PL2997033T3 - Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv - Google Patents

Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv

Info

Publication number
PL2997033T3
PL2997033T3 PL14798188T PL14798188T PL2997033T3 PL 2997033 T3 PL2997033 T3 PL 2997033T3 PL 14798188 T PL14798188 T PL 14798188T PL 14798188 T PL14798188 T PL 14798188T PL 2997033 T3 PL2997033 T3 PL 2997033T3
Authority
PL
Poland
Prior art keywords
heterocyclic compounds
hiv integrase
integrase inhibitors
tricyclic heterocyclic
fused tricyclic
Prior art date
Application number
PL14798188T
Other languages
English (en)
Inventor
Paul J. Coleman
Timothy J. Hartingh
Izzat T. Raheem
John Schreier
John T. Sisko
John Wai
Thomas Graham
Lihong Hu
Xuanjia Peng
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of PL2997033T3 publication Critical patent/PL2997033T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PL14798188T 2013-05-17 2014-04-18 Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv PL2997033T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361824739P 2013-05-17 2013-05-17
EP14798188.0A EP2997033B1 (en) 2013-05-17 2014-04-18 Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
PCT/CN2014/075685 WO2014183532A1 (en) 2013-05-17 2014-04-18 Fused tricyclic heterocyclic compounds as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
PL2997033T3 true PL2997033T3 (pl) 2018-04-30

Family

ID=51897679

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14798188T PL2997033T3 (pl) 2013-05-17 2014-04-18 Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv

Country Status (19)

Country Link
US (1) US9643982B2 (pl)
EP (2) EP2997033B1 (pl)
AR (1) AR096332A1 (pl)
AU (1) AU2014267951A1 (pl)
CY (1) CY1119842T1 (pl)
DK (1) DK2997033T3 (pl)
ES (1) ES2656696T3 (pl)
HK (1) HK1248685A1 (pl)
HR (1) HRP20180081T1 (pl)
HU (1) HUE036384T2 (pl)
LT (1) LT2997033T (pl)
ME (1) ME02977B (pl)
NO (1) NO3058793T3 (pl)
PL (1) PL2997033T3 (pl)
PT (1) PT2997033T (pl)
RS (1) RS56701B1 (pl)
SI (1) SI2997033T1 (pl)
TW (1) TWI656122B (pl)
WO (1) WO2014183532A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3757105A3 (en) 2014-08-22 2021-01-06 Shionogi & Co., Ltd Polycyclic pyridone derivative having integrase inhibitory activity
TWI520963B (zh) * 2014-12-24 2016-02-11 國立清華大學 １，９－二氮萉衍生物及其製法
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
JOP20190130A1 (ar) * 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
WO2018102634A1 (en) 2016-12-02 2018-06-07 Merck Sharp & Dohme Corp. Tricyclic heterocycle compounds useful as hiv integrase inhibitors
EP3784241A4 (en) * 2018-04-27 2022-01-19 Merck Sharp & Dohme Corp. TETRACYCLIC HETEROCYCLENIC COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
PE20210477A1 (es) 2018-05-31 2021-03-11 Shionogi & Co Derivado policiclico de carbamoilpiridona
EA202092923A1 (ru) 2018-05-31 2021-04-09 Сионоги Энд Ко., Лтд. Полициклическое производное пиридона
US11884683B2 (en) 2018-06-05 2024-01-30 Merck Sharp & Dohme Llc Tricyclic heterocycle compounds useful as HIV integrase inhibitors
ES2951829T3 (es) 2018-06-21 2023-10-25 Hoffmann La Roche Formas sólidas de la sal de tartrato de 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropil)acetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol, proceso para su preparación y procedimientos de su uso en el tratamiento de cánceres
MX2021011394A (es) 2019-03-22 2021-10-13 Gilead Sciences Inc Compuestos de carbamoilpiridona triciclica puenteada y su uso farmaceutico.
US20200398978A1 (en) 2019-06-20 2020-12-24 Bell Helicopter Textron Inc. Low-drag rotor blade extension
TW202133858A (zh) 2019-11-28 2021-09-16 日商鹽野義製藥股份有限公司 以組合整合酶阻礙劑及抗ｈｉｖ藥為特徵之ｈｉｖ感染症的預防及治療用醫藥
CN115151545A (zh) 2020-02-24 2022-10-04 吉利德科学公司 用于治疗hiv感染的四环化合物
FI4196479T3 (fi) 2021-01-19 2024-01-17 Gilead Sciences Inc Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä

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ES2383262T3 (es) 2001-08-10 2012-06-19 Shionogi & Co., Ltd. Agente antiviral
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DK1441735T3 (da) 2001-10-26 2006-06-12 Angeletti P Ist Richerche Bio N-substituerede hydroxypyrimidinon-carboxamid-inhibitorer af HIV-integrase
ATE370948T1 (de) 2002-01-17 2007-09-15 Merck & Co Inc Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
MXPA05007010A (es) 2002-12-27 2005-08-18 Angeletti P Ist Richerche Bio Tetrahidro-4h-pirido[1,2-a]pirimidinas y compuestos relacionados utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana.
US7135467B2 (en) 2003-01-13 2006-11-14 Bristol-Myers Squibb Company HIV integrase inhibitors
US7037908B2 (en) 2003-04-24 2006-05-02 Bristol-Myers Squibb Company HIV integrase inhibitors
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AR046938A1 (es) 2003-12-12 2006-01-04 Merck & Co Inc Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
JP2007528379A (ja) * 2004-03-09 2007-10-11 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｈｉｖインテグラーゼ阻害薬
CN1929737A (zh) 2004-03-09 2007-03-14 默克公司 Hiv整合酶抑制剂
WO2005086700A2 (en) 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
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US7273859B2 (en) 2004-05-12 2007-09-25 Bristol-Myers Squibb Company HIV integrase inhibitors: cyclic pyrimidinone compounds
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US8039458B2 (en) 2005-11-17 2011-10-18 Bristol-Myers Squibb Company HIV integrase inhibitors
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US7893055B2 (en) 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
JP5624148B2 (ja) 2009-10-13 2014-11-12 エランコ・アニマル・ヘルス・アイルランド・リミテッド 大環状インテグラーゼ阻害剤
KR20120130185A (ko) 2010-02-26 2012-11-29 니뽄 다바코 산교 가부시키가이샤 １,３,４,８―테트라히드로―２Ｈ―피리도［１,２―ａ］피라진 유도체 및 그의 ＨＩＶ 인테그라제 저해제로서의 이용
CN102958935B (zh) 2010-04-02 2015-12-09 爱尔兰詹森科学公司 大环整合酶抑制剂

Also Published As

Publication number Publication date
RS56701B1 (sr) 2018-03-30
US9643982B2 (en) 2017-05-09
TWI656122B (zh) 2019-04-11
EP2997033B1 (en) 2017-11-15
LT2997033T (lt) 2018-02-12
TW201524978A (zh) 2015-07-01
ES2656696T3 (es) 2018-02-28
CY1119842T1 (el) 2018-06-27
EP2997033A1 (en) 2016-03-23
EP3330272A1 (en) 2018-06-06
AU2014267951A1 (en) 2015-11-19
ME02977B (me) 2018-10-20
DK2997033T3 (da) 2018-01-29
WO2014183532A1 (en) 2014-11-20
NO3058793T3 (pl) 2018-03-17
EP3330272B1 (en) 2021-02-17
PT2997033T (pt) 2018-01-25
US20160108059A1 (en) 2016-04-21
AR096332A1 (es) 2015-12-23
HK1248685A1 (zh) 2018-10-19
EP2997033A4 (en) 2016-10-26
HUE036384T2 (hu) 2018-07-30
HRP20180081T1 (hr) 2018-02-23
SI2997033T1 (en) 2018-04-30

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