PL3138903T3 - Komórki do wytwarzania przeciwciała ludzkiego - Google Patents

Komórki do wytwarzania przeciwciała ludzkiego

Info

Publication number
PL3138903T3
PL3138903T3 PL15786546T PL15786546T PL3138903T3 PL 3138903 T3 PL3138903 T3 PL 3138903T3 PL 15786546 T PL15786546 T PL 15786546T PL 15786546 T PL15786546 T PL 15786546T PL 3138903 T3 PL3138903 T3 PL 3138903T3
Authority
PL
Poland
Prior art keywords
cells
human antibody
producing human
producing
antibody
Prior art date
Application number
PL15786546T
Other languages
English (en)
Inventor
Shuichi Hashimoto
Tomoaki Uchiki
Shigehisa Kawata
Kenjiro Asagoshi
Takashi Yabuki
Hitomi Sano
Shunsuke Miyai
Naoki Takahashi
Aki Takesue
Atsushi Sawada
Original Assignee
Chiome Bioscience Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiome Bioscience Inc. filed Critical Chiome Bioscience Inc.
Publication of PL3138903T3 publication Critical patent/PL3138903T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL15786546T 2014-05-02 2015-05-01 Komórki do wytwarzania przeciwciała ludzkiego PL3138903T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014095236 2014-05-02
EP15786546.0A EP3138903B1 (en) 2014-05-02 2015-05-01 Cells for producing human antibody
PCT/JP2015/063090 WO2015167011A1 (ja) 2014-05-02 2015-05-01 ヒト抗体を産生する細胞

Publications (1)

Publication Number Publication Date
PL3138903T3 true PL3138903T3 (pl) 2022-04-25

Family

ID=54358732

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15786546T PL3138903T3 (pl) 2014-05-02 2015-05-01 Komórki do wytwarzania przeciwciała ludzkiego

Country Status (10)

Country Link
US (2) US20170058029A1 (pl)
EP (2) EP3138903B1 (pl)
JP (2) JP6721502B2 (pl)
CN (2) CN112877292A (pl)
DK (1) DK3138903T3 (pl)
ES (1) ES2909766T3 (pl)
HU (1) HUE057708T2 (pl)
PL (1) PL3138903T3 (pl)
PT (1) PT3138903T (pl)
WO (1) WO2015167011A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018062495A1 (ja) * 2016-09-30 2018-04-05 株式会社カイオム・バイオサイエンス 抗体の取得方法
WO2018147432A1 (ja) 2017-02-10 2018-08-16 株式会社カイオム・バイオサイエンス 抗体可変領域の多様化を促進する方法
US12102070B2 (en) * 2018-06-13 2024-10-01 Crystal Bioscience Inc. Camelization of a human variable domain by gene conversion
AU2019284256B2 (en) * 2018-06-13 2025-08-28 Crystal Bioscience Inc. Transgenic chicken that makes antibodies with long CDR-H3S stabilized by multiple disulfide bridges and diversified by gene conversion
CA3101859A1 (en) * 2018-06-13 2019-12-19 Crystal Bioscience Inc. Production of antibodies by modification of an autonomous heavy chain variable domain by gene conversion
IL314512A (en) 2022-01-27 2024-09-01 Chiome Bioscience Inc Anti-human cxcl1 antibody
EP4540373A2 (en) * 2022-06-14 2025-04-23 Purdue Research Foundation Car-expressing pluripotent stem cell-derived neutrophils loaded with drug nanoparticles and uses thereof
CN120418290A (zh) 2022-12-22 2025-08-01 凯奥目生物科学株式会社 抗人cx3cr1抗体

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU718138B2 (en) 1995-08-29 2000-04-06 Kyowa Hakko Kirin Co., Ltd. Chimeric animal and method for constructing the same
US6285500B1 (en) 1999-06-29 2001-09-04 Corning Incorporated Wavelength selective switch
CA2422155A1 (en) * 2000-08-03 2002-02-14 Wim Van Schooten Production of humanized antibodies in transgenic animals
US20100310552A1 (en) * 2001-09-18 2010-12-09 Rapp Jeffrey C Antibodies produced in the avian oviduct
US20100333219A1 (en) * 2001-11-30 2010-12-30 Synageva Biopharma Corp. Methods of protein production using ovomucoid regulatory regions
IL162111A0 (en) * 2001-12-22 2005-11-20 4Antibody Ag Method for the generation of generically modified vertebrate precursor lymphocytes and use thereof for the production of heterologo
JP4214234B2 (ja) 2002-07-30 2009-01-28 独立行政法人理化学研究所 体細胞相同組換えの促進方法及び特異的抗体の作製方法
JP2004298072A (ja) 2003-03-31 2004-10-28 Nippon Del Monte Corp ポット菜園セット
CN1852925A (zh) * 2003-07-15 2006-10-25 人类多克隆治疗公司 人源化免疫球蛋白基因座
WO2008027986A2 (en) * 2006-09-01 2008-03-06 Therapeutic Human Polyclonals, Inc. Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
JP2008099602A (ja) * 2006-10-19 2008-05-01 Institute Of Physical & Chemical Research 抗体遺伝子の可変領域における変異部位の分布状況の調節法
US8088951B2 (en) * 2006-11-30 2012-01-03 Massachusetts Institute Of Technology Epigenetic mechanisms re-establish access to long-term memory after neuronal loss
WO2010019656A1 (en) * 2008-08-12 2010-02-18 Wyeth Humanized anti-rage antibody
EP2374881A4 (en) 2008-12-05 2013-03-13 Chiome Bioscience Inc METHOD FOR PRODUCING A CELL SURFACE EXPRESSED PROTEIN DIRECTED ANTIBODY
JP5756802B2 (ja) * 2009-08-13 2015-07-29 クリスタル バイオサイエンス インク．Ｃｒｙｓｔａｌ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ． 最小ｃｄｒを有する抗体を産生するトランスジェニック動物
JP5158816B2 (ja) * 2009-10-19 2013-03-06 国立大学法人 東京大学 キメラ抗体の一段階作製方法
CN102803488A (zh) * 2009-11-17 2012-11-28 协和发酵麒麟株式会社 人类人工染色体载体
JP2013511258A (ja) * 2009-11-19 2013-04-04 株式会社免疫工学研究所 所望のポリペプチドを産生する抗体産生細胞の製造方法
WO2011123708A2 (en) * 2010-03-31 2011-10-06 Ablexis Llc Genetic engineering of non-human animals for the production of chimeric antibodies
EP2641967B1 (en) * 2010-11-18 2016-10-12 National University Corporation Okayama University Method for preparing b cell which produces human-type antibody
EP2574666A1 (en) * 2011-09-23 2013-04-03 Protealmmun GmbH Method for producing antigen-specific antibodies via in vitro immunisation
WO2013138518A1 (en) * 2012-03-15 2013-09-19 Omeros Corporation Composition and method for diversification of target sequences

Also Published As

Publication number Publication date
JP6721502B2 (ja) 2020-07-15
DK3138903T3 (da) 2022-04-19
US20210332129A1 (en) 2021-10-28
EP3851453A1 (en) 2021-07-21
EP3138903A4 (en) 2017-11-01
HUE057708T2 (hu) 2022-05-28
CN112877292A (zh) 2021-06-01
CN106414717A (zh) 2017-02-15
ES2909766T3 (es) 2022-05-10
EP3138903B1 (en) 2022-02-09
JPWO2015167011A1 (ja) 2017-04-20
JP2020099341A (ja) 2020-07-02
PT3138903T (pt) 2022-03-21
EP3138903A1 (en) 2017-03-08
US20170058029A1 (en) 2017-03-02
JP7236741B2 (ja) 2023-03-10
CN106414717B (zh) 2021-05-04
WO2015167011A1 (ja) 2015-11-05

Similar Documents

Publication Publication Date Title
IL252004A0 (en) Ether-substituted antibody
IL250583A0 (en) Anti-tigit antibodies
IL246661B (en) Human antibodies to pd–l1
SG11201703403TA (en) Anti-tim-3 antibodies
SG11201703346PA (en) Anti-tim-3 antibodies
IL252422B (en) Effector-deficient anti-cd32a antibodies
GB201411320D0 (en) Antibody construct
IL246909A0 (en) Antibodies against il-21
PT3101132T (pt) Anticorpo humano anti-transtirretina
GB201410520D0 (en) Antibody
PL3138903T3 (pl) Komórki do wytwarzania przeciwciała ludzkiego
IL250374A0 (en) Antibodies against ceramide
IL248220A0 (en) Anti- nme antibody
PL3180356T3 (pl) Ludzkie przeciwciało anty-fgfr4
SG11201700922YA (en) Anti-orai1 antibody
GB201419089D0 (en) Anti-TIM-3 antibodies
GB201419092D0 (en) Anti-TIM-3 antibodies
GB201417614D0 (en) Antibodies
GB201414270D0 (en) Antibodies
GB201418776D0 (en) Antibody
GB201405775D0 (en) Antibodies
GB201413745D0 (en) Antibody
GB201401200D0 (en) Antibodies
GB201411319D0 (en) Antibody
GB201407535D0 (en) Antibody Drug - Conjugates