PL2558435T3 - Krystaliczny rombowy mebutynian ingenolu - Google Patents
Krystaliczny rombowy mebutynian ingenoluInfo
- Publication number
- PL2558435T3 PL2558435T3 PL11731076T PL11731076T PL2558435T3 PL 2558435 T3 PL2558435 T3 PL 2558435T3 PL 11731076 T PL11731076 T PL 11731076T PL 11731076 T PL11731076 T PL 11731076T PL 2558435 T3 PL2558435 T3 PL 2558435T3
- Authority
- PL
- Poland
- Prior art keywords
- ingenol mebutate
- crystalline orthorhombic
- orthorhombic
- crystalline
- mebutate
- Prior art date
Links
- VDJHFHXMUKFKET-UHFFFAOYSA-N Ingenol mebutate Natural products CC1CC2C(C)(C)C2C2C=C(CO)C(O)C3(O)C(OC(=O)C(C)=CC)C(C)=CC31C2=O VDJHFHXMUKFKET-UHFFFAOYSA-N 0.000 title 1
- VDJHFHXMUKFKET-WDUFCVPESA-N ingenol mebutate Chemical compound C[C@@H]1C[C@H]2C(C)(C)[C@H]2[C@@H]2C=C(CO)[C@@H](O)[C@]3(O)[C@@H](OC(=O)C(\C)=C/C)C(C)=C[C@]31C2=O VDJHFHXMUKFKET-WDUFCVPESA-N 0.000 title 1
- 229960002993 ingenol mebutate Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/86—Ring systems containing bridged rings containing four rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Liquid Crystal Substances (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32503210P | 2010-04-16 | 2010-04-16 | |
| PCT/IB2011/001277 WO2011128780A1 (en) | 2010-04-16 | 2011-04-18 | Crystalline ingenol mebutate |
| EP11731076.3A EP2558435B1 (en) | 2010-04-16 | 2011-04-18 | Orthorhombic crystalline ingenol mebutate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2558435T3 true PL2558435T3 (pl) | 2017-10-31 |
Family
ID=44318125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11731076T PL2558435T3 (pl) | 2010-04-16 | 2011-04-18 | Krystaliczny rombowy mebutynian ingenolu |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8653133B2 (pl) |
| EP (1) | EP2558435B1 (pl) |
| JP (1) | JP2013525300A (pl) |
| KR (1) | KR20130091647A (pl) |
| CN (1) | CN102844294A (pl) |
| AU (1) | AU2011241893B2 (pl) |
| BR (1) | BR112012026420A2 (pl) |
| CA (1) | CA2796044A1 (pl) |
| CY (1) | CY1119394T1 (pl) |
| DK (1) | DK2558435T3 (pl) |
| ES (1) | ES2633814T3 (pl) |
| HR (1) | HRP20171072T1 (pl) |
| HU (1) | HUE034138T2 (pl) |
| IL (1) | IL222265A (pl) |
| LT (1) | LT2558435T (pl) |
| MX (1) | MX338480B (pl) |
| NZ (1) | NZ603567A (pl) |
| PL (1) | PL2558435T3 (pl) |
| PT (1) | PT2558435T (pl) |
| RS (1) | RS56337B1 (pl) |
| RU (1) | RU2572618C2 (pl) |
| SI (1) | SI2558435T1 (pl) |
| SM (1) | SMT201700350T1 (pl) |
| WO (1) | WO2011128780A1 (pl) |
| ZA (1) | ZA201207409B (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2395993T3 (en) * | 2009-02-13 | 2017-08-07 | Leo Laboratories Ltd | SKIN TREATMENT |
| PL2558435T3 (pl) | 2010-04-16 | 2017-10-31 | Leo Pharma As | Krystaliczny rombowy mebutynian ingenolu |
| DK2595948T3 (da) * | 2010-07-20 | 2019-10-21 | Leo Laboratories Ltd | Fremgangsmåde til fremstilling af ingenol-3-angelat |
| US9402823B2 (en) | 2010-12-17 | 2016-08-02 | Leo Laboratories Limited | Ingenols for treating seborrheic keratosis |
| WO2012176015A1 (en) * | 2011-06-24 | 2012-12-27 | Leo Pharma A/S | Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate |
| WO2013088380A1 (en) | 2011-12-12 | 2013-06-20 | Leo Laboratories Limited | Gel compositions |
| EP2790672A1 (en) * | 2011-12-12 | 2014-10-22 | Leo Laboratories Limited | Gel compositions |
| EP2790694A1 (en) * | 2011-12-12 | 2014-10-22 | Leo Laboratories Limited | A topical composition comprising an ingenol derivative and a surfactant-cosolvent mixture |
| EP2806869A1 (en) * | 2012-01-26 | 2014-12-03 | Leo Pharma A/S | Ingenol mebutate in combination with cryotherapy for the treatment of actinic keratosis |
| US20130251782A1 (en) * | 2012-03-22 | 2013-09-26 | Leo Laboratories Limited | Topical application of ingenol mebutate with occlusion |
| EP2858629A1 (en) * | 2012-06-08 | 2015-04-15 | Leo Laboratories Limited | A topical gel composition comprising an ingenol derivative and a solvent mixture |
| GB201222405D0 (en) * | 2012-12-12 | 2013-01-23 | Leo Lab Ltd | Gel compositions |
| WO2014090859A1 (en) * | 2012-12-12 | 2014-06-19 | Leo Laboratories Limited | Gel compositions |
| GB201222403D0 (en) * | 2012-12-12 | 2013-01-23 | Leo Lab Ltd | Gel compositions |
| GB201222406D0 (en) * | 2012-12-12 | 2013-01-23 | Leo Lab Ltd | Gel compositions |
| US9526714B2 (en) * | 2014-03-24 | 2016-12-27 | Leo Laboratories Limited | Method for treating skin lesions with ingenol mebutate |
| AU2014100280B4 (en) * | 2014-03-24 | 2015-01-15 | Leo Pharma A/S | A method of treating skin lesions |
| CN107510651A (zh) * | 2016-06-17 | 2017-12-26 | 王成 | 一种小分子免疫药物的纳米靶向制剂制备及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO864097A0 (en) | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
| CA2569003A1 (en) * | 2004-05-07 | 2005-12-08 | Massachusetts Institute Of Technology | Methods and compositions for cancer treatment relating to brca1 brct domain recognition of phosphorylated bach1 |
| RU2438689C9 (ru) * | 2005-06-28 | 2012-03-10 | Амазония Фитомедикаментус ЛТДА | Активная фракция экстракта млечного сока растения семейства euphorbiaceae, способ ее получения, композиция на ее основе (варианты) и способ лечения заболеваний, связанных с пролиферацией клеток (варианты) |
| JP2009516651A (ja) * | 2005-11-14 | 2009-04-23 | ペプリン リサーチ プロプライエタリー リミティッド | 癌を治療するための他の薬剤と組み合わせたアンゲロイル置換インゲナンの使用 |
| WO2007059584A1 (en) | 2005-11-25 | 2007-05-31 | Peplin Research Pty Ltd | Methods for wound healing |
| GB0525680D0 (en) | 2005-12-16 | 2006-01-25 | Peplin Ltd | Therapeutic compositions |
| SI2152261T1 (sl) * | 2007-04-30 | 2016-05-31 | Leo Laboratories Limited | Zdravljenje viralno induciranih lezij |
| PL2558435T3 (pl) | 2010-04-16 | 2017-10-31 | Leo Pharma As | Krystaliczny rombowy mebutynian ingenolu |
-
2011
- 2011-04-18 PL PL11731076T patent/PL2558435T3/pl unknown
- 2011-04-18 EP EP11731076.3A patent/EP2558435B1/en not_active Revoked
- 2011-04-18 AU AU2011241893A patent/AU2011241893B2/en not_active Ceased
- 2011-04-18 RU RU2012148720/04A patent/RU2572618C2/ru active
- 2011-04-18 HR HRP20171072TT patent/HRP20171072T1/hr unknown
- 2011-04-18 SM SM20170350T patent/SMT201700350T1/it unknown
- 2011-04-18 PT PT117310763T patent/PT2558435T/pt unknown
- 2011-04-18 WO PCT/IB2011/001277 patent/WO2011128780A1/en not_active Ceased
- 2011-04-18 DK DK11731076.3T patent/DK2558435T3/en active
- 2011-04-18 CN CN2011800193189A patent/CN102844294A/zh active Pending
- 2011-04-18 KR KR1020127029898A patent/KR20130091647A/ko not_active Ceased
- 2011-04-18 SI SI201131237T patent/SI2558435T1/sl unknown
- 2011-04-18 ES ES11731076.3T patent/ES2633814T3/es active Active
- 2011-04-18 US US13/088,910 patent/US8653133B2/en not_active Expired - Fee Related
- 2011-04-18 RS RS20170728A patent/RS56337B1/sr unknown
- 2011-04-18 LT LTEP11731076.3T patent/LT2558435T/lt unknown
- 2011-04-18 MX MX2012011844A patent/MX338480B/es active IP Right Grant
- 2011-04-18 NZ NZ603567A patent/NZ603567A/xx not_active IP Right Cessation
- 2011-04-18 BR BR112012026420A patent/BR112012026420A2/pt not_active Application Discontinuation
- 2011-04-18 CA CA2796044A patent/CA2796044A1/en not_active Abandoned
- 2011-04-18 HU HUE11731076A patent/HUE034138T2/en unknown
- 2011-04-18 JP JP2013504356A patent/JP2013525300A/ja active Pending
-
2012
- 2012-10-03 ZA ZA2012/07409A patent/ZA201207409B/en unknown
- 2012-10-09 IL IL222265A patent/IL222265A/en active IP Right Grant
-
2014
- 2014-02-17 US US14/182,274 patent/US9440906B2/en not_active Expired - Fee Related
-
2017
- 2017-07-18 CY CY20171100767T patent/CY1119394T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2633814T3 (es) | 2017-09-25 |
| US20110257262A1 (en) | 2011-10-20 |
| NZ603567A (en) | 2013-10-25 |
| JP2013525300A (ja) | 2013-06-20 |
| CN102844294A (zh) | 2012-12-26 |
| RS56337B1 (sr) | 2017-12-29 |
| EP2558435A1 (en) | 2013-02-20 |
| HRP20171072T1 (hr) | 2017-10-06 |
| US20150025265A1 (en) | 2015-01-22 |
| BR112012026420A2 (pt) | 2016-08-02 |
| DK2558435T3 (en) | 2017-08-14 |
| IL222265A (en) | 2015-04-30 |
| AU2011241893A1 (en) | 2012-12-06 |
| SMT201700350T1 (it) | 2017-09-07 |
| HUE034138T2 (en) | 2018-01-29 |
| CY1119394T1 (el) | 2018-02-14 |
| WO2011128780A1 (en) | 2011-10-20 |
| CA2796044A1 (en) | 2011-10-20 |
| SI2558435T1 (sl) | 2017-10-30 |
| MX338480B (es) | 2016-04-19 |
| US9440906B2 (en) | 2016-09-13 |
| RU2572618C2 (ru) | 2016-01-20 |
| KR20130091647A (ko) | 2013-08-19 |
| LT2558435T (lt) | 2017-07-25 |
| AU2011241893B2 (en) | 2014-11-06 |
| EP2558435B1 (en) | 2017-06-07 |
| ZA201207409B (en) | 2014-06-25 |
| IL222265A0 (en) | 2012-12-31 |
| RU2012148720A (ru) | 2014-05-27 |
| US8653133B2 (en) | 2014-02-18 |
| MX2012011844A (es) | 2012-11-30 |
| PT2558435T (pt) | 2017-07-24 |
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