PH22607A - Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity - Google Patents
Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activityInfo
- Publication number
- PH22607A PH22607A PH32842A PH32842A PH22607A PH 22607 A PH22607 A PH 22607A PH 32842 A PH32842 A PH 32842A PH 32842 A PH32842 A PH 32842A PH 22607 A PH22607 A PH 22607A
- Authority
- PH
- Philippines
- Prior art keywords
- diuretic
- inhibitory activity
- converting enzyme
- angiotensin converting
- enzyme inhibitory
- Prior art date
Links
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 title 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 title 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 title 1
- 239000002220 antihypertensive agent Substances 0.000 title 1
- 239000002934 diuretic Substances 0.000 title 1
- 230000001882 diuretic effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/653,186 US4556655A (en) | 1984-09-24 | 1984-09-24 | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH22607A true PH22607A (en) | 1988-10-17 |
Family
ID=24619842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH32842A PH22607A (en) | 1984-09-24 | 1985-09-24 | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4556655A (fr) |
| EP (1) | EP0195817B1 (fr) |
| JP (1) | JPS62500241A (fr) |
| AU (1) | AU581388B2 (fr) |
| CA (1) | CA1278150C (fr) |
| DE (1) | DE3573784D1 (fr) |
| DK (1) | DK241686A (fr) |
| IL (1) | IL76484A (fr) |
| NZ (1) | NZ213581A (fr) |
| PH (1) | PH22607A (fr) |
| WO (1) | WO1986001803A1 (fr) |
| ZA (1) | ZA857358B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766110A (en) * | 1981-08-21 | 1988-08-23 | Ryan James W | Novel complex amido and imido derivatives of carboxyalkyl peptides |
| AU581929B2 (en) * | 1985-09-16 | 1989-03-09 | Schering Corporation | Antihypertensive agents, pharmaceutical compositions containing them and processes for the preparation of the agents and compositions |
| US4634689A (en) * | 1985-10-31 | 1987-01-06 | Schering Corporation | Phosphinylalkanoyl imino acids |
| TW442452B (en) * | 1996-03-01 | 2001-06-23 | Akzo Nobel Nv | Serine protease inhibitors having an alkynylamino side chain |
| JPWO2004065368A1 (ja) * | 2003-01-21 | 2006-05-18 | 大原薬品工業株式会社 | トランドラプリル合成中間体の製造方法 |
| JP2008545006A (ja) | 2005-07-05 | 2008-12-11 | シプラ・リミテッド | Ａｃｅ阻害剤の合成方法 |
| EP1864973A1 (fr) * | 2006-06-09 | 2007-12-12 | Sochinaz SA | Procede de preparation de perindopril et de sels de celui-ci |
| EP2454235A1 (fr) | 2009-07-16 | 2012-05-23 | Abbott Laboratories | Procédés de synthèse d'acide (2s, 3ar, 7as)-octahydro-1h-indole carboxylique comme intermédiaire pour le trandolapril |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0088350B1 (fr) * | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, leur procédé de préparation et leurs compositions pharmaceutiques les contenant |
| US4431644A (en) * | 1982-03-08 | 1984-02-14 | Schering Corporation | Antihypertensive agents |
| US4468396A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antihypertensive benzothiadiazines |
-
1984
- 1984-09-24 US US06/653,186 patent/US4556655A/en not_active Expired - Lifetime
-
1985
- 1985-09-19 EP EP85905015A patent/EP0195817B1/fr not_active Expired
- 1985-09-19 AU AU49639/85A patent/AU581388B2/en not_active Ceased
- 1985-09-19 JP JP60504453A patent/JPS62500241A/ja active Pending
- 1985-09-19 DE DE8585905015T patent/DE3573784D1/de not_active Expired
- 1985-09-19 WO PCT/US1985/001778 patent/WO1986001803A1/fr active IP Right Grant
- 1985-09-23 NZ NZ213581A patent/NZ213581A/xx unknown
- 1985-09-24 PH PH32842A patent/PH22607A/en unknown
- 1985-09-24 IL IL76484A patent/IL76484A/xx unknown
- 1985-09-24 ZA ZA857358A patent/ZA857358B/xx unknown
- 1985-09-24 CA CA000491447A patent/CA1278150C/fr not_active Expired - Fee Related
-
1986
- 1986-05-23 DK DK241686A patent/DK241686A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA857358B (en) | 1986-05-28 |
| IL76484A0 (en) | 1986-01-31 |
| CA1278150C (fr) | 1990-12-18 |
| US4556655A (en) | 1985-12-03 |
| EP0195817A1 (fr) | 1986-10-01 |
| IL76484A (en) | 1990-02-09 |
| NZ213581A (en) | 1989-04-26 |
| JPS62500241A (ja) | 1987-01-29 |
| AU4963985A (en) | 1986-04-08 |
| DK241686D0 (da) | 1986-05-23 |
| WO1986001803A1 (fr) | 1986-03-27 |
| DK241686A (da) | 1986-05-23 |
| DE3573784D1 (en) | 1989-11-23 |
| EP0195817B1 (fr) | 1989-10-18 |
| AU581388B2 (en) | 1989-02-16 |
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