PL140294B1 - Process for preparing l-3,4-dihydroxyphenylalanine - Google Patents
Process for preparing l-3,4-dihydroxyphenylalanine Download PDFInfo
- Publication number
- PL140294B1 PL140294B1 PL24310583A PL24310583A PL140294B1 PL 140294 B1 PL140294 B1 PL 140294B1 PL 24310583 A PL24310583 A PL 24310583A PL 24310583 A PL24310583 A PL 24310583A PL 140294 B1 PL140294 B1 PL 140294B1
- Authority
- PL
- Poland
- Prior art keywords
- dihydroxyphenylalanine
- chz
- general formula
- aqueous suspension
- industrial
- Prior art date
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title claims 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000007900 aqueous suspension Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000007071 enzymatic hydrolysis Effects 0.000 claims 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 239000003262 industrial enzyme Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 235000019833 protease Nutrition 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
- Zastrzezenia patentowe 1. Sposób otrzymywania L-3,4-dwuhydroksyfenyloalaniny na drodze hydrolizy enzymatycz¬ nej, znamienny tym, ze estry o wzorze ogólnym 1, w którym Rj oznacza wodór lub grupe metylowa, R^ oznacza grupe metylowa, etylowa lub propylowa, poddaje sie hydro¬ lizie proteazami przemyslowymi w zawiesinie wodnej w zakresie pH 6-9 i w temperaturze 20-55°C, wydzielajac nieprzereagowany ester przez wirowanie lub saczenie lub ekstrakcje a pozostala w roztworze pochodna L-N-benzoilo-3,4-dwuhydroksyfenyloalaniny o wzorze ogól¬ nym 2, przeprowadzajac znanymi metodami w 3,4-dwuhydroksyfenyloalanlne.
- 2. Sposób wedlug zastrzezenia 1, znamienny tym, ze reakcje hydrolizy prowadzi sie w zawiesinie wodnej o stezeniu substratu 5-20 %.
- 3. Sposób wedlug zastrzezenia 1, znamienny tym, ze jako enzymy przemy¬ slowe stosuje sie alkaliczne proteinazy bakteryjne lub enzymy proteolityczne trzustki.140 2# CH f-CHz-CH-COORz NH-CO Uzór Z ORf / CHjP*£ b-CHz-CH-COOH UzórZ Pracownia Poligraficzna UP PRL. Naklad 100 egz Cena 130 zl PL
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24310583A PL140294B1 (en) | 1983-07-20 | 1983-07-20 | Process for preparing l-3,4-dihydroxyphenylalanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL24310583A PL140294B1 (en) | 1983-07-20 | 1983-07-20 | Process for preparing l-3,4-dihydroxyphenylalanine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL243105A1 PL243105A1 (en) | 1985-01-30 |
| PL140294B1 true PL140294B1 (en) | 1987-04-30 |
Family
ID=20017977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL24310583A PL140294B1 (en) | 1983-07-20 | 1983-07-20 | Process for preparing l-3,4-dihydroxyphenylalanine |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL140294B1 (pl) |
-
1983
- 1983-07-20 PL PL24310583A patent/PL140294B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL243105A1 (en) | 1985-01-30 |
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