PL3778609T3 - Pochodne penamu lub ich sole, kompozycje farmaceutyczne i ich zastosowanie - Google Patents

Pochodne penamu lub ich sole, kompozycje farmaceutyczne i ich zastosowanie

Info

Publication number
PL3778609T3
PL3778609T3 PL19781624T PL19781624T PL3778609T3 PL 3778609 T3 PL3778609 T3 PL 3778609T3 PL 19781624 T PL19781624 T PL 19781624T PL 19781624 T PL19781624 T PL 19781624T PL 3778609 T3 PL3778609 T3 PL 3778609T3
Authority
PL
Poland
Prior art keywords
salts
pharmaceutical compositions
penam derivatives
penam
derivatives
Prior art date
Application number
PL19781624T
Other languages
English (en)
Inventor
Muneo Shoji
Kentaro Furuya
Kei Matsuura
Tomofumi Nakae
Original Assignee
Fujifilm Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corporation filed Critical Fujifilm Corporation
Publication of PL3778609T3 publication Critical patent/PL3778609T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/70Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/76Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with hetero rings directly attached to the carboxamido radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/897Compounds with substituents other than a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL19781624T 2018-04-06 2019-04-05 Pochodne penamu lub ich sole, kompozycje farmaceutyczne i ich zastosowanie PL3778609T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018073568 2018-04-06
EP19781624.2A EP3778609B1 (en) 2018-04-06 2019-04-05 Penam derivatives or salts thereof, pharmaceutical compositions and use thereof
PCT/JP2019/015176 WO2019194306A1 (ja) 2018-04-06 2019-04-05 新規なペナム誘導体又はその塩、医薬組成物及びその応用

Publications (1)

Publication Number Publication Date
PL3778609T3 true PL3778609T3 (pl) 2022-04-25

Family

ID=68100759

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19781624T PL3778609T3 (pl) 2018-04-06 2019-04-05 Pochodne penamu lub ich sole, kompozycje farmaceutyczne i ich zastosowanie

Country Status (19)

Country Link
US (1) US12286440B2 (pl)
EP (1) EP3778609B1 (pl)
JP (1) JP7092869B2 (pl)
KR (1) KR102442994B1 (pl)
CN (1) CN111954673B (pl)
AU (1) AU2019249008B2 (pl)
CA (1) CA3096177C (pl)
CY (1) CY1125078T1 (pl)
DK (1) DK3778609T3 (pl)
ES (1) ES2908044T3 (pl)
HR (1) HRP20220408T1 (pl)
LT (1) LT3778609T (pl)
PL (1) PL3778609T3 (pl)
PT (1) PT3778609T (pl)
RS (1) RS63060B1 (pl)
SI (1) SI3778609T1 (pl)
SM (1) SMT202200150T1 (pl)
TW (1) TWI795549B (pl)
WO (1) WO2019194306A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114531850B (zh) * 2019-10-04 2024-08-06 富士胶片株式会社 以含有新的青霉素衍生物或其盐以及选自β-内酰胺酶抑制化合物及抗菌性化合物或其盐中的1种以上的化合物为特征的医药组合物及试剂盒
KR102657446B1 (ko) * 2021-09-27 2024-04-17 서울대학교산학협력단 항균용 조성물
KR20250071123A (ko) 2023-11-14 2025-05-21 신재환 폴더블 휴대폰 흰지 완전 보호 케이스

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH089627B2 (ja) * 1986-12-23 1996-01-31 富山化学工業株式会社 新規なペナム誘導体またはその塩
CA2019260C (en) * 1989-06-22 1999-06-29 Hirokazu Ochiai Penam derivatives and salts thereof, processes for producing the same and antibacterial agent comprising the same
JP2973126B2 (ja) 1989-06-22 1999-11-08 富山化学工業株式会社 新規なペナム誘導体およびその塩
JP3523664B2 (ja) * 1992-05-18 2004-04-26 富山化学工業株式会社 新規なペナム誘導体またはその塩
JPH10130272A (ja) * 1996-10-25 1998-05-19 Toyama Chem Co Ltd 2−カルボキシペナム誘導体またはその塩の製造法
JP2936404B2 (ja) 1998-01-16 1999-08-23 富山化学工業株式会社 ペナム−3−カルボン酸誘導体の製造法およびペナム−2,3−ジカルボン酸誘導体
TWI547496B (zh) * 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
KR20180066264A (ko) * 2015-12-10 2018-06-18 나에자-알지엠 파마슈티칼스 유엘씨 세펨 화합물, 그의 제조 및 용도

Also Published As

Publication number Publication date
US12286440B2 (en) 2025-04-29
EP3778609B1 (en) 2022-01-26
AU2019249008A1 (en) 2020-10-22
DK3778609T3 (da) 2022-03-14
KR20200128556A (ko) 2020-11-13
LT3778609T (lt) 2022-04-25
US20210024543A1 (en) 2021-01-28
AU2019249008B2 (en) 2021-11-11
CN111954673B (zh) 2023-09-05
KR102442994B1 (ko) 2022-09-13
SMT202200150T1 (it) 2022-05-12
TWI795549B (zh) 2023-03-11
JP7092869B2 (ja) 2022-06-28
CN111954673A (zh) 2020-11-17
JPWO2019194306A1 (ja) 2021-03-11
RS63060B1 (sr) 2022-04-29
HRP20220408T1 (hr) 2022-05-27
CA3096177A1 (en) 2019-10-10
ES2908044T3 (es) 2022-04-27
CY1125078T1 (el) 2024-02-16
PT3778609T (pt) 2022-03-02
CA3096177C (en) 2023-12-12
TW202005969A (zh) 2020-02-01
SI3778609T1 (sl) 2022-06-30
WO2019194306A1 (ja) 2019-10-10
EP3778609A4 (en) 2021-02-17
EP3778609A1 (en) 2021-02-17

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