PL2895503T3 - Fibronectin based scaffold domain proteins that bind to myostatin - Google Patents

Fibronectin based scaffold domain proteins that bind to myostatin

Info

Publication number
PL2895503T3
PL2895503T3 PL13767190T PL13767190T PL2895503T3 PL 2895503 T3 PL2895503 T3 PL 2895503T3 PL 13767190 T PL13767190 T PL 13767190T PL 13767190 T PL13767190 T PL 13767190T PL 2895503 T3 PL2895503 T3 PL 2895503T3
Authority
PL
Poland
Prior art keywords
myostatin
bind
domain proteins
based scaffold
scaffold domain
Prior art date
Application number
PL13767190T
Other languages
Polish (pl)
Inventor
Sharon Cload
Linda Engle
Dasa Lipovsek
Malavi Madireddi
Ginger Chao RAKESTRAW
Joanna SWAIN
Wenjun Zhao
Hui WEI
Aaron P. Yamniuk
Alexander T. Kozhich
Vidhyashankar Ramamurthy
Martin J. Corbett
Stanley Richard KRYSTEK Jr.
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49253416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2895503(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL2895503T3 publication Critical patent/PL2895503T3/en

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    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
PL13767190T 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin PL2895503T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261700697P 2012-09-13 2012-09-13
US201361780005P 2013-03-13 2013-03-13
EP13767190.5A EP2895503B1 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin
PCT/US2013/059458 WO2014043344A1 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin

Publications (1)

Publication Number Publication Date
PL2895503T3 true PL2895503T3 (en) 2019-09-30

Family

ID=49253416

Family Applications (3)

Application Number Title Priority Date Filing Date
PL19162848T PL3564258T3 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin
PL20206702.1T PL3835310T3 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin
PL13767190T PL2895503T3 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PL19162848T PL3564258T3 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin
PL20206702.1T PL3835310T3 (en) 2012-09-13 2013-09-12 Fibronectin based scaffold domain proteins that bind to myostatin

Country Status (33)

Country Link
US (9) US8853154B2 (en)
EP (4) EP3835310B1 (en)
JP (2) JP6346895B2 (en)
KR (3) KR102187714B1 (en)
CN (2) CN104768969B (en)
AU (2) AU2013315482B2 (en)
BR (1) BR112015005466B1 (en)
CA (1) CA2884730C (en)
CL (1) CL2015000500A1 (en)
DK (3) DK3835310T3 (en)
EA (1) EA033536B1 (en)
ES (3) ES2879387T3 (en)
FI (1) FI3835310T3 (en)
HR (3) HRP20190845T1 (en)
HU (3) HUE043482T2 (en)
IL (3) IL270110B (en)
LT (3) LT3835310T (en)
MX (2) MX390017B (en)
MY (2) MY189682A (en)
NZ (1) NZ628446A (en)
PE (1) PE20150954A1 (en)
PH (1) PH12015500397B1 (en)
PL (3) PL3564258T3 (en)
PT (3) PT3835310T (en)
RS (3) RS62009B1 (en)
SG (3) SG10201913685YA (en)
SI (3) SI3835310T1 (en)
SM (1) SMT202400214T1 (en)
TN (1) TN2015000086A1 (en)
TW (2) TWI633117B (en)
UY (2) UY40128A (en)
WO (1) WO2014043344A1 (en)
ZA (1) ZA201501457B (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10515A (en) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
MX336725B (en) 2007-09-26 2016-01-28 Chugai Pharmaceutical Co Ltd Method of modifying isoelectric point of antibody via amino acid substitution in cdr.
TWI700293B (en) 2008-04-11 2020-08-01 日商中外製藥股份有限公司 Antibodies that repeatedly bind to multiple antigens
ES2573108T3 (en) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Fibronectin-based framework proteins that have improved stability
KR102568454B1 (en) 2010-11-30 2023-08-18 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
EP2697257B1 (en) 2011-04-13 2016-10-19 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
TWI855488B (en) 2012-08-24 2024-09-11 日商中外製藥股份有限公司 Fcγriib-specific fc region variant
EP3597747B1 (en) 2012-08-24 2023-03-15 Chugai Seiyaku Kabushiki Kaisha Mouse fcgammarii-specific fc antibody
US8853154B2 (en) 2012-09-13 2014-10-07 Bristol-Myers Squibb Company Fibronectin based scaffold domain proteins that bind to myostatin
WO2014116981A1 (en) 2013-01-25 2014-07-31 Shire Human Genetic Therapies, Inc. Follistatin in treating duchenne muscular dystrophy
US20150361159A1 (en) 2013-02-01 2015-12-17 Bristol-Myers Squibb Company Fibronectin based scaffold proteins
US10787498B2 (en) 2013-02-06 2020-09-29 Bristol-Myers Squibb Company Fibronectin type III domain proteins with enhanced solubility
EP3299378B1 (en) 2013-02-12 2019-07-31 Bristol-Myers Squibb Company High ph protein refolding methods
AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
SMT202100008T1 (en) 2013-05-06 2021-03-15 Scholar Rock Inc Compositions and methods for growth factor modulation
MX378753B (en) 2014-03-20 2025-03-10 Bristol Myers Squibb Co FIBRONECTIN TYPE III DOMAINS THAT BIND SERUM ALBUMIN.
CN115322253A (en) 2014-03-20 2022-11-11 百时美施贵宝公司 Stabilized fibronectin-based scaffold molecules
WO2015161108A1 (en) * 2014-04-16 2015-10-22 The Scripps Research Institute Pparg modulators for treatment of osteoporosis
WO2016018917A2 (en) 2014-07-28 2016-02-04 The Regents Of The University Of Califoria Compositions and methods of making polymerized nucleic acids
US10980744B2 (en) 2014-08-08 2021-04-20 The Regents Of The University Of California High density peptide polymers
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
LT3221346T (en) 2014-11-21 2020-11-10 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
HUE050596T2 (en) 2014-11-21 2020-12-28 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
ES2822990T3 (en) 2014-11-25 2021-05-05 Bristol Myers Squibb Co Novel PD-L1 Binding Polypeptides for Imaging
EA034516B1 (en) 2014-11-25 2020-02-14 Бристол-Маерс Сквибб Компани Methods and compositions forf-radiolabeling of biologics
TWI656133B (en) 2014-12-19 2019-04-11 日商中外製藥股份有限公司 Anti-myostatin antibody, multi-peptide containing variant Fc region and method of use
AR103268A1 (en) 2014-12-23 2017-04-26 Bristol Myers Squibb Co ANTIBODIES AGAINST TIGIT
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10993993B2 (en) * 2015-05-28 2021-05-04 Immunoforge Co., Ltd. Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist
UY36687A (en) 2015-05-29 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware ANTIBODIES AGAINST OX40 AND ITS USES
KR20180021833A (en) 2015-06-29 2018-03-05 더 락커펠러 유니버시티 Antibodies to CD40 with enhanced agonist activity
WO2017040332A1 (en) * 2015-08-28 2017-03-09 University Of Massachusetts Quantifying net axonal transport in motor neuron pathologies
ES2809125T3 (en) * 2015-09-23 2021-03-03 Bristol Myers Squibb Co Glypican-3 binding fibronectin-based scaffold molecules
JP2018536404A (en) 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Method for manipulating quality characteristics of polypeptides produced in CHO cells
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
IL295230A (en) 2016-03-04 2022-10-01 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
IL261602B2 (en) 2016-03-04 2024-06-01 Univ Rockefeller CD40 antibodies with increased agonistic activity
RU2613420C1 (en) * 2016-04-13 2017-03-16 Сергей Михайлович Юдин RECOMBINANT PROTEIN Mio-HSP, METHOD OF ITS PRODUCTION, INJECTION PREPARATION FOR MUSCLE MASS INCREASE IN FARM ANIMALS, BIRDS AND ANIMALS OF CANIDS, AS WELL AS METHOD OF USING PREPARATION
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US10513537B2 (en) 2016-05-11 2019-12-24 Ge Healthcare Bioprocess R&D Ab Separation matrix
CN109311949B (en) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 Methods of storing separation matrices
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
JP7031934B2 (en) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
WO2017194593A1 (en) 2016-05-11 2017-11-16 Ge Healthcare Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
KR102397783B1 (en) 2016-06-01 2022-05-12 브리스톨-마이어스 스큅 컴퍼니 PET Imaging with PD-L1 Binding Polypeptides
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
JP2019528311A (en) * 2016-08-03 2019-10-10 ネクストキュア インコーポレイテッド Compositions and methods for modulating LAIR signaling
CN109689099B (en) 2016-08-05 2023-02-28 中外制药株式会社 Composition for preventing or treating IL-8 related diseases
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
CN110234334B (en) * 2016-12-05 2024-02-06 大塚制药株式会社 Muscle atrophy inhibiting composition
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
TWI897843B (en) * 2017-05-03 2025-09-21 美商必治妥美雅史谷比公司 Stable formulations of fibronectin based scaffold domain proteins that bind to myostatin
MX2019013132A (en) 2017-05-25 2020-01-27 Bristol Myers Squibb Co ANTIBODIES INCLUDING MODIFIED HEAVY CONSTANT REGIONS.
CN111788227B (en) 2017-12-27 2025-02-25 百时美施贵宝公司 Anti-CD40 antibodies and uses thereof
MX2020005193A (en) 2018-01-25 2020-08-20 I Mab Biopharma Us Ltd Anti-pd-l1 antibody and il-7 fusions.
CN108593615A (en) * 2018-05-02 2018-09-28 浠思（上海）生物技术有限公司 The method for screening PD1/PD-L1 blocking agents using HTRF one-step method
JP7051656B2 (en) 2018-09-28 2022-04-11 三菱重工コンプレッサ株式会社 Turbine stators, steam turbines, and dividers
MY205758A (en) 2018-11-16 2024-11-12 Bristol Myers Squibb Co Anti-nkg2a antibodies and uses thereof
US20220106400A1 (en) 2018-11-28 2022-04-07 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
US12516145B2 (en) 2019-09-30 2026-01-06 Northwestern University Bioactive peptide brush polymers via photoinduced reversible-deactivation radical polymerization
WO2021183428A1 (en) 2020-03-09 2021-09-16 Bristol-Myers Squibb Company Antibodies to cd40 with enhanced agonist activity
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
US11566346B2 (en) * 2020-06-25 2023-01-31 Philip David Rodley Protein scaffold
EP4247851A1 (en) * 2020-11-20 2023-09-27 Zoetis Services LLC Bovine antibody variants
CA3255225A1 (en) 2022-04-04 2023-10-12 The Regents Of The University Of California Genetic complementation compositions and methods
WO2025177263A1 (en) 2024-02-25 2025-08-28 Biohaven Therapeutics Ltd. Myostatin-binding proteins
WO2025219859A1 (en) 2024-04-14 2025-10-23 Biohaven Therapeutics Ltd. Combination therapy to treat overweight, obesity, and related health conditions

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US5672502A (en) 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US5514581A (en) 1986-11-04 1996-05-07 Protein Polymer Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5641648A (en) 1986-11-04 1997-06-24 Protein Polymer Technologies, Inc. Methods for preparing synthetic repetitive DNA
US5770697A (en) 1986-11-04 1998-06-23 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
US5589173A (en) 1986-11-04 1996-12-31 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US6018030A (en) 1986-11-04 2000-01-25 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
JP3051145B2 (en) 1990-08-28 2000-06-12 住友製薬株式会社 Novel polyethylene glycol derivative modified peptide
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5792742A (en) 1991-06-14 1998-08-11 New York University Fibrin-binding peptide fragments of fibronectin
WO2002081494A1 (en) 2001-03-26 2002-10-17 Sirna Therapeutics, Inc. Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication
EP1005870B1 (en) 1992-11-13 2009-01-21 Biogen Idec Inc. Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
WO1994017097A1 (en) 1993-01-19 1994-08-04 Regents Of The University Of Minnesota Synthetic fibronectin fragments as inhibitors of retroviral infections
US6673534B1 (en) 1995-10-26 2004-01-06 The Johns Hopkins University School Of Medicine Methods for detection of mutations in myostatin variants
ES2201076T3 (en) 1993-03-19 2004-03-16 The Johns Hopkins University School Of Medicine GROWTH DIFFERENTIATION FACTOR-8.
US6465239B1 (en) 1993-03-19 2002-10-15 The John Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
US6607884B1 (en) 1993-03-19 2003-08-19 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-8
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US20030074680A1 (en) 1993-03-19 2003-04-17 Johns Hopkins University School Of Medicine Growth differentiation factor-8
US5994618A (en) 1997-02-05 1999-11-30 Johns Hopkins University School Of Medicine Growth differentiation factor-8 transgenic mice
US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
ATE529509T1 (en) 1997-01-21 2011-11-15 Gen Hospital Corp SELECTION OF PROTEINS USING RNA-PROTEIN FUSIONS
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
WO1998033887A1 (en) 1997-02-05 1998-08-06 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
US7749498B2 (en) 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
WO1998056915A2 (en) 1997-06-12 1998-12-17 Research Corporation Technologies, Inc. Artificial antibody polypeptides
AU3463699A (en) 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
AU765214B2 (en) 1998-05-06 2003-09-11 Metamorphix International, Inc. Methods for treating diabetes by inhibiting gdf-8
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
DK1137941T4 (en) 1998-12-10 2014-01-06 Brystol Myers Squibb Company Protein scaffolds for antibody mimetics and other binding proteins
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
JP2003528632A (en) 2000-03-31 2003-09-30 インスティティ・パスツール Peptide inhibiting vascular endothelial growth factor (VEGF) -mediated angiogenesis, polynucleotide encoding the peptide and methods of use
AU7786701A (en) 2000-07-11 2002-01-21 Res Corp Technologies Inc Artificial antibody polypeptides
JP2004526419A (en) 2000-10-16 2004-09-02 フィロス インク． Protein scaffolds for antibody mimics and other binding proteins
US7598352B2 (en) 2000-11-17 2009-10-06 University Of Rochester Method of identifying polypeptide monobodies which bind to target proteins and use thereof
EP1572718A4 (en) 2001-04-04 2006-03-15 Univ Rochester BINDING POLYPEPTIDE MONOCORPS WITH INTEGRIN ALPHA NU BETA3 AND USE THEREOF
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
WO2003104418A2 (en) 2002-06-06 2003-12-18 Research Corporation Technologies, Inc. Reconstituted polypeptides
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
AR047392A1 (en) 2002-10-22 2006-01-18 Wyeth Corp NEUTRALIZATION OF ANTIBODIES AGAINST GDF 8 AND ITS USE FOR SUCH PURPOSES
US20070178082A1 (en) 2002-11-08 2007-08-02 Ablynx N.V. Stabilized single domain antibodies
US20080220049A1 (en) 2003-12-05 2008-09-11 Adnexus, A Bristol-Myers Squibb R&D Company Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
JP5006651B2 (en) 2003-12-05 2012-08-22 ブリストル−マイヤーズ スクウィブ カンパニー Inhibitor of type 2 vascular endothelial growth factor receptor
EP1729795B1 (en) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20070178095A1 (en) 2004-03-23 2007-08-02 Eli Lilly And Company Anti-myostatin antibodies
WO2005118646A2 (en) 2004-04-26 2005-12-15 Centocor, Inc. Epitope directed selection of antibodies to murine tissue factor
EP1804751A2 (en) 2004-10-04 2007-07-11 QLT USA, Inc. Ocular delivery of polymeric delivery formulations
NZ538097A (en) 2005-02-07 2006-07-28 Ovita Ltd Method and compositions for improving wound healing
BRPI0610248A2 (en) 2005-04-25 2010-06-08 Pfizer antibodies to myostatin, pharmaceutical composition comprising them, cell lines producing them, nucleic acid molecules encoding them as well as their uses
EP1915397B1 (en) 2005-08-19 2015-01-14 Wyeth LLC Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders
ES2533464T3 (en) 2005-10-06 2015-04-10 Eli Lilly And Company Anti-myostatin antibodies
UA92504C2 (en) 2005-10-12 2010-11-10 Эли Лилли Энд Компани Anti-myostatin monoclonal antibody
CA2632544C (en) 2005-12-06 2014-09-23 Amgen Inc. Use of myostatin antagonist for treating the effects of hypogonadism
US20070269422A1 (en) 2006-05-17 2007-11-22 Ablynx N.V. Serum albumin binding proteins with long half-lives
UA98308C2 (en) 2006-09-05 2012-05-10 Эли Лилли Энд Компани Anti-myostatin antibody
WO2008031098A1 (en) 2006-09-09 2008-03-13 The University Of Chicago Binary amino acid libraries for fibronectin type iii polypeptide monobodies
EP2121743B1 (en) 2006-11-22 2015-06-03 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
ATE516814T1 (en) 2007-02-02 2011-08-15 Bristol Myers Squibb Co 10FN3 DOMAIN FOR THE TREATMENT OF DISEASES ACCOMPANIED BY UNDESIRABLE ANGIOGENESIS
JP5591691B2 (en) 2007-05-22 2014-09-17 アムジエン・インコーポレーテツド Compositions and methods for making biologically active fusion proteins
EP2222846B1 (en) 2007-08-10 2017-05-03 Protelix, Inc. Universal fibronectin type iii binding-domain libraries
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US8680019B2 (en) 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
EP2197476A2 (en) 2007-08-20 2010-06-23 Bristol-Myers Squibb Company Use of vegfr-2 inhibitors for treating metastatic cancer
KR100857861B1 (en) * 2007-10-15 2008-09-11 주식회사 바이오리더스 Vector for surface expression of fusion protein of MYC-2 peptide polymer and myostatin and microorganism transformed with the vector
MX2010004374A (en) 2007-10-31 2010-04-30 Medimmune Llc Protein scaffolds.
PE20091163A1 (en) 2007-11-01 2009-08-09 Wyeth Corp ANTIBODIES FOR GDF8
WO2009073115A1 (en) 2007-11-28 2009-06-11 Bristol-Myers Squibb Company Combination vegfr2 therapy with mtor inhibitors
CA2709994A1 (en) 2007-12-19 2009-07-09 Centocor Ortho Biotech Inc. Non-antibody scaffold protein fusions phage display via fusion to pix of m13 phage
EA201000979A1 (en) 2007-12-27 2011-02-28 Новартис Аг IMPROVED BINDING MOLECULES BASED ON FIBRONECTIN AND THEIR APPLICATION
EP2080812A1 (en) 2008-01-18 2009-07-22 Transmedi SA Compositions and methods of detecting post-stop peptides
KR20100128291A (en) 2008-02-14 2010-12-07 브리스톨-마이어스 스큅 컴퍼니 Targeted Therapeutics Based on Engineered Proteins That Bind to EVFR
CN102076713B (en) 2008-05-02 2015-03-25 诺华股份有限公司 Improved fibronectin-based binding molecules and uses thereof
CN102099373A (en) 2008-05-22 2011-06-15 百时美施贵宝公司 Multivalent fibronectin based scaffold domain proteins
BRPI0919881B1 (en) 2008-10-31 2021-09-08 Centocor Ortho Biotech Inc FRAMEWORK PROTEIN AND ITS GENERATION METHOD, LIBRARY AND ITS CONSTRUCTION METHOD, NUCLEIC ACID MOLECULE, NUCLEIC ACID VECTOR, HOST CELL, COMPOSITION, MEDICAL DEVICE AND MANUFACTURING ARTICLE
US8415291B2 (en) 2008-10-31 2013-04-09 Centocor Ortho Biotech Inc. Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses
TWI496582B (en) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 Bispecific egfr/igfir binding molecules
US20110275535A1 (en) 2008-12-16 2011-11-10 Novartis Ag Yeast Display Systems
UY32341A (en) * 2008-12-19 2010-07-30 Glaxo Group Ltd NEW ANTIGEN UNION PROTEINS
EP2396000A1 (en) 2009-02-11 2011-12-21 Bristol-Myers Squibb Company Combination vegfr2 therapy with temozolomide
BRPI1008532B1 (en) 2009-02-12 2021-12-14 Janssen Biotech, Inc ISOLATED PROTEIN FRAMEWORK, METHOD FOR BUILDING AN ISOLATED PROTEIN FRAMEWORK LIBRARY, ISOLATED NUCLEIC ACID MOLECULE, ISOLATED NUCLEIC ACID VECTOR, BACTERIAL OR FUNGUS HOST CELL, COMPOSITION, MEDICAL DEVICE AND MANUFACTURING ARTICLE FOR PRODUCT USE IN HUMAN BEINGS
US8067201B2 (en) 2009-04-17 2011-11-29 Bristol-Myers Squibb Company Methods for protein refolding
US20120270797A1 (en) 2009-08-13 2012-10-25 Massachusetts Institute Of Technology Engineered proteins including mutant fibronectin domains
EP3434769B1 (en) 2009-10-30 2020-11-25 Novartis AG Universal fibronectin type iii bottom-side binding domain libraries
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
US20110123545A1 (en) 2009-11-24 2011-05-26 Bristol-Myers Squibb Company Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
WO2011100700A2 (en) 2010-02-12 2011-08-18 University Of Rochester Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies
BR112012019881A2 (en) 2010-02-18 2017-06-27 Bristol Myers Squibb Co fibronectin-based structural domain proteins that bind to il-23
KR20130056871A (en) * 2010-04-13 2013-05-30 브리스톨-마이어스 스큅 컴퍼니 Fibronectin based scaffold domain proteins that bind pcsk9
ES2755398T3 (en) 2010-04-13 2020-04-22 Medimmune Llc TRAIL R2 specific multimeric scaffolding
EP3103478B1 (en) 2010-04-30 2019-04-17 Janssen Biotech, Inc. Stabilized fibronectin domain compositions, methods and uses
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
JO3340B1 (en) 2010-05-26 2019-03-13 Regeneron Pharma Antibodies to human gdf8
ES2573108T3 (en) 2010-05-26 2016-06-06 Bristol-Myers Squibb Company Fibronectin-based framework proteins that have improved stability
CA2805862A1 (en) 2010-07-30 2012-02-02 Novartis Ag Fibronectin cradle molecules and libraries thereof
SG187867A1 (en) 2010-08-16 2013-03-28 Amgen Inc Antibodies that bind myostatin, compositions and methods
WO2012088006A1 (en) 2010-12-22 2012-06-28 Bristol-Myers Squibb Company Fibronectin based scaffold domain proteins that bind il-23
EP2697257B1 (en) 2011-04-13 2016-10-19 Bristol-Myers Squibb Company Fc fusion proteins comprising novel linkers or arrangements
EP2710382B1 (en) 2011-05-17 2017-10-18 Bristol-Myers Squibb Company Improved methods for the selection of binding proteins
US20140187488A1 (en) 2011-05-17 2014-07-03 Bristol-Myers Squibb Company Methods for maintaining pegylation of polypeptides
MX387605B (en) 2011-09-27 2025-03-18 Janssen Biotech Inc Fibronectin type iii repeat based protein scaffolds with alternative binding surfaces
JP2015525230A (en) 2012-06-11 2015-09-03 アムジエン・インコーポレーテツド Dual receptor antagonistic antigen binding protein and uses thereof
CN104487453B (en) 2012-06-15 2018-09-28 辉瑞公司 The antagonist antibodies and application thereof of improved anti-GDF-8
US8853154B2 (en) 2012-09-13 2014-10-07 Bristol-Myers Squibb Company Fibronectin based scaffold domain proteins that bind to myostatin
TWI897843B (en) 2017-05-03 2025-09-21 美商必治妥美雅史谷比公司 Stable formulations of fibronectin based scaffold domain proteins that bind to myostatin

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TW201416376A (en) 2014-05-01
PT2895503T (en) 2019-06-03
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HUE054699T2 (en) 2021-09-28
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CL2015000500A1 (en) 2015-07-31
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EA201590543A1 (en) 2015-06-30
ES2984405T3 (en) 2024-10-29
MX366666B (en) 2019-07-19
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US8993265B2 (en) 2015-03-31
LT3835310T (en) 2024-04-25
EP3835310A1 (en) 2021-06-16
EA033536B1 (en) 2019-10-31
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ZA201501457B (en) 2021-09-29
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US9493546B2 (en) 2016-11-15
US20240316161A1 (en) 2024-09-26
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US8933199B2 (en) 2015-01-13
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US20150072919A1 (en) 2015-03-12
SI2895503T1 (en) 2019-08-30
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UY35027A (en) 2014-03-31
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US20140105896A1 (en) 2014-04-17
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KR20150054938A (en) 2015-05-20
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US10245302B2 (en) 2019-04-02
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JP2018183138A (en) 2018-11-22
US10406212B2 (en) 2019-09-10
US20170088602A1 (en) 2017-03-30
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MY172863A (en) 2019-12-13
EP4397675A2 (en) 2024-07-10
IL270110A (en) 2019-12-31
US20190307855A1 (en) 2019-10-10
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