PH24784A - 8-trifluoromethyl quinolones as antibacterial agents - Google Patents

8-trifluoromethyl quinolones as antibacterial agents

Info

Publication number
PH24784A
PH24784A PH37363A PH37363A PH24784A PH 24784 A PH24784 A PH 24784A PH 37363 A PH37363 A PH 37363A PH 37363 A PH37363 A PH 37363A PH 24784 A PH24784 A PH 24784A
Authority
PH
Philippines
Prior art keywords
quinolones
trifluoromethyl
antibacterial agents
antibacterial
agents
Prior art date
Application number
PH37363A
Other languages
English (en)
Inventor
Alexander James Bridges
John Michael Domagala
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PH24784A publication Critical patent/PH24784A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PH37363A 1987-08-07 1988-08-05 8-trifluoromethyl quinolones as antibacterial agents PH24784A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/083,532 US4780468A (en) 1987-08-07 1987-08-07 8-trifluoromethyl quinolones as antibacterial agents

Publications (1)

Publication Number Publication Date
PH24784A true PH24784A (en) 1990-10-30

Family

ID=22178934

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37363A PH24784A (en) 1987-08-07 1988-08-05 8-trifluoromethyl quinolones as antibacterial agents

Country Status (12)

Country Link
US (1) US4780468A (de)
EP (1) EP0302525A3 (de)
JP (1) JPS6466180A (de)
KR (1) KR890003735A (de)
AU (2) AU616422B2 (de)
DK (1) DK439688A (de)
FI (1) FI883628A7 (de)
NO (1) NO883475L (de)
NZ (1) NZ225626A (de)
PH (1) PH24784A (de)
PT (1) PT88203A (de)
ZA (1) ZA885546B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3766299D1 (de) * 1986-07-04 1991-01-03 Chemie Linz Gmbh 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CA2012681A1 (en) * 1989-03-31 1990-09-30 Masayasu Okuhira Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DE69131428T2 (de) * 1990-11-30 2000-01-05 Warner-Lambert Co., Ann Arbor Individuelle stereoisomere von 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolone und naphthyridone als antibakterielle wirkstoffe
US5258528A (en) * 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
US5157128A (en) * 1990-11-30 1992-10-20 Warner-Lambert Company Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates
US5364861A (en) * 1990-11-30 1994-11-15 Warner-Lambert Company Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents
DE4301245A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Fluor-trifluormethylbenzoesäure-Derivate
DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
RU2140919C1 (ru) * 1994-07-18 1999-11-10 Убе Индастриз Лтд. Производные 8-трифторметилхинолинкарбоновой кислоты, фармацевтическая композиция и способ ингибирования вируса иммунодефицита
TW425394B (en) * 1996-04-24 2001-03-11 Daiichi Seiyaku Co Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group
WO1998007682A1 (fr) * 1996-08-19 1998-02-26 Ube Industries, Ltd. Acides trifluorobenzoiques substitues, esters de ces acides et procede de production
PE128799A1 (es) * 1997-09-15 2000-02-17 Procter & Gamble Quinolinas antimicrobianas y sus composiciones
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
KR100364226B1 (ko) * 1998-03-18 2003-01-24 주식회사 엘지생명과학 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법
SE0003795D0 (sv) * 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
KR20020072602A (ko) * 2001-03-12 2002-09-18 (주)인산 기능미의 제조방법
JP3729339B2 (ja) * 2001-10-03 2005-12-21 株式会社サタケ 発芽胚芽米の製造方法
KR100448505B1 (ko) * 2001-11-28 2004-09-13 삼서농업협동조합 발아현미 제조방법
WO2006109661A1 (ja) 2005-04-06 2006-10-19 Chugai Seiyaku Kabushiki Kaisha ２，３，４－トリフルオロ－５－（ヨード又はブロモ）安息香酸の製造方法
US7456279B2 (en) * 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
PL2001862T3 (pl) * 2006-03-28 2011-09-30 Warner Chilcott Co Llc Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
WO2007110836A1 (en) * 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
US8809552B2 (en) * 2011-11-01 2014-08-19 Hoffmann-La Roche Inc. Azetidine compounds, compositions and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB830832A (en) * 1957-02-15 1960-03-23 Ici Ltd New quinolones and therapeutic compositions containing them
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
EP0172004B1 (de) * 1984-08-15 1990-03-21 The Boots Company PLC Chinolinone, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Präparate
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
JPS62108878A (ja) * 1985-11-05 1987-05-20 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体およびその製造方法
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent

Also Published As

Publication number Publication date
DK439688D0 (da) 1988-08-05
JPS6466180A (en) 1989-03-13
DK439688A (da) 1989-02-08
AU2006088A (en) 1989-02-09
FI883628A0 (fi) 1988-08-03
EP0302525A2 (de) 1989-02-08
AU616422B2 (en) 1991-10-31
AU8374391A (en) 1991-11-14
NO883475L (no) 1989-02-08
PT88203A (pt) 1989-06-30
NO883475D0 (no) 1988-08-04
NZ225626A (en) 1991-03-26
ZA885546B (en) 1990-03-28
US4780468A (en) 1988-10-25
EP0302525A3 (de) 1990-08-22
KR890003735A (ko) 1989-04-17
FI883628A7 (fi) 1989-02-08

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