PL2297100T3 - Tetrahydrocyklopenta[B]indolowe modulatory receptora androgenowego - Google Patents
Tetrahydrocyklopenta[B]indolowe modulatory receptora androgenowegoInfo
- Publication number
- PL2297100T3 PL2297100T3 PL09747531T PL09747531T PL2297100T3 PL 2297100 T3 PL2297100 T3 PL 2297100T3 PL 09747531 T PL09747531 T PL 09747531T PL 09747531 T PL09747531 T PL 09747531T PL 2297100 T3 PL2297100 T3 PL 2297100T3
- Authority
- PL
- Poland
- Prior art keywords
- tetrahydrocyclopenta
- indole
- androgen receptor
- receptor modulators
- modulators
- Prior art date
Links
- IAZKTAKWBHQCGF-UHFFFAOYSA-N 1,2,3,3a-tetrahydrocyclopenta[b]indole Chemical compound N1=C2C=CC=CC2=C2C1CCC2 IAZKTAKWBHQCGF-UHFFFAOYSA-N 0.000 title 1
- 239000000849 selective androgen receptor modulator Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5372208P | 2008-05-16 | 2008-05-16 | |
| PCT/US2009/043875 WO2009140448A1 (en) | 2008-05-16 | 2009-05-14 | Tetrahydrocyclopenta[b]indole androgen receptor modulators |
| EP09747531A EP2297100B1 (en) | 2008-05-16 | 2009-05-14 | Tetrahydrocyclopenta[b]indole androgen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2297100T3 true PL2297100T3 (pl) | 2013-03-29 |
Family
ID=40847864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09747531T PL2297100T3 (pl) | 2008-05-16 | 2009-05-14 | Tetrahydrocyklopenta[B]indolowe modulatory receptora androgenowego |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8486943B2 (enExample) |
| EP (1) | EP2297100B1 (enExample) |
| JP (1) | JP5603327B2 (enExample) |
| KR (1) | KR101278788B1 (enExample) |
| CN (1) | CN102026974B (enExample) |
| AU (1) | AU2009246348B2 (enExample) |
| BR (1) | BRPI0912394A2 (enExample) |
| CA (1) | CA2724629C (enExample) |
| CY (1) | CY1113341T1 (enExample) |
| DK (1) | DK2297100T3 (enExample) |
| EA (1) | EA019713B1 (enExample) |
| ES (1) | ES2396612T3 (enExample) |
| HR (1) | HRP20120917T1 (enExample) |
| MX (1) | MX2010012436A (enExample) |
| PL (1) | PL2297100T3 (enExample) |
| PT (1) | PT2297100E (enExample) |
| SI (1) | SI2297100T1 (enExample) |
| WO (1) | WO2009140448A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA98777C2 (en) | 2006-11-20 | 2012-06-25 | Эли Лилли Энд Компани | Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators |
| US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
| EP2531029B1 (en) | 2010-02-04 | 2016-10-19 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2011143469A1 (en) | 2010-05-12 | 2011-11-17 | Radius Health,Inc | Therapeutic regimens |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| FI3834824T3 (fi) | 2014-03-28 | 2025-12-05 | Univ Duke | Estrogeenireseptoripositiivisen rintasyövän hoito selektiivisellä estrogeenireseptorin modulaattorilla |
| JOP20180072A1 (ar) * | 2014-09-11 | 2019-01-30 | Lilly Co Eli | علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين |
| JP7221699B2 (ja) | 2016-06-22 | 2023-02-14 | エリプセス ファーマ エルティーディー | Ａｒ＋乳癌の治療方法 |
| US20180185347A1 (en) * | 2016-11-16 | 2018-07-05 | Transition Therapeutics (Ireland 2) Limited | Tetrahydrocyclopenta[b]indole compounds and phosphodiesterase inhibitors for the treatment of the signs and symptoms of bhp |
| KR102881465B1 (ko) | 2017-01-05 | 2025-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| KR20210127961A (ko) | 2019-02-12 | 2021-10-25 | 래디어스 파마슈티컬스, 인코포레이티드 | 방법 및 화합물 |
| US20230096602A1 (en) * | 2020-01-27 | 2023-03-30 | Eirgen Pharma Ltd. | Tetrahydrocyclopenta[b]indole compounds for treatment of renal disease |
| CN116761598A (zh) * | 2020-07-06 | 2023-09-15 | 新月生物科学 | Fabp4调节化合物的抗病毒用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988820A (en) | 1986-02-21 | 1991-01-29 | Bayer Aktiengesellschaft | Cycloalkano(1,2-B) indole-sulponamides |
| GB8924392D0 (en) | 1989-10-30 | 1989-12-20 | Bayer Ag | Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides |
| GB9008108D0 (en) | 1990-04-10 | 1990-06-06 | Bayer Ag | Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles |
| DE4027278A1 (de) | 1990-08-29 | 1992-03-05 | Bayer Ag | Heterocyclisch substituierte indolsulfonamide |
| DE4131346A1 (de) | 1991-09-20 | 1993-03-25 | Bayer Ag | Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JP2005527464A (ja) | 2001-08-09 | 2005-09-15 | イーライ・リリー・アンド・カンパニー | ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体 |
| DE10164564B4 (de) | 2001-12-14 | 2007-05-16 | Zentaris Gmbh | Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR) |
| US7534897B2 (en) | 2002-05-16 | 2009-05-19 | Shionogi & Co., Ltd. | Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism |
| US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
| US7019022B2 (en) | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| ES2414604T3 (es) | 2004-03-03 | 2013-07-22 | Eli Lilly And Company | Moduladores del receptor nuclear de hormonas esteroides de derivados bicíclicos sustituidos con indol |
| US8946444B2 (en) | 2004-11-23 | 2015-02-03 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control |
| AR052674A1 (es) | 2005-02-17 | 2007-03-28 | Wyeth Corp | Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados |
| MX2007015905A (es) * | 2005-06-24 | 2008-03-06 | Lilly Co Eli | Derivados de tetrahidrocarbazol utiles como moduladores de receptor de androgeno (sarm). |
| WO2007047604A2 (en) | 2005-10-18 | 2007-04-26 | Elixir Pharmaceuticals, Inc. | Sirt1 inhibition |
| WO2008019825A1 (en) | 2006-08-14 | 2008-02-21 | Santhera Pharmaceuticals (Schweiz) Ag | Use of tricyclic indole derivatives for the treatment of muscular diseases |
| UA98777C2 (en) * | 2006-11-20 | 2012-06-25 | Эли Лилли Энд Компани | Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators |
-
2009
- 2009-05-14 BR BRPI0912394A patent/BRPI0912394A2/pt not_active IP Right Cessation
- 2009-05-14 JP JP2011509679A patent/JP5603327B2/ja active Active
- 2009-05-14 DK DK09747531.3T patent/DK2297100T3/da active
- 2009-05-14 EP EP09747531A patent/EP2297100B1/en active Active
- 2009-05-14 HR HRP20120917AT patent/HRP20120917T1/hr unknown
- 2009-05-14 PL PL09747531T patent/PL2297100T3/pl unknown
- 2009-05-14 PT PT97475313T patent/PT2297100E/pt unknown
- 2009-05-14 ES ES09747531T patent/ES2396612T3/es active Active
- 2009-05-14 EA EA201071317A patent/EA019713B1/ru not_active IP Right Cessation
- 2009-05-14 CA CA2724629A patent/CA2724629C/en not_active Expired - Fee Related
- 2009-05-14 AU AU2009246348A patent/AU2009246348B2/en not_active Ceased
- 2009-05-14 WO PCT/US2009/043875 patent/WO2009140448A1/en not_active Ceased
- 2009-05-14 KR KR1020107025588A patent/KR101278788B1/ko not_active Expired - Fee Related
- 2009-05-14 US US12/989,959 patent/US8486943B2/en active Active
- 2009-05-14 CN CN200980117076XA patent/CN102026974B/zh active Active
- 2009-05-14 MX MX2010012436A patent/MX2010012436A/es active IP Right Grant
- 2009-05-14 SI SI200930447T patent/SI2297100T1/sl unknown
-
2012
- 2012-11-14 CY CY20121101095T patent/CY1113341T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100132551A (ko) | 2010-12-17 |
| US8486943B2 (en) | 2013-07-16 |
| EA201071317A1 (ru) | 2011-06-30 |
| CN102026974B (zh) | 2013-08-28 |
| AU2009246348B2 (en) | 2012-04-12 |
| DK2297100T3 (da) | 2012-12-17 |
| JP5603327B2 (ja) | 2014-10-08 |
| ES2396612T3 (es) | 2013-02-22 |
| CN102026974A (zh) | 2011-04-20 |
| WO2009140448A1 (en) | 2009-11-19 |
| CA2724629C (en) | 2014-08-19 |
| MX2010012436A (es) | 2010-12-06 |
| KR101278788B1 (ko) | 2013-06-25 |
| AU2009246348A8 (en) | 2010-12-16 |
| WO2009140448A8 (en) | 2010-01-07 |
| CA2724629A1 (en) | 2009-11-19 |
| SI2297100T1 (sl) | 2013-02-28 |
| CY1113341T1 (el) | 2016-06-22 |
| EP2297100B1 (en) | 2012-10-31 |
| HRP20120917T1 (hr) | 2012-12-31 |
| JP2011520903A (ja) | 2011-07-21 |
| AU2009246348A1 (en) | 2009-11-19 |
| EA019713B1 (ru) | 2014-05-30 |
| BRPI0912394A2 (pt) | 2016-07-26 |
| US20110039855A1 (en) | 2011-02-17 |
| EP2297100A1 (en) | 2011-03-23 |
| PT2297100E (pt) | 2013-01-24 |
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