-methylpyridine Chemical compound CC1=CC=NC=C1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 2
- HOPRXXXSABQWAV-UHFFFAOYSA-N anhydrous collidine Natural products CC1=CC=NC(C)=C1C HOPRXXXSABQWAV-UHFFFAOYSA-N 0.000 description 2
- UTBIMNXEDGNJFE-UHFFFAOYSA-N collidine Natural products CC1=CC=C(C)C(C)=N1 UTBIMNXEDGNJFE-UHFFFAOYSA-N 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000000911 decarboxylating effect Effects 0.000 description 1
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960005375 lutein Drugs 0.000 description 1
- 239000001656 lutein Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL37817B1 true PL37817B1 (cg-RX-API-DMAC7.html) | 1954-10-15 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5861419A (en) | Substituted pyridines as selective cyclooxygenase-2 inhibitors | |
| EP0673931B1 (de) | Sulfonamidocarbonylpyridin-2-carbonsäureamide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
| Finger et al. | Aromatic Fluorine Compounds. IX. 2-Fluoropyridines1, 2 | |
| JP2013535448A (ja) | ＧＰＲ３５および／またはＧＰＲ３５−ｈＥＲＧ複合体に関連する病的状態の治療のための組成物および方法 | |
| Den Hertog et al. | The directive influence of the N‐oxide group during the nitration of derivatives of pyridine‐N‐oxide | |
| Katritzky | 464. The preparation of some substituted pyridine 1-oxides | |
| PL37817B1 (cg-RX-API-DMAC7.html) | ||
| Mailey et al. | Fluoroalkylpyridines. A novel rearrangement | |
| Hamer et al. | Preparation of 2‐fluoroquinoline and 2, 6‐difluoropyridine by halogen exchange | |
| DE1620166A1 (de) | Verfahren zur Herstellung von Carbamaten und Thiocarbamaten | |
| CN106674098A (zh) | N‑(3‑氰基‑4‑烷氧基苯基)吡啶甲酰胺类化合物及其用途 | |
| US2516370A (en) | Beta-picolines | |
| AU662448B2 (en) | Acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments | |
| US3668209A (en) | Separation of chlorinated pyridines and derivatives thereof | |
| US2721202A (en) | Process for the manufacture of pure | |
| PL50079B1 (cg-RX-API-DMAC7.html) | ||
| Adamczyk et al. | Transformation of Vitamin B6 to (+)-Deoxypyridinoline, a useful Biochemical Marker for Diagnosis of Bone Diseases | |
| IT1124789B (it) | Derivati anilidici dell'acido cianacetico,processo per la loro preparazione e mezzi che contengono tali composti | |
| US3432510A (en) | Pyridinecarboxylic acid esters of pyridinedimethanols | |
| US2775591A (en) | Alcohol-amine complexes | |
| DE2446119A1 (de) | 2-substituierte 1,2,4-thadiazoloeckige klammer auf 2,3-a eckige klammer zu -benzimidazole und verfahren zu ihrer herstellung | |
| EP0567997A1 (de) | 4- oder 5-(Sulf)imido- und (Sulfon)amidopyridine, sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
| DE977578C (de) | Verfahren zur Herstellung von 3- oder 4-Cyan-pyridin | |
| PL36405B1 (cg-RX-API-DMAC7.html) | ||
| Lidstone | 48. The separation of β-picoline, γ-picoline, and 2: 6-lutidine from their mixture |