PL2601196T3 - N-demetylowanie 6-ketomorfinanów - Google Patents

N-demetylowanie 6-ketomorfinanów

Info

Publication number
PL2601196T3
PL2601196T3 PL11746372T PL11746372T PL2601196T3 PL 2601196 T3 PL2601196 T3 PL 2601196T3 PL 11746372 T PL11746372 T PL 11746372T PL 11746372 T PL11746372 T PL 11746372T PL 2601196 T3 PL2601196 T3 PL 2601196T3
Authority
PL
Poland
Prior art keywords
demethylation
morphinans
keto
keto morphinans
Prior art date
Application number
PL11746372T
Other languages
English (en)
Inventor
Peter X Wang
Tao Jiang
David W Berberich
Subo Liao
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2601196T3 publication Critical patent/PL2601196T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL11746372T 2010-08-04 2011-08-03 N-demetylowanie 6-ketomorfinanów PL2601196T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37065310P 2010-08-04 2010-08-04
PCT/US2011/046345 WO2012018872A1 (en) 2010-08-04 2011-08-03 N-demethylation of 6-keto morphinans
EP11746372.9A EP2601196B1 (en) 2010-08-04 2011-08-03 N-demethylation of 6-keto morphinans

Publications (1)

Publication Number Publication Date
PL2601196T3 true PL2601196T3 (pl) 2014-09-30

Family

ID=44513172

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11746372T PL2601196T3 (pl) 2010-08-04 2011-08-03 N-demetylowanie 6-ketomorfinanów

Country Status (8)

Country Link
US (1) US8624030B2 (pl)
EP (1) EP2601196B1 (pl)
JP (2) JP2013532731A (pl)
AU (1) AU2011285840B2 (pl)
CA (1) CA2806596A1 (pl)
ES (1) ES2470315T3 (pl)
PL (1) PL2601196T3 (pl)
WO (1) WO2012018872A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011068594A1 (en) 2009-12-04 2011-06-09 Alkermes, Inc. Morphinan derivatives for the treatment of drug overdose
PL2601196T3 (pl) * 2010-08-04 2014-09-30 Mallinckrodt Llc N-demetylowanie 6-ketomorfinanów
PL2601195T3 (pl) * 2010-08-04 2014-10-31 Mallinckrodt Llc Tandemowy sposób wytwarzania n-alkilomorfinanów
TR201900097T4 (tr) 2010-08-23 2019-02-21 Alkermes Pharma Ireland Ltd Anti̇psi̇koti̇k i̇le i̇ndüklenen ki̇lo artişini tedavi̇ etmeye yöneli̇k yöntemler.
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
CA2913558C (en) 2013-05-24 2021-06-29 Rhodes Technologies Opioid ketal compounds and uses thereof
WO2015074049A1 (en) * 2013-11-18 2015-05-21 Mallinckrodt Llc Preparation of normorphinans
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
AU2008338971B2 (en) * 2007-12-17 2013-08-29 SpecGx LLC Processes for the preparation of normorphinan salts
US7671204B2 (en) * 2007-12-17 2010-03-02 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
PL2601196T3 (pl) * 2010-08-04 2014-09-30 Mallinckrodt Llc N-demetylowanie 6-ketomorfinanów

Also Published As

Publication number Publication date
JP2015193658A (ja) 2015-11-05
US8624030B2 (en) 2014-01-07
US20120035366A1 (en) 2012-02-09
AU2011285840B2 (en) 2014-07-10
CA2806596A1 (en) 2012-02-09
WO2012018872A1 (en) 2012-02-09
AU2011285840A1 (en) 2013-03-21
EP2601196A1 (en) 2013-06-12
ES2470315T3 (es) 2014-06-23
JP2013532731A (ja) 2013-08-19
EP2601196B1 (en) 2014-04-30

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