PL2155683T3 - Pochodne pirydonu jako inhibitory p38α MAPK - Google Patents
Pochodne pirydonu jako inhibitory p38α MAPKInfo
- Publication number
- PL2155683T3 PL2155683T3 PL08752572T PL08752572T PL2155683T3 PL 2155683 T3 PL2155683 T3 PL 2155683T3 PL 08752572 T PL08752572 T PL 08752572T PL 08752572 T PL08752572 T PL 08752572T PL 2155683 T3 PL2155683 T3 PL 2155683T3
- Authority
- PL
- Poland
- Prior art keywords
- mapk inhibitors
- pyridone derivatives
- pyridone
- derivatives
- mapk
- Prior art date
Links
- 101100291385 Drosophila melanogaster p38a gene Proteins 0.000 title 1
- 101150024075 Mapk1 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91584507P | 2007-05-03 | 2007-05-03 | |
| EP08752572A EP2155683B8 (en) | 2007-05-03 | 2008-05-02 | Pyridone derivatives as p38a mapk inhibitors |
| PCT/JP2008/058689 WO2008140066A2 (en) | 2007-05-03 | 2008-05-02 | Pyridone derivatives as p38a mapk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2155683T3 true PL2155683T3 (pl) | 2011-08-31 |
Family
ID=39865639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08752572T PL2155683T3 (pl) | 2007-05-03 | 2008-05-02 | Pochodne pirydonu jako inhibitory p38α MAPK |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8173684B2 (pl) |
| EP (1) | EP2155683B8 (pl) |
| JP (1) | JP2010526026A (pl) |
| KR (1) | KR20100016563A (pl) |
| CN (1) | CN101675034A (pl) |
| AR (1) | AR066421A1 (pl) |
| AT (1) | ATE502013T1 (pl) |
| CA (1) | CA2686091A1 (pl) |
| DE (1) | DE602008005581D1 (pl) |
| ES (1) | ES2363109T3 (pl) |
| MX (1) | MX2009011769A (pl) |
| PL (1) | PL2155683T3 (pl) |
| PT (1) | PT2155683E (pl) |
| TW (1) | TW200904421A (pl) |
| WO (1) | WO2008140066A2 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5627574B2 (ja) | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| PL2589592T3 (pl) | 2010-06-30 | 2019-03-29 | Fujifilm Corporation | Nowe pochodne nikotynamidu lub ich sole |
| CN103221395A (zh) * | 2010-11-23 | 2013-07-24 | 先正达参股股份有限公司 | 杀虫化合物 |
| RU2576623C2 (ru) | 2011-12-28 | 2016-03-10 | Фуджифилм Корпорэйшн | Новое производное никотинамида или его соль |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| CN104961803B (zh) * | 2015-07-08 | 2017-11-28 | 中国人民解放军军事医学科学院基础医学研究所 | 一种治疗心肌缺血再灌注损伤的多肽药物 |
| CN104961804B (zh) * | 2015-07-08 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | p38α拮抗肽突变体及其应用 |
| EP3474835B1 (en) * | 2016-06-23 | 2023-07-05 | University of Maryland, Baltimore | Non-catalytic substrate-selective p38 -specific mapk inhibitors with endothelial-stabilizing and anti-inflammatory activity, and methods of use thereof |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN107033134B (zh) * | 2017-05-03 | 2020-02-21 | 贵州大学 | 含吡啶盐和1,3,4-噁二唑基的双酰胺类化合物及其制备方法及应用 |
| CA3122371A1 (en) | 2018-12-07 | 2020-06-11 | University Of Maryland, Baltimore | Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors |
| WO2021064186A1 (en) * | 2019-10-04 | 2021-04-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain |
| US11286260B2 (en) | 2020-05-18 | 2022-03-29 | Gen1E Lifesciences Inc. | P38α mitogen-activated protein kinase inhibitors |
| AU2021370893B2 (en) | 2020-10-29 | 2024-03-07 | Gen1E Lifesciences Inc. | Crystalline 5-(dimethylamino) -n- (4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate |
| IL306101A (en) | 2021-03-23 | 2023-11-01 | Gen1E Lifesciences Inc | Naphthyl-mutated p38 alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| ATE542817T1 (de) | 2004-11-10 | 2012-02-15 | Ono Pharmaceutical Co | Stickstoffhaltige heterocyclische verbindung und deren pharmazeutische verwendung |
| RS53599B1 (sr) | 2005-05-10 | 2015-02-27 | Intermune, Inc. | Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza |
| US20090042856A1 (en) | 2005-09-01 | 2009-02-12 | Astellas Pharma Inc | Pyridazinone derivatives used for the treatment of pain |
-
2008
- 2008-04-30 TW TW097115812A patent/TW200904421A/zh unknown
- 2008-05-02 PT PT08752572T patent/PT2155683E/pt unknown
- 2008-05-02 MX MX2009011769A patent/MX2009011769A/es active IP Right Grant
- 2008-05-02 ES ES08752572T patent/ES2363109T3/es active Active
- 2008-05-02 WO PCT/JP2008/058689 patent/WO2008140066A2/en not_active Ceased
- 2008-05-02 CN CN200880014625A patent/CN101675034A/zh active Pending
- 2008-05-02 EP EP08752572A patent/EP2155683B8/en not_active Not-in-force
- 2008-05-02 DE DE602008005581T patent/DE602008005581D1/de active Active
- 2008-05-02 KR KR1020097023816A patent/KR20100016563A/ko not_active Withdrawn
- 2008-05-02 CA CA002686091A patent/CA2686091A1/en not_active Abandoned
- 2008-05-02 PL PL08752572T patent/PL2155683T3/pl unknown
- 2008-05-02 AT AT08752572T patent/ATE502013T1/de active
- 2008-05-02 JP JP2009546541A patent/JP2010526026A/ja not_active Withdrawn
- 2008-05-02 AR ARP080101864A patent/AR066421A1/es unknown
- 2008-05-02 US US12/597,926 patent/US8173684B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100063098A1 (en) | 2010-03-11 |
| ATE502013T1 (de) | 2011-04-15 |
| WO2008140066A2 (en) | 2008-11-20 |
| JP2010526026A (ja) | 2010-07-29 |
| ES2363109T3 (es) | 2011-07-20 |
| MX2009011769A (es) | 2009-11-13 |
| CN101675034A (zh) | 2010-03-17 |
| EP2155683B8 (en) | 2011-09-21 |
| EP2155683B1 (en) | 2011-03-16 |
| EP2155683A2 (en) | 2010-02-24 |
| CA2686091A1 (en) | 2008-11-20 |
| WO2008140066A3 (en) | 2008-12-31 |
| TW200904421A (en) | 2009-02-01 |
| AR066421A1 (es) | 2009-08-19 |
| DE602008005581D1 (de) | 2011-04-28 |
| PT2155683E (pt) | 2011-04-11 |
| KR20100016563A (ko) | 2010-02-12 |
| US8173684B2 (en) | 2012-05-08 |
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