PL2673281T3 - Zawierające bor wielozasadowe inhibitory pomp usuwających substancje z komórek bakteryjnych oraz ich zastosowania terapeutyczne - Google Patents

Zawierające bor wielozasadowe inhibitory pomp usuwających substancje z komórek bakteryjnych oraz ich zastosowania terapeutyczne

Info

Publication number
PL2673281T3
PL2673281T3 PL12745348.8T PL12745348T PL2673281T3 PL 2673281 T3 PL2673281 T3 PL 2673281T3 PL 12745348 T PL12745348 T PL 12745348T PL 2673281 T3 PL2673281 T3 PL 2673281T3
Authority
PL
Poland
Prior art keywords
pump inhibitors
efflux pump
boron containing
bacterial efflux
containing polybasic
Prior art date
Application number
PL12745348.8T
Other languages
English (en)
Inventor
Tomasz Glinka
Robert Higuchi
Scott Hecker
Brian Eastman
Olga Rodny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2673281T3 publication Critical patent/PL2673281T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL12745348.8T 2011-02-07 2012-02-06 Zawierające bor wielozasadowe inhibitory pomp usuwających substancje z komórek bakteryjnych oraz ich zastosowania terapeutyczne PL2673281T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161440311P 2011-02-07 2011-02-07
US201161477129P 2011-04-19 2011-04-19

Publications (1)

Publication Number Publication Date
PL2673281T3 true PL2673281T3 (pl) 2016-10-31

Family

ID=46638916

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12745348.8T PL2673281T3 (pl) 2011-02-07 2012-02-06 Zawierające bor wielozasadowe inhibitory pomp usuwających substancje z komórek bakteryjnych oraz ich zastosowania terapeutyczne

Country Status (5)

Country Link
US (1) US8933018B2 (pl)
EP (1) EP2673281B1 (pl)
ES (1) ES2582471T3 (pl)
PL (1) PL2673281T3 (pl)
WO (1) WO2012109164A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014057072A1 (en) * 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
EP3086644A1 (en) * 2013-12-23 2016-11-02 Syngenta Participations AG Benzoxaborole fungicides
WO2015181387A1 (en) * 2014-05-30 2015-12-03 Universite Paris Descartes Cyclic compounds having a 1,3 diamino-functionality for use in the treatment of hiv infection
AU2015274427B2 (en) * 2014-06-13 2020-02-06 University Of Rochester Small molecule efflux pump inhibitors
KR20170024068A (ko) * 2014-07-01 2017-03-06 다이이찌 산쿄 가부시키가이샤 항박테리아제로서의 삼환식 벤즈옥사보롤
CN106467557B (zh) * 2015-08-18 2019-05-03 北京海美桐医药科技有限公司 他瓦硼罗的一种制备方法
KR102231489B1 (ko) 2016-05-12 2021-03-23 아나코르 파마슈티칼스 인코포레이티드 기생충 질병을 치료하기 위한 신규 화합물
US11795196B2 (en) * 2017-12-15 2023-10-24 Stealth Biotherapeutics Inc. Mitochondria-targeting peptides
CN111925302A (zh) * 2020-07-13 2020-11-13 菏泽润鑫生物科技有限公司 一种氰乙酰胺的合成方法
CN113151053B (zh) * 2021-03-15 2022-11-04 广东工业大学 一株佛里德兰德氏杆菌gdutan10及其应用
CN116554128A (zh) * 2023-05-08 2023-08-08 四川大学 一种自固化、高模高强的本征阻燃磺胺环氧树脂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US7879795B2 (en) 2004-05-21 2011-02-01 Mpex Pharmaceuticals, Inc. Enhancement of tigecycline potency using efflux pump inhibitors

Also Published As

Publication number Publication date
EP2673281B1 (en) 2016-04-13
WO2012109164A1 (en) 2012-08-16
EP2673281A1 (en) 2013-12-18
US20130316943A1 (en) 2013-11-28
EP2673281A4 (en) 2014-08-06
ES2582471T3 (es) 2016-09-13
US8933018B2 (en) 2015-01-13

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