PL2970232T3 - Podstawione pochodne pirydyny użyteczne jako inhibitory kinazy c-FMS - Google Patents
Podstawione pochodne pirydyny użyteczne jako inhibitory kinazy c-FMSInfo
- Publication number
- PL2970232T3 PL2970232T3 PL14729096T PL14729096T PL2970232T3 PL 2970232 T3 PL2970232 T3 PL 2970232T3 PL 14729096 T PL14729096 T PL 14729096T PL 14729096 T PL14729096 T PL 14729096T PL 2970232 T3 PL2970232 T3 PL 2970232T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- pyridine derivatives
- substituted pyridine
- derivatives useful
- fms kinase
- Prior art date
Links
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- AIDS & HIV (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791007P | 2013-03-15 | 2013-03-15 | |
| EP14729096.9A EP2970232B1 (en) | 2013-03-15 | 2014-03-13 | Substituted pyridine derivatives useful as c-fms kinase inhibitors |
| PCT/US2014/025308 WO2014151258A1 (en) | 2013-03-15 | 2014-03-13 | Substituted pyridine derivatives useful as c-fms kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2970232T3 true PL2970232T3 (pl) | 2018-08-31 |
Family
ID=50897867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14729096T PL2970232T3 (pl) | 2013-03-15 | 2014-03-13 | Podstawione pochodne pirydyny użyteczne jako inhibitory kinazy c-FMS |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9611259B2 (pl) |
| EP (2) | EP2970232B1 (pl) |
| JP (1) | JP6384022B2 (pl) |
| CN (2) | CN108341805A (pl) |
| AU (1) | AU2014235183B9 (pl) |
| CY (1) | CY1120185T1 (pl) |
| DK (1) | DK2970232T3 (pl) |
| ES (1) | ES2662600T3 (pl) |
| HK (2) | HK1250986A1 (pl) |
| HR (1) | HRP20180632T1 (pl) |
| HU (1) | HUE036925T2 (pl) |
| LT (1) | LT2970232T (pl) |
| MX (1) | MX365315B (pl) |
| NO (1) | NO3090256T3 (pl) |
| PL (1) | PL2970232T3 (pl) |
| PT (1) | PT2970232T (pl) |
| RS (1) | RS57103B1 (pl) |
| SI (1) | SI2970232T1 (pl) |
| SM (1) | SMT201800165T1 (pl) |
| WO (1) | WO2014151258A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9611259B2 (en) | 2013-03-15 | 2017-04-04 | Janssen Pharmaceutica Nv | Substituted pyridine derivatives useful as C-FMS kinase inhibitors |
| TW201811326A (zh) * | 2016-07-18 | 2018-04-01 | 比利時商健生藥品公司 | ４－氰基－ｎ－（２－（４，４－二甲基環己－１－烯－１－基）－６－（２，２，６，６－四甲基四氫－２ｈ－哌喃－４－基）吡啶－３－基）－１ｈ－咪唑－２－甲醯胺之鹽形式 |
| TWI752980B (zh) * | 2016-07-18 | 2022-01-21 | 比利時商健生藥品公司 | 4-氰基-n-(2-(4,4-二甲基環己-1-烯-1-基)-6-(2,2,6,6-四甲基四氫-2h-哌喃-4-基)吡啶-3-基)-1h-咪唑-2-甲醯胺之晶型 |
| WO2018160917A1 (en) * | 2017-03-03 | 2018-09-07 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer |
| WO2018182527A1 (en) * | 2017-03-30 | 2018-10-04 | National University Of Singapore | Method for treating inflammatory complications in eye diseases |
| WO2024254440A1 (en) * | 2023-06-09 | 2024-12-12 | Modulo Bio, Inc. | 5-cyano-1h-imidazole-2-carboxamide compounds as csf1r inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| CN101437514B (zh) * | 2004-10-22 | 2012-04-25 | 詹森药业有限公司 | C-fms激酶抑制剂 |
| JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| WO2009058968A2 (en) * | 2007-10-31 | 2009-05-07 | Janssen Pharmaceutica N.V. | Biomarker for assessing response to fms treatment |
| US9611259B2 (en) | 2013-03-15 | 2017-04-04 | Janssen Pharmaceutica Nv | Substituted pyridine derivatives useful as C-FMS kinase inhibitors |
-
2014
- 2014-03-13 US US14/772,040 patent/US9611259B2/en not_active Expired - Fee Related
- 2014-03-13 CN CN201810396318.4A patent/CN108341805A/zh active Pending
- 2014-03-13 ES ES14729096.9T patent/ES2662600T3/es active Active
- 2014-03-13 PT PT147290969T patent/PT2970232T/pt unknown
- 2014-03-13 RS RS20180441A patent/RS57103B1/sr unknown
- 2014-03-13 WO PCT/US2014/025308 patent/WO2014151258A1/en not_active Ceased
- 2014-03-13 EP EP14729096.9A patent/EP2970232B1/en active Active
- 2014-03-13 EP EP17190920.3A patent/EP3284742A1/en not_active Withdrawn
- 2014-03-13 MX MX2015012343A patent/MX365315B/es active IP Right Grant
- 2014-03-13 PL PL14729096T patent/PL2970232T3/pl unknown
- 2014-03-13 SM SM20180165T patent/SMT201800165T1/it unknown
- 2014-03-13 SI SI201430613T patent/SI2970232T1/en unknown
- 2014-03-13 DK DK14729096.9T patent/DK2970232T3/en active
- 2014-03-13 JP JP2016501816A patent/JP6384022B2/ja not_active Expired - Fee Related
- 2014-03-13 AU AU2014235183A patent/AU2014235183B9/en not_active Ceased
- 2014-03-13 HR HRP20180632TT patent/HRP20180632T1/hr unknown
- 2014-03-13 LT LTEP14729096.9T patent/LT2970232T/lt unknown
- 2014-03-13 HU HUE14729096A patent/HUE036925T2/hu unknown
- 2014-03-13 CN CN201480015688.9A patent/CN105026388B/zh not_active Expired - Fee Related
- 2014-12-02 NO NO14824967A patent/NO3090256T3/no unknown
-
2017
- 2017-02-23 US US15/440,182 patent/US10071991B2/en active Active
-
2018
- 2018-04-27 CY CY20181100448T patent/CY1120185T1/el unknown
- 2018-08-13 US US16/102,005 patent/US10800764B2/en active Active
- 2018-08-15 HK HK18110479.9A patent/HK1250986A1/en unknown
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2019
- 2019-01-28 HK HK19101388.7A patent/HK1258911A1/zh unknown
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2020
- 2020-09-02 US US17/010,132 patent/US11214566B2/en not_active Expired - Fee Related
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