PL14736B1 - A method of obtaining bismuth hydroxide with a therapeutic effect. - Google Patents
A method of obtaining bismuth hydroxide with a therapeutic effect. Download PDFInfo
- Publication number
- PL14736B1 PL14736B1 PL14736A PL1473629A PL14736B1 PL 14736 B1 PL14736 B1 PL 14736B1 PL 14736 A PL14736 A PL 14736A PL 1473629 A PL1473629 A PL 1473629A PL 14736 B1 PL14736 B1 PL 14736B1
- Authority
- PL
- Poland
- Prior art keywords
- bismuth hydroxide
- therapeutic effect
- water
- ether
- obtaining bismuth
- Prior art date
Links
- 229940049676 bismuth hydroxide Drugs 0.000 title claims description 4
- TZSXPYWRDWEXHG-UHFFFAOYSA-K bismuth;trihydroxide Chemical compound [OH-].[OH-].[OH-].[Bi+3] TZSXPYWRDWEXHG-UHFFFAOYSA-K 0.000 title claims description 4
- 238000000034 method Methods 0.000 title claims description 3
- 230000001225 therapeutic effect Effects 0.000 title claims description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- PXUQTDZNOHRWLI-OXUVVOBNSA-O malvidin 3-O-beta-D-glucoside Chemical compound COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 PXUQTDZNOHRWLI-OXUVVOBNSA-O 0.000 claims 1
- 238000002360 preparation method Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229910052797 bismuth Inorganic materials 0.000 description 2
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 2
- 150000001622 bismuth compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000006379 syphilis Diseases 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229910000416 bismuth oxide Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960003750 ethyl chloride Drugs 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
Description
Zwiazki bizmutu, stosowane do leczenia kily, przewaznie w postaci soli kwasów or¬ ganicznych, posiadaja te wade, ze wskutek odbywajacej sie w tkankach hydrolizy wy¬ dzielaja sie kwasy silnie drazniace i powo¬ dujace bóle i przesieki. Równiez wolne od kwasów zwiazki bizmutu (Bi20^f BiO(OH) wywieraja szkodliwe wplywy uboczne.Chodzi tutaj prawdopodobnie o mechanicz¬ ne uszkodzenia tkanek wskutek silnego na¬ gryzania tych srodków, wedlug dotychcza¬ sowych sposobów bowiem nie mozna bylo otrzymac wymienionych polaczen zapomo- ca oliwy i podobnych srodków w postaci zawiesin;, które po zasifcrzyknleciu domie¬ sniowo lub podskórnie nie wywolywalyby szkodliwej reakcji.Stwierdzono, ze otrzymuje sie preparat, nadajacy sie znakomicie do wyzej wymie¬ nionego celu, suszac swiezo stracony wil¬ gotny wodorotlenek bizmutu Bi(OH)3 prziez usuwanie zen wodly zapomoca plóka- nia alkoholem, eterem lub podobnemi cie¬ czami. Otrzymuje sie w ten sposób bardzo lekki i delikatny proszek, który pod mi¬ kroskopem jest jednolity i który mozna bez trudnosci przerabiac z oliwa na bardzo drobnoziarniste zawiesiny. Analogicznie do doswiadczen Willstaitter'a nad innemi wo¬ dorotlenkami, równiez i w tym przypadku zapobiega sie chemicznym zmianom, po¬ wstajacym przy ogrzewaniu wodorotlenku w stanie wilgotnym. Doswiadczenia, doko¬ nane na zwierzetach i na ludziach w insty-tutach i klinikach uniwersyteckich, wyka- zialy, ze Wstezytówania te sa bezbolesne, ze nie w^l^ujs^po niólf ani przesieki, iani tez kinie stany zapalne lub szkodliwe dzialania uboczne, jak to stwierdzono przy uzyciu innych pmepairatów bizmutu, i ze równiez terapeutyczne dzialanie srodka otrzyma¬ nego wedlug wynalazku przy leczeniu kily jest znakomite. Otrzymany preparat na- dlaje sie równiez skutecznie db leczenia in¬ nych chorób, gdy wskazane jest stosowanie triuclnorozipuiSiZlczalnego, bardzo rozdrobnio¬ nego prepiaratu bizmutu, Pnzyklad. 18,4 kg tlenku bizmutu roz¬ puszcza sie w 401 kwasu azotowego (40°Be) i 40 1 wody na kapieli wodnej; po dodaniu dalszych 40 1 wody studzi sie powstaly roz¬ twór do zwyklej temperatury. Mieszajac wprowadza sie odsaczony roztwiór do mie¬ szaniny, .skladajacej sie z 300 1 amonjaku, o prawie 0,91 ciez. gat., i 2000 li wody.Po osadzeniu sie osadu odlewa sie ciecz 4 — 5 razy od zebranego osadu, a nastep¬ nie osad odsysa sie i plócze najpierw woda, potem alkoholem, a wreszcie eterem. Po wyparowaniu eteru otrzymuje sie produkt wi postaci delikatnego, lekkiego proszku, dajacy sie bez dalszego przygotowywania przerabiac na delikatne zawiesiny lub e- mulsje. Zamiast alkoholu uzyc mozna me¬ tanolu, acetonu i podobnych srodków, a za¬ miast eteru — chlorku etylu, chloroformu i podobnych srodków. PLThe bismuth compounds used in the treatment of syphilis, usually in the form of salts of organic acids, have the disadvantage that due to the hydrolysis of the tissues, acids are released that are highly irritating and cause pain and exudation. Also, acid-free bismuth compounds (Bi20-f BiO (OH) have harmful side effects. It is probably mechanical damage to tissues due to strong exposure to these substances, because according to the methods previously mentioned, it was not possible to obtain the above-mentioned combinations of oil and similar suspensions, which, if swallowed by intramuscular or subcutaneous injection, would not cause a harmful reaction. It has been found that a preparation is obtained which is perfectly suitable for the above-mentioned purpose by drying the freshly lost wet bismuth hydroxide Bi ( OH) 3 steps to remove the zen with water by staining with alcohol, ether or similar liquids, which gives a very light and fine powder which is homogeneous under a microscope and which can be easily processed from the oil into very fine-grained suspensions. By analogy with Willstaitter's experiments on other hydroxides, also in this case chemical changes, due to rising when heating the hydroxide in a wet state. Experiments on animals and humans in university institutes and clinics have shown that these anesthesia are painless, that they are not sore spots or exudates, and that they do not suffer from inflammation or harmful side effects. as has been found with other bismuth pmepairates, that also the therapeutic effect of the composition according to the invention is excellent in the treatment of syphilis. The preparation obtained can also be used effectively in the treatment of other diseases when it is advisable to use a tri-liquid, finely divided preparation of bismuth, Example. 18.4 kg of bismuth oxide are dissolved in 40 liters of nitric acid (40 ° Be) and 40 liters of water in a water bath; after addition of a further 40 liters of water, the resulting solution is cooled to its normal temperature. While stirring, the drained solution is introduced into the mixture, consisting of 300 liters of ammonia, of almost 0.91 weight. grade, and 2000 liters of water. After settling the sediment, the liquid is poured 4 - 5 times from the collected sediment, and then the sediment is sucked off and washed first with water, then with alcohol, and finally with ether. After the ether has evaporated, the product is obtained in the form of a fine, light powder, which can be processed into fine suspensions or emulsions without further preparation. Methanol, acetone, and the like may be used in place of alcohol, and ethyl chloride, chloroform and the like may be used in place of ether. PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL14736B1 true PL14736B1 (en) | 1931-11-30 |
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