PL3368512T3 - Pochodne indoliny do leczenia i/albo zapobiegania chorobie zwłóknieniowej - Google Patents
Pochodne indoliny do leczenia i/albo zapobiegania chorobie zwłóknieniowejInfo
- Publication number
- PL3368512T3 PL3368512T3 PL15907425.1T PL15907425T PL3368512T3 PL 3368512 T3 PL3368512 T3 PL 3368512T3 PL 15907425 T PL15907425 T PL 15907425T PL 3368512 T3 PL3368512 T3 PL 3368512T3
- Authority
- PL
- Poland
- Prior art keywords
- prevention
- treatment
- indoline derivatives
- fibrosis diseases
- fibrosis
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000004761 fibrosis Effects 0.000 title 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/057600 WO2017074317A1 (en) | 2015-10-27 | 2015-10-27 | Indoline derivatives for treatment and/or prevention of fibrosis diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3368512T3 true PL3368512T3 (pl) | 2024-05-27 |
Family
ID=58630805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15907425.1T PL3368512T3 (pl) | 2015-10-27 | 2015-10-27 | Pochodne indoliny do leczenia i/albo zapobiegania chorobie zwłóknieniowej |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11278523B2 (pl) |
| EP (1) | EP3368512B1 (pl) |
| JP (2) | JP7302120B2 (pl) |
| CN (2) | CN108368043B (pl) |
| ES (1) | ES2965877T3 (pl) |
| HR (1) | HRP20240306T1 (pl) |
| HU (1) | HUE065418T2 (pl) |
| PL (1) | PL3368512T3 (pl) |
| RS (1) | RS65201B1 (pl) |
| TW (1) | TWI663973B (pl) |
| WO (1) | WO2017074317A1 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2965877T3 (es) * | 2015-10-27 | 2024-04-17 | Univ Taipei Medical | Derivados de indolina para el tratamiento y/o la prevención de enfermedades fibróticas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8158589B2 (en) * | 2003-08-22 | 2012-04-17 | Proyecto Biomedicine Cima, S.L. | Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1) |
| JP5220025B2 (ja) | 2006-12-04 | 2013-06-26 | プロメディオール， インコーポレイテッド | 線維症疾患を処置するための併用療法 |
| EP2100879A1 (en) * | 2008-03-13 | 2009-09-16 | 4Sc Ag | Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds |
| TWI429628B (zh) * | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| CA2848877A1 (en) | 2011-09-15 | 2013-03-21 | Taipei Medical University | Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury |
| JP6404208B2 (ja) * | 2012-03-27 | 2018-10-10 | ジェネンテック， インコーポレイテッド | 特発性肺線維症の予後予測、診断および処置の方法 |
| WO2014070983A1 (en) | 2012-10-31 | 2014-05-08 | The Regents Of The University Of Michigan | Plasminogen activator-1 inhibitors and methods of use thereof |
| CA2931345A1 (en) | 2013-11-24 | 2015-05-28 | Taipei Medical University | Use of indolyl and idolinyl hydroxamates for treating neurodegenerative disorders or cognitive deficits |
| US20150368195A1 (en) * | 2014-06-20 | 2015-12-24 | Taipei Medical University | Indoline compounds for treatment and/or prevention of inflammation diseases |
| ES2965877T3 (es) * | 2015-10-27 | 2024-04-17 | Univ Taipei Medical | Derivados de indolina para el tratamiento y/o la prevención de enfermedades fibróticas |
| CA3054839C (en) * | 2017-03-01 | 2023-08-29 | Chengdu Huitai Biomedicine Co., Ltd. | Polypeptides and uses thereof for treatment of a fibrosis disease |
-
2015
- 2015-10-27 ES ES15907425T patent/ES2965877T3/es active Active
- 2015-10-27 RS RS20240213A patent/RS65201B1/sr unknown
- 2015-10-27 CN CN201580084223.3A patent/CN108368043B/zh active Active
- 2015-10-27 JP JP2018521343A patent/JP7302120B2/ja active Active
- 2015-10-27 US US15/771,476 patent/US11278523B2/en active Active
- 2015-10-27 HU HUE15907425A patent/HUE065418T2/hu unknown
- 2015-10-27 HR HRP20240306TT patent/HRP20240306T1/hr unknown
- 2015-10-27 EP EP15907425.1A patent/EP3368512B1/en active Active
- 2015-10-27 PL PL15907425.1T patent/PL3368512T3/pl unknown
- 2015-10-27 WO PCT/US2015/057600 patent/WO2017074317A1/en active Application Filing
- 2015-10-27 CN CN202211450662.XA patent/CN116077489A/zh active Pending
- 2015-11-30 TW TW104139995A patent/TWI663973B/zh active
-
2021
- 2021-05-06 JP JP2021078805A patent/JP2021119190A/ja active Pending
-
2022
- 2022-03-02 US US17/653,251 patent/US20220184032A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN116077489A (zh) | 2023-05-09 |
| JP7302120B2 (ja) | 2023-07-04 |
| JP2018531959A (ja) | 2018-11-01 |
| ES2965877T3 (es) | 2024-04-17 |
| HRP20240306T1 (hr) | 2024-05-10 |
| US20180243264A1 (en) | 2018-08-30 |
| CN108368043A (zh) | 2018-08-03 |
| JP2021119190A (ja) | 2021-08-12 |
| HUE065418T2 (hu) | 2024-05-28 |
| TW201714614A (zh) | 2017-05-01 |
| EP3368512C0 (en) | 2023-12-06 |
| EP3368512A4 (en) | 2019-06-26 |
| EP3368512B1 (en) | 2023-12-06 |
| EP3368512A1 (en) | 2018-09-05 |
| US11278523B2 (en) | 2022-03-22 |
| WO2017074317A1 (en) | 2017-05-04 |
| TWI663973B (zh) | 2019-07-01 |
| US20220184032A1 (en) | 2022-06-16 |
| RS65201B1 (sr) | 2024-03-29 |
| CN108368043B (zh) | 2022-11-29 |
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