PL2997033T3 - Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv - Google Patents
Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hivInfo
- Publication number
- PL2997033T3 PL2997033T3 PL14798188T PL14798188T PL2997033T3 PL 2997033 T3 PL2997033 T3 PL 2997033T3 PL 14798188 T PL14798188 T PL 14798188T PL 14798188 T PL14798188 T PL 14798188T PL 2997033 T3 PL2997033 T3 PL 2997033T3
- Authority
- PL
- Poland
- Prior art keywords
- heterocyclic compounds
- hiv integrase
- integrase inhibitors
- tricyclic heterocyclic
- fused tricyclic
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824739P | 2013-05-17 | 2013-05-17 | |
| PCT/CN2014/075685 WO2014183532A1 (en) | 2013-05-17 | 2014-04-18 | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| EP14798188.0A EP2997033B1 (en) | 2013-05-17 | 2014-04-18 | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2997033T3 true PL2997033T3 (pl) | 2018-04-30 |
Family
ID=51897679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14798188T PL2997033T3 (pl) | 2013-05-17 | 2014-04-18 | Skondensowane tricykliczne związki heterocykliczne jako inhibitory integrazy hiv |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9643982B2 (pl) |
| EP (2) | EP3330272B1 (pl) |
| AR (1) | AR096332A1 (pl) |
| AU (1) | AU2014267951A1 (pl) |
| CY (1) | CY1119842T1 (pl) |
| DK (1) | DK2997033T3 (pl) |
| ES (1) | ES2656696T3 (pl) |
| HK (1) | HK1248685A1 (pl) |
| HR (1) | HRP20180081T1 (pl) |
| HU (1) | HUE036384T2 (pl) |
| LT (1) | LT2997033T (pl) |
| ME (1) | ME02977B (pl) |
| NO (1) | NO3058793T3 (pl) |
| PL (1) | PL2997033T3 (pl) |
| PT (1) | PT2997033T (pl) |
| RS (1) | RS56701B1 (pl) |
| SI (1) | SI2997033T1 (pl) |
| TW (1) | TWI656122B (pl) |
| WO (1) | WO2014183532A1 (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3757105B1 (en) | 2014-08-22 | 2024-07-24 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase inhibitory activity |
| TWI520963B (zh) * | 2014-12-24 | 2016-02-11 | 國立清華大學 | １，９－二氮萉衍生物及其製法 |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| EP3548031B1 (en) * | 2016-12-02 | 2023-07-19 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| JOP20190130A1 (ar) * | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| JP2021522254A (ja) * | 2018-04-27 | 2021-08-30 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｈｉｖインテグラーゼ阻害剤として有用な三環式複素環化合物 |
| AU2019277547B2 (en) | 2018-05-31 | 2024-10-10 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative |
| PE20251594A1 (es) | 2018-05-31 | 2025-06-16 | Shionogi & Co | Derivado policiclico de carbamoilpiridona |
| US11884683B2 (en) | 2018-06-05 | 2024-01-30 | Merck Sharp & Dohme Llc | Tricyclic heterocycle compounds useful as HIV integrase inhibitors |
| DK3810283T3 (en) | 2018-06-21 | 2023-08-21 | Hoffmann La Roche | Faste former af tartratsalt af 3-((1R,3R)-1-(2,6-difluor-4-((1-(3-fluorpropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluorpropan-1-ol, proces¿.. |
| CN119462659A (zh) | 2019-03-22 | 2025-02-18 | 吉利德科学公司 | 桥连三环氨基甲酰基吡啶酮化合物及其药学用途 |
| US20200398978A1 (en) | 2019-06-20 | 2020-12-24 | Bell Helicopter Textron Inc. | Low-drag rotor blade extension |
| US12577241B2 (en) | 2019-11-28 | 2026-03-17 | Shionogi & Co., Ltd. | Polycyclic pyridopyrazine derivative |
| JPWO2021107066A1 (pl) | 2019-11-28 | 2021-06-03 | ||
| PE20221569A1 (es) | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| WO2022072520A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| LT4196479T (lt) | 2021-01-19 | 2023-12-11 | Gilead Sciences, Inc. | Pakeistieji piridotriazino junginiai ir jų panaudojimo būdai |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3042894T1 (da) | 2001-08-10 | 2016-11-07 | Shionogi & Co | Antiviralt middel |
| DK1441734T3 (da) | 2001-10-26 | 2007-06-11 | Angeletti P Ist Richerche Bio | Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase |
| CN102229605B (zh) | 2001-10-26 | 2015-01-14 | Msd意大利有限公司 | 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂 |
| AU2003216049B2 (en) | 2002-01-17 | 2008-07-17 | Merck Sharp & Dohme Corp. | Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors |
| EP1578748B1 (en) | 2002-12-27 | 2010-09-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors |
| WO2004062613A2 (en) | 2003-01-13 | 2004-07-29 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
| US7037908B2 (en) | 2003-04-24 | 2006-05-02 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| KR20070026414A (ko) * | 2004-03-09 | 2007-03-08 | 머크 앤드 캄파니 인코포레이티드 | Ｈｉｖ 인테그라제 억제제 |
| WO2005087766A1 (en) * | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
| WO2005086700A2 (en) * | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| US7820680B2 (en) * | 2004-03-09 | 2010-10-26 | Merck & Co., Inc. | HIV integrase inhibitors |
| US7273859B2 (en) | 2004-05-12 | 2007-09-25 | Bristol-Myers Squibb Company | HIV integrase inhibitors: cyclic pyrimidinone compounds |
| US7115601B2 (en) | 2004-05-18 | 2006-10-03 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7176196B2 (en) | 2004-05-28 | 2007-02-13 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7157447B2 (en) | 2004-05-28 | 2007-01-02 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7173022B2 (en) | 2004-05-28 | 2007-02-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7192948B2 (en) | 2004-05-28 | 2007-03-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| AU2006228278C1 (en) | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
| US7494984B2 (en) | 2005-08-31 | 2009-02-24 | Bristol-Myers Squibb Company | Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors |
| WO2007059125A2 (en) | 2005-11-15 | 2007-05-24 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
| US7902182B2 (en) | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8039458B2 (en) | 2005-11-17 | 2011-10-18 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| WO2007143446A1 (en) | 2006-05-30 | 2007-12-13 | Bristol-Myers Squibb Company | Spiro-condensed heterotricyclic compounds as hiv integrase inhibitors |
| US7893055B2 (en) | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| CA2777664C (en) | 2009-10-13 | 2014-06-10 | Johannes Wilhelmus J. Thuring | Macrocyclic integrase inhibitors |
| KR20120130185A (ko) | 2010-02-26 | 2012-11-29 | 니뽄 다바코 산교 가부시키가이샤 | １,３,４,８―테트라히드로―２Ｈ―피리도［１,２―ａ］피라진 유도체 및 그의 ＨＩＶ 인테그라제 저해제로서의 이용 |
| BR112012024796A2 (pt) | 2010-04-02 | 2016-06-07 | Janssen R&D Ireland | inibidores de integrase macrocíclicos |
-
2014
- 2014-04-18 EP EP17201148.8A patent/EP3330272B1/en active Active
- 2014-04-18 HR HRP20180081TT patent/HRP20180081T1/hr unknown
- 2014-04-18 LT LTEP14798188.0T patent/LT2997033T/lt unknown
- 2014-04-18 WO PCT/CN2014/075685 patent/WO2014183532A1/en not_active Ceased
- 2014-04-18 US US14/892,754 patent/US9643982B2/en active Active
- 2014-04-18 ME MEP-2018-4A patent/ME02977B/me unknown
- 2014-04-18 DK DK14798188.0T patent/DK2997033T3/da active
- 2014-04-18 PT PT147981880T patent/PT2997033T/pt unknown
- 2014-04-18 RS RS20180010A patent/RS56701B1/sr unknown
- 2014-04-18 EP EP14798188.0A patent/EP2997033B1/en active Active
- 2014-04-18 HU HUE14798188A patent/HUE036384T2/hu unknown
- 2014-04-18 PL PL14798188T patent/PL2997033T3/pl unknown
- 2014-04-18 SI SI201430563T patent/SI2997033T1/en unknown
- 2014-04-18 ES ES14798188.0T patent/ES2656696T3/es active Active
- 2014-04-18 AU AU2014267951A patent/AU2014267951A1/en not_active Abandoned
- 2014-05-15 TW TW103117219A patent/TWI656122B/zh not_active IP Right Cessation
- 2014-05-16 AR ARP140101973A patent/AR096332A1/es not_active Application Discontinuation
-
2015
- 2015-01-28 NO NO15704618A patent/NO3058793T3/no unknown
-
2018
- 2018-01-24 CY CY20181100097T patent/CY1119842T1/el unknown
- 2018-06-26 HK HK18108172.3A patent/HK1248685A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS56701B1 (sr) | 2018-03-30 |
| HRP20180081T1 (hr) | 2018-02-23 |
| EP2997033B1 (en) | 2017-11-15 |
| EP2997033A4 (en) | 2016-10-26 |
| EP3330272A1 (en) | 2018-06-06 |
| US20160108059A1 (en) | 2016-04-21 |
| AU2014267951A1 (en) | 2015-11-19 |
| WO2014183532A1 (en) | 2014-11-20 |
| TWI656122B (zh) | 2019-04-11 |
| DK2997033T3 (da) | 2018-01-29 |
| NO3058793T3 (pl) | 2018-03-17 |
| EP3330272B1 (en) | 2021-02-17 |
| HK1248685A1 (en) | 2018-10-19 |
| US9643982B2 (en) | 2017-05-09 |
| AR096332A1 (es) | 2015-12-23 |
| HUE036384T2 (hu) | 2018-07-30 |
| CY1119842T1 (el) | 2018-06-27 |
| SI2997033T1 (en) | 2018-04-30 |
| EP2997033A1 (en) | 2016-03-23 |
| TW201524978A (zh) | 2015-07-01 |
| ES2656696T3 (es) | 2018-02-28 |
| PT2997033T (pt) | 2018-01-25 |
| ME02977B (me) | 2018-10-20 |
| LT2997033T (lt) | 2018-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3008044A4 (en) | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors | |
| PT2997033T (pt) | Compostos heterocíclicos tricíclicos fundidos como inibidores de vih integrase | |
| ZA201601708B (en) | Substituted quinolizine derivatives useful as hiv integrase inhibitors | |
| IL239457A0 (en) | Novel heterocyclic compounds as bromodomain inhibitors | |
| EP3083641A4 (en) | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors | |
| SG11201605654QA (en) | Fused heterocyclic compound | |
| IL266908A (en) | Heterocyclic tetracyclic compounds for use as hiv integrase inhibitors | |
| IL265496A (en) | bace1 inhibitors | |
| ZA201508396B (en) | Heterocyclic compounds as hedgehog signaling pathway inhibitors | |
| IL245379A0 (en) | Heterocyclic n-acylamino compounds | |
| IL245301A0 (en) | New heterocyclic compounds | |
| ZA201508864B (en) | Substituted heterocyclic compounds as crac modulators | |
| IL254424A0 (en) | Disubstituted heterocyclic tricyclic compounds | |
| IL240612A0 (en) | Tricyclic heterocycles as anti-cancer agents | |
| SI3063139T1 (sl) | Heterociklična spojina | |
| IL244347A0 (en) | n-acylamino heterocyclic compounds | |
| IL241962B (en) | Heterocyclic acetamide compound | |
| GB201322752D0 (en) | Novel ferrocenyl compounds | |
| GB201309960D0 (en) | Novel pyrrole derivatives | |
| GB201309935D0 (en) | Novel pyrrole derivatives | |
| GB201314960D0 (en) | Heterocyclic derivatives | |
| GB201300306D0 (en) | Heterocyclic derivatives | |
| GB201300649D0 (en) | Cyclization | |
| GB201309959D0 (en) | Novel pyrrole derivatives | |
| GB201309934D0 (en) | Novel pyrrole derivatives |