PL266884A1 - Method of obtaining novel heterozepins - Google Patents
Method of obtaining novel heterozepinsInfo
- Publication number
- PL266884A1 PL266884A1 PL1987266884A PL26688487A PL266884A1 PL 266884 A1 PL266884 A1 PL 266884A1 PL 1987266884 A PL1987266884 A PL 1987266884A PL 26688487 A PL26688487 A PL 26688487A PL 266884 A1 PL266884 A1 PL 266884A1
- Authority
- PL
- Poland
- Prior art keywords
- heterozepins
- obtaining novel
- novel
- obtaining
- hetrazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Hetrazepines of the formula <IMAGE> in which A, Z, n, X, Y, R1, R2, R3 and R4 have the meaning mentioned in the description. The novel compounds are to be used for the treatment of pathological conditions and diseases in which PAF (platelet-activating factor) is involved.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3624647 | 1986-07-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
PL266884A1 true PL266884A1 (en) | 1988-09-15 |
PL153970B1 PL153970B1 (en) | 1991-06-28 |
Family
ID=6305650
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1987287349A PL157209B1 (en) | 1986-07-22 | 1987-07-20 | Method of obtaining novel substituted thiene(3,2-f) (1,2,4) triazol (4,3-a) (1,4) diazepins and thiene (3,2-f) imidazo(1,2-a) (1,4)azepins |
PL1987266884A PL153970B1 (en) | 1986-07-22 | 1987-07-20 | Process for manufacturing novel derivatives of thieno-/1,4/diazepins |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL1987287349A PL157209B1 (en) | 1986-07-22 | 1987-07-20 | Method of obtaining novel substituted thiene(3,2-f) (1,2,4) triazol (4,3-a) (1,4) diazepins and thiene (3,2-f) imidazo(1,2-a) (1,4)azepins |
Country Status (26)
Country | Link |
---|---|
US (1) | US5532233A (en) |
EP (1) | EP0254245B1 (en) |
JP (1) | JPH085895B2 (en) |
KR (1) | KR950013564B1 (en) |
AT (1) | ATE112280T1 (en) |
AU (1) | AU609408B2 (en) |
CA (1) | CA1338287C (en) |
CS (3) | CS277446B6 (en) |
CZ (1) | CZ284052B6 (en) |
DD (1) | DD281389A5 (en) |
DE (1) | DE3750599D1 (en) |
DK (1) | DK379787A (en) |
ES (1) | ES2061452T3 (en) |
FI (1) | FI873180A (en) |
HU (1) | HU203354B (en) |
IE (1) | IE65111B1 (en) |
IL (1) | IL83270A0 (en) |
MX (1) | MX7463A (en) |
NO (1) | NO166942C (en) |
NZ (1) | NZ221153A (en) |
PH (1) | PH30676A (en) |
PL (2) | PL157209B1 (en) |
PT (1) | PT85373B (en) |
SU (1) | SU1738089A3 (en) |
YU (1) | YU136187A (en) |
ZA (1) | ZA875333B (en) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60219955A (en) * | 1984-04-16 | 1985-11-02 | Matsushita Electric Works Ltd | Stepping motor |
ES2037013T3 (en) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | PROCEDURE FOR PREPARING TIENO-1,4-DIAZEPINES. |
US5895785A (en) * | 1987-10-20 | 1999-04-20 | Ruth Korth | Treatment and prevention of disorders mediated by LA-paf or endothelial cells |
US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
CA1324863C (en) * | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
DE3810848A1 (en) * | 1988-03-30 | 1989-10-19 | Boehringer Ingelheim Kg | NEW 2,3,4-SUBSTITUTED IMIDAZOLE AND 3,4,5-SUBSTITUTED 1,2,4-TRIAZOLE, THEIR PREPARATION AND USE |
CA1322367C (en) * | 1988-05-17 | 1993-09-21 | Yoshitomi Pharmaceutical Industries Ltd. | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
IL91386A0 (en) * | 1988-08-24 | 1990-04-29 | Boehringer Ingelheim Kg | Method for treating autoimmune diseases by using a paf antagonist and pharmaceutical compositions comprising it |
FI95708C (en) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogous process for preparing a 1,4-diazepine derivative and its pharmaceutically acceptable salt |
US5221671A (en) * | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5468740A (en) * | 1988-10-31 | 1995-11-21 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
RU2117670C1 (en) * | 1988-10-31 | 1998-08-20 | Эйсай Ко., Лтд. | Derivatives of triazolo[1,4]diazepine and methods of their synthesis |
US5382579A (en) * | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
US5304553A (en) * | 1988-10-31 | 1994-04-19 | Eisai Co., Ltd. | 1,4-diazepine derivative and its pharmaceutical use |
CA2010600A1 (en) * | 1989-02-23 | 1990-08-23 | Gojko Muacevic | Use of paf-antagonists for treating pathological changes in blood gas |
GB8907256D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors |
AT394562B (en) * | 1989-03-31 | 1992-05-11 | Scras | Process for the preparation of novel thienotriazolodiazepines |
GB8907257D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-paf and anti-ischemic agents |
GB8911030D0 (en) * | 1989-05-13 | 1989-06-28 | Scras | Hetrazepine derivatives |
GR1000393B (en) * | 1990-03-08 | 1992-06-30 | Sod Conseils Rech Applic | Preparation process of a novel sulfo-triazolo-diazepine |
NL9000627A (en) * | 1990-03-29 | 1991-10-16 | Scras | PROCESS FOR PREPARING NEW THIENOTRIAZOLO-DIAZEPINES. |
DE4010528A1 (en) * | 1990-04-02 | 1991-10-17 | Boehringer Ingelheim Kg | PRECARATIVE CHROMATOGRAPHIC SEPARATION METHOD FOR THE PRODUCTION OF ENANTIOMERALLY PURE HETRAZEPINE |
OA09202A (en) * | 1990-04-02 | 1992-06-30 | Sod Conseils Rech Applic | Process for the preparation of new thienotriazolo-diazepine derivatives. |
GR1000348B (en) * | 1990-04-27 | 1992-06-25 | Sod Conseils Rech Applic | Thieno-triazolo-diazepino-derivatives preparation method |
AT394563B (en) * | 1990-05-09 | 1992-05-11 | Scras | METHOD FOR PRODUCING THIENO-TRIAZOLODIAZEPINE DERIVATIVES |
DE4027470A1 (en) * | 1990-08-30 | 1992-03-05 | Boehringer Ingelheim Kg | NEW HETRAZEPINOIDE AMIDE |
DE4107521A1 (en) * | 1991-03-08 | 1992-09-10 | Boehringer Ingelheim Kg | NEW ACYLAMINOSUBSTITUTED HETRAZEPINE |
DE4128579A1 (en) * | 1991-08-28 | 1993-03-04 | Boehringer Ingelheim Kg | Use of thieno(3,2-f)(1,2,4) triazolo (4,3-a) (1,4) diazepine derivs. - for treatment and prevention of allergic rhinitis |
ATE221779T1 (en) * | 1991-11-04 | 2002-08-15 | Ruth-Maria Korth | TREATMENT AND PREVENTION OF ELEVATED LYSO-PAF LEVELS-MEDIATED MENTAL DISEASES USING PAF ANTAGONISTS |
WO1995032963A1 (en) * | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienylazole compound and thienotriazolodiazepine compound |
US5714262A (en) * | 1995-12-22 | 1998-02-03 | E. I. Du Pont De Nemours And Company | Production of poly(ethylene terephthalate) |
WO1998043638A1 (en) * | 1997-03-27 | 1998-10-08 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for autoimmune diseases |
AU742853B2 (en) * | 1997-07-31 | 2002-01-17 | Ube Industries, Ltd. | N-acylamino acid amide compounds and intermediates for preparation thereof |
US5939432A (en) | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
US6727258B2 (en) * | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
US20060165700A1 (en) * | 2002-09-04 | 2006-07-27 | Ostroff Gary R | Cancer therapy using whole glucan particles and antibodies |
CN102762575B (en) * | 2009-12-04 | 2015-04-15 | 桑诺维恩药品公司 | Multicyclic compounds and methods of use thereof |
CN116283877A (en) | 2016-07-29 | 2023-06-23 | 赛诺维信制药公司 | Compounds, compositions and uses thereof |
EA201990399A1 (en) | 2016-07-29 | 2019-07-31 | Суновион Фармасьютикалз, Инк. | COMPOUNDS, COMPOSITIONS AND THEIR APPLICATION |
US11129807B2 (en) | 2017-02-16 | 2021-09-28 | Sunovion Pharmaceuticals Inc. | Methods of treating schizophrenia |
EA202090414A1 (en) | 2017-08-02 | 2020-05-28 | Суновион Фармасьютикалз Инк. | COMPOUNDS AND THEIR APPLICATION |
CA3091292A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
AU2020236225A1 (en) | 2019-03-14 | 2021-09-16 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
EP4126869A1 (en) | 2020-03-31 | 2023-02-08 | F. Hoffmann-La Roche AG | Benzodiazepine derivatives as gaba a gamma1 pams |
MX2022012833A (en) | 2020-04-14 | 2022-11-07 | Sunovion Pharmaceuticals Inc | (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders. |
MX2023005678A (en) | 2020-11-16 | 2023-05-26 | Boehringer Ingelheim Int | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists. |
US20230190763A1 (en) | 2021-12-22 | 2023-06-22 | Boehringer Ingelheim International Gmbh | Cyclopentathiophene Carboxamide Derivatives as Platelet Activating Factor Receptor Antagonists |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES393101A1 (en) * | 1971-07-09 | 1974-05-16 | Made Labor Sa | Thieno-diazepin derivatives |
JPS5438116B2 (en) * | 1972-03-22 | 1979-11-19 | ||
JPS5116063B2 (en) * | 1972-05-30 | 1976-05-21 | ||
JPS5342400B2 (en) * | 1973-05-30 | 1978-11-10 | ||
US3902679A (en) * | 1974-01-07 | 1975-09-02 | Charles H Bost | Wire dispenser |
JPS50100096A (en) * | 1974-01-08 | 1975-08-08 | ||
JPS5747677B2 (en) * | 1974-03-01 | 1982-10-12 | ||
AT338799B (en) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS |
ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
DE3435973A1 (en) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | PHARMACEUTICAL COMPOSITIONS CONTAINING DIAZEPINE WITH PAF-ANTAGONISTIC EFFECT |
DE3502392A1 (en) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | NEW THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS |
ES2037013T3 (en) * | 1986-01-21 | 1993-06-16 | Boehringer Ingelheim Kg | PROCEDURE FOR PREPARING TIENO-1,4-DIAZEPINES. |
DE3610848A1 (en) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | NEW 1,4-DIAZEPINE |
DE3777541D1 (en) * | 1986-11-17 | 1992-04-23 | Yoshitomi Pharmaceutical | PAF ANTAGONISTIC THIENOTRIAZOLDIAZEPINE COMPOUNDS AND THEIR PHARMACEUTICAL APPLICATION. |
EP0315698B1 (en) * | 1987-05-28 | 1993-03-03 | Yoshitomi Pharmaceutical Industries, Ltd. | Thieno(triazolo)diazepine compounds and medicinal application of the same |
WO1988009792A1 (en) * | 1987-06-08 | 1988-12-15 | Yoshitomi Pharmaceutical Industries, Ltd. | Ester-substituted thienotriazolodiazepine compounds and their medicinal use |
DE3735525C2 (en) * | 1987-10-20 | 1997-02-20 | Korth Ruth Maria | Method for determining the efficacy of paf-acether receptor antagonists |
MC1999A1 (en) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | TRICYCLIC COMPOUNDS |
CA1324863C (en) * | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
EP0338993A1 (en) * | 1988-04-21 | 1989-10-25 | Sandoz Ag | 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines |
WO1989010143A1 (en) * | 1988-04-27 | 1989-11-02 | Schering Corporation | Certain paf antagonist antihistamine combinations and methods |
CA1322367C (en) * | 1988-05-17 | 1993-09-21 | Yoshitomi Pharmaceutical Industries Ltd. | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
FI95708C (en) * | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogous process for preparing a 1,4-diazepine derivative and its pharmaceutically acceptable salt |
GB8907256D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors |
-
1987
- 1987-07-10 PH PH35522A patent/PH30676A/en unknown
- 1987-07-18 AT AT87110443T patent/ATE112280T1/en not_active IP Right Cessation
- 1987-07-18 DE DE3750599T patent/DE3750599D1/en not_active Expired - Fee Related
- 1987-07-18 EP EP87110443A patent/EP0254245B1/en not_active Expired - Lifetime
- 1987-07-18 ES ES87110443T patent/ES2061452T3/en not_active Expired - Lifetime
- 1987-07-20 PL PL1987287349A patent/PL157209B1/en unknown
- 1987-07-20 YU YU01361/87A patent/YU136187A/en unknown
- 1987-07-20 PL PL1987266884A patent/PL153970B1/en unknown
- 1987-07-20 FI FI873180A patent/FI873180A/en not_active Application Discontinuation
- 1987-07-21 ZA ZA875333A patent/ZA875333B/en unknown
- 1987-07-21 IL IL83270A patent/IL83270A0/en not_active IP Right Cessation
- 1987-07-21 HU HU873355A patent/HU203354B/en not_active IP Right Cessation
- 1987-07-21 JP JP62182121A patent/JPH085895B2/en not_active Expired - Lifetime
- 1987-07-21 DD DD87305190A patent/DD281389A5/en not_active IP Right Cessation
- 1987-07-21 DK DK379787A patent/DK379787A/en not_active Application Discontinuation
- 1987-07-21 NO NO873041A patent/NO166942C/en not_active IP Right Cessation
- 1987-07-21 CS CS891931A patent/CS277446B6/en not_active IP Right Cessation
- 1987-07-21 CS CS891930A patent/CS277445B6/en not_active IP Right Cessation
- 1987-07-21 PT PT85373A patent/PT85373B/en not_active IP Right Cessation
- 1987-07-21 CS CS550887A patent/CS274456B2/en not_active IP Right Cessation
- 1987-07-22 KR KR87007939A patent/KR950013564B1/en not_active IP Right Cessation
- 1987-07-22 NZ NZ221153A patent/NZ221153A/en unknown
- 1987-07-22 AU AU76015/87A patent/AU609408B2/en not_active Ceased
- 1987-07-22 CA CA000542748A patent/CA1338287C/en not_active Expired - Fee Related
- 1987-07-22 MX MX746387A patent/MX7463A/en unknown
- 1987-07-22 IE IE198387A patent/IE65111B1/en not_active IP Right Cessation
-
1989
- 1989-04-10 CZ CS892206A patent/CZ284052B6/en unknown
- 1989-08-17 SU SU894614791A patent/SU1738089A3/en active
-
1994
- 1994-09-08 US US08/302,578 patent/US5532233A/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL266884A1 (en) | Method of obtaining novel heterozepins | |
ATE45942T1 (en) | DIARYLACETYLENES, THEIR PRODUCTION AND USE. | |
AU4083589A (en) | ((1-lower alkyloxy-1-methyl)ethoxy)amines | |
GR3005470T3 (en) | ||
HUT40638A (en) | Process for producing 1,2-dithiolane-3-pentanoic acid | |
IE851623L (en) | Substituted benzamides | |
EP0280946A3 (en) | Organosilanes containing benzoylthiourea; process for their preparation | |
PT83309A (en) | NEW PYRROLO-BENZIMIDAZOLE PYRROLO-BENZOXAZOLE AND PYRROLO-BENZTHIAZOLE METHOD FOR THE PRODUCTION THEREOF AND THESE COMPOUNDS CONTAINING SUBSTANCES | |
SE8203580L (en) | SET TO MAKE APOVINCAMIC ACID ESTERS | |
DE2960324D1 (en) | 4,5-methano-bufadienolide-rhamnosides, process for their preparation and medicines containing them | |
PL248044A1 (en) | Process for preparing esters of 1,1-dioxide of 6-aminomethyl/-penicillanic acid and their intermediate compounds | |
SE8801798D0 (en) | CHEMICAL INTERMEDIATES AND PROCESS | |
DK147382A (en) | METHOD FOR PREPARING 5,6-DIHYDRO-11-ALKYLENE MORPHANTRIDIN-6-ONER | |
IL63456A0 (en) | Alpha-substituted ureidobenzylpenicillanic acid and process for producing the same | |
IL69416A0 (en) | Process for inverting the configuration of optically active compounds,and optically active intermediates produced in the process | |
CS275481B2 (en) | New n-hydroxytriazole derivatives, method of their production and fungicides containing them in active substance | |
FR2359808A1 (en) | PHYTOL PREPARATION PROCESS | |
FI842639A (en) | ACYLDERIVAT AV 1,4,3,6-DIANHYDRO-HEXITOL. | |
PL258077A3 (en) | Method of obtaining novel heterocyclic compounds |