PL359260A1 - Bicykliczne cykloheksyloaminy i ich zastosowanie jako antagonistów receptora NMDA - Google Patents
Bicykliczne cykloheksyloaminy i ich zastosowanie jako antagonistów receptora NMDAInfo
- Publication number
- PL359260A1 PL359260A1 PL01359260A PL35926001A PL359260A1 PL 359260 A1 PL359260 A1 PL 359260A1 PL 01359260 A PL01359260 A PL 01359260A PL 35926001 A PL35926001 A PL 35926001A PL 359260 A1 PL359260 A1 PL 359260A1
- Authority
- PL
- Poland
- Prior art keywords
- biciclic
- cyclohexylamines
- nmda receptor
- receptor antogonists
- antogonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20824100P | 2000-05-31 | 2000-05-31 | |
PCT/US2001/014763 WO2001092239A1 (en) | 2000-05-31 | 2001-05-08 | Biciclic cyclohexylamines and their use as nmda receptor antogonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PL359260A1 true PL359260A1 (pl) | 2004-08-23 |
Family
ID=22773822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL01359260A PL359260A1 (pl) | 2000-05-31 | 2001-05-08 | Bicykliczne cykloheksyloaminy i ich zastosowanie jako antagonistów receptora NMDA |
Country Status (28)
Country | Link |
---|---|
US (1) | US6794402B2 (pl) |
EP (1) | EP1286975B1 (pl) |
JP (1) | JP2003535083A (pl) |
KR (1) | KR20030007797A (pl) |
CN (1) | CN1438996A (pl) |
AP (1) | AP2002002697A0 (pl) |
AT (1) | ATE302763T1 (pl) |
AU (1) | AU2001259618A1 (pl) |
BG (1) | BG107375A (pl) |
BR (1) | BR0111301A (pl) |
CA (1) | CA2409006A1 (pl) |
DE (1) | DE60112924T2 (pl) |
DZ (1) | DZ3361A1 (pl) |
EA (1) | EA200201158A1 (pl) |
EE (1) | EE200200667A (pl) |
ES (1) | ES2245985T3 (pl) |
HR (1) | HRP20021018A2 (pl) |
HU (1) | HUP0302323A2 (pl) |
IL (1) | IL153170A0 (pl) |
IS (1) | IS6625A (pl) |
MA (1) | MA26907A1 (pl) |
MX (1) | MXPA02011926A (pl) |
NO (1) | NO20025762L (pl) |
OA (1) | OA12275A (pl) |
PL (1) | PL359260A1 (pl) |
SK (1) | SK16632002A3 (pl) |
WO (1) | WO2001092239A1 (pl) |
ZA (1) | ZA200209325B (pl) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA02002749A (es) * | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
GB0116594D0 (en) * | 2001-07-06 | 2001-08-29 | Cancer Res Ventures Ltd | Therapeutic compounds |
DE10210779A1 (de) * | 2002-03-12 | 2003-10-09 | Merck Patent Gmbh | Cyclische Amide |
EP2319838A1 (en) | 2002-06-07 | 2011-05-11 | Cortical Pty Ltd | Therapeutic Molecules and Methods-1 |
US7307099B2 (en) | 2002-12-20 | 2007-12-11 | Cancer Research Technology Limited | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents |
JP2008525439A (ja) * | 2004-12-23 | 2008-07-17 | ボイジャー・ファーマシューティカル・コーポレーション | アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはnmdaレセプターアゴニスト |
JP5270943B2 (ja) * | 2008-03-28 | 2013-08-21 | 大阪瓦斯株式会社 | フルオレン誘導体およびこのフルオレン誘導体を用いたアミノ基含有フルオレン誘導体の製造方法 |
US9345848B2 (en) | 2009-10-20 | 2016-05-24 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. | Dry powder inhaler |
WO2011092293A2 (en) * | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
JP6037396B2 (ja) | 2012-01-27 | 2016-12-07 | 国立大学法人富山大学 | セリンラセマーゼ阻害剤 |
CN105061254A (zh) * | 2015-07-20 | 2015-11-18 | 湖南华腾制药有限公司 | 一种含溴叠氮化合物的合成方法 |
CN105152966A (zh) * | 2015-07-20 | 2015-12-16 | 湖南华腾制药有限公司 | 一种叠氮化合物的制备方法 |
CN105153020A (zh) * | 2015-07-20 | 2015-12-16 | 湖南华腾制药有限公司 | 一种芳香叠氮化合物的制备方法 |
CN105001118A (zh) * | 2015-07-20 | 2015-10-28 | 湖南华腾制药有限公司 | 一种含碘叠氮化合物的制备方法 |
WO2018033525A1 (en) * | 2016-08-16 | 2018-02-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Agonists or partial agonists of the histamine site of the nmda receptor for use in the treatment of central nervous system diseases |
CN107043335A (zh) * | 2017-05-31 | 2017-08-15 | 湖南华腾制药有限公司 | 一种2‑氟苯基叠氮化合物的制备方法 |
WO2019043217A1 (en) * | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4438055A1 (de) * | 1994-10-25 | 1996-05-02 | Thomae Gmbh Dr K | Ring- und N-substituierte N-Benzyl-cycloalkylamine, ihre Salze mit physiologisch verträglichen organischen oder anorganischen Säuren, Verfahren zur Herstellung dieser Verbindungen und diese enthaltende Arzneimittel |
DE19812331A1 (de) * | 1998-03-20 | 1999-09-23 | Merck Patent Gmbh | Piperidinderivate |
EP0982026B1 (en) | 1998-08-18 | 2006-05-17 | F. Hoffmann-La Roche Ag | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers |
-
2001
- 2001-05-08 EA EA200201158A patent/EA200201158A1/ru unknown
- 2001-05-08 EP EP01933173A patent/EP1286975B1/en not_active Expired - Lifetime
- 2001-05-08 HU HU0302323A patent/HUP0302323A2/hu unknown
- 2001-05-08 US US10/276,054 patent/US6794402B2/en not_active Expired - Fee Related
- 2001-05-08 DZ DZ013361A patent/DZ3361A1/fr active
- 2001-05-08 JP JP2002500853A patent/JP2003535083A/ja active Pending
- 2001-05-08 MX MXPA02011926A patent/MXPA02011926A/es active IP Right Grant
- 2001-05-08 CN CN01811676A patent/CN1438996A/zh active Pending
- 2001-05-08 SK SK1663-2002A patent/SK16632002A3/sk not_active Application Discontinuation
- 2001-05-08 AT AT01933173T patent/ATE302763T1/de not_active IP Right Cessation
- 2001-05-08 EE EEP200200667A patent/EE200200667A/xx unknown
- 2001-05-08 BR BR0111301-1A patent/BR0111301A/pt not_active IP Right Cessation
- 2001-05-08 AP APAP/P/2002/002697A patent/AP2002002697A0/en unknown
- 2001-05-08 PL PL01359260A patent/PL359260A1/pl not_active Application Discontinuation
- 2001-05-08 IL IL15317001A patent/IL153170A0/xx unknown
- 2001-05-08 AU AU2001259618A patent/AU2001259618A1/en not_active Abandoned
- 2001-05-08 OA OA1200200358A patent/OA12275A/en unknown
- 2001-05-08 WO PCT/US2001/014763 patent/WO2001092239A1/en active IP Right Grant
- 2001-05-08 ES ES01933173T patent/ES2245985T3/es not_active Expired - Lifetime
- 2001-05-08 KR KR1020027016301A patent/KR20030007797A/ko not_active Application Discontinuation
- 2001-05-08 DE DE60112924T patent/DE60112924T2/de not_active Expired - Fee Related
- 2001-05-08 CA CA002409006A patent/CA2409006A1/en not_active Abandoned
-
2002
- 2002-11-15 ZA ZA200209325A patent/ZA200209325B/en unknown
- 2002-11-18 IS IS6625A patent/IS6625A/is unknown
- 2002-11-27 MA MA26924A patent/MA26907A1/fr unknown
- 2002-11-29 NO NO20025762A patent/NO20025762L/no not_active Application Discontinuation
- 2002-12-11 BG BG107375A patent/BG107375A/bg unknown
- 2002-12-19 HR HR20021018A patent/HRP20021018A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1286975B1 (en) | 2005-08-24 |
ZA200209325B (en) | 2004-02-16 |
OA12275A (en) | 2003-12-11 |
ATE302763T1 (de) | 2005-09-15 |
WO2001092239A1 (en) | 2001-12-06 |
AP2002002697A0 (en) | 2002-12-31 |
SK16632002A3 (sk) | 2003-08-05 |
DE60112924T2 (de) | 2006-03-16 |
HRP20021018A2 (en) | 2004-02-29 |
BR0111301A (pt) | 2003-06-10 |
EP1286975A1 (en) | 2003-03-05 |
JP2003535083A (ja) | 2003-11-25 |
US6794402B2 (en) | 2004-09-21 |
NO20025762L (no) | 2003-01-09 |
NO20025762D0 (no) | 2002-11-29 |
MA26907A1 (fr) | 2004-12-20 |
CA2409006A1 (en) | 2001-12-06 |
CN1438996A (zh) | 2003-08-27 |
IL153170A0 (en) | 2003-06-24 |
HUP0302323A2 (hu) | 2003-10-28 |
US20030236252A1 (en) | 2003-12-25 |
KR20030007797A (ko) | 2003-01-23 |
BG107375A (bg) | 2003-09-30 |
EA200201158A1 (ru) | 2003-04-24 |
AU2001259618A1 (en) | 2001-12-11 |
DZ3361A1 (fr) | 2001-12-06 |
EE200200667A (et) | 2004-06-15 |
ES2245985T3 (es) | 2006-02-01 |
IS6625A (is) | 2002-11-18 |
MXPA02011926A (es) | 2003-04-22 |
DE60112924D1 (de) | 2005-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |