PH12023550116A1 - Crystal of pyrimidine compound - Google Patents
Crystal of pyrimidine compoundInfo
- Publication number
- PH12023550116A1 PH12023550116A1 PH1/2023/550116A PH12023550116A PH12023550116A1 PH 12023550116 A1 PH12023550116 A1 PH 12023550116A1 PH 12023550116 A PH12023550116 A PH 12023550116A PH 12023550116 A1 PH12023550116 A1 PH 12023550116A1
- Authority
- PH
- Philippines
- Prior art keywords
- crystal
- compound
- powder
- ray diffraction
- characteristic peak
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 9
- -1 pyrimidine compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 6
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 5
- 238000001228 spectrum Methods 0.000 abstract 5
- 239000001530 fumaric acid Substances 0.000 abstract 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 3
- KJWHUTTYFUQYBW-WAOWUJCRSA-N 4-amino-6-(2-cyclopropylethynyl)-7-[(3R,5S)-5-methyl-1-prop-2-enoylpyrrolidin-3-yl]-N-[(1R)-1-phenylethyl]pyrrolo[2,3-d]pyrimidine-5-carboxamide Chemical compound C(C=C)(=O)N1C[C@@H](C[C@@H]1C)N1C(=C(C2=C1N=CN=C2N)C(=O)N[C@H](C)C1=CC=CC=C1)C#CC1CC1 KJWHUTTYFUQYBW-WAOWUJCRSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020121520 | 2020-07-15 | ||
| PCT/JP2021/026460 WO2022014638A1 (ja) | 2020-07-15 | 2021-07-14 | ピリミジン化合物の結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12023550116A1 true PH12023550116A1 (en) | 2024-06-24 |
Family
ID=79554693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2023/550116A PH12023550116A1 (en) | 2020-07-15 | 2021-07-14 | Crystal of pyrimidine compound |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12492208B2 (https=) |
| EP (1) | EP4183788A4 (https=) |
| JP (1) | JP7391226B2 (https=) |
| KR (1) | KR102914926B1 (https=) |
| CN (1) | CN116249534B (https=) |
| AU (1) | AU2021307245B2 (https=) |
| BR (1) | BR112023000765A2 (https=) |
| MX (1) | MX2023000692A (https=) |
| MY (1) | MY207540A (https=) |
| PH (1) | PH12023550116A1 (https=) |
| TW (1) | TWI905228B (https=) |
| WO (1) | WO2022014638A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4351737A4 (en) * | 2021-05-24 | 2025-05-14 | Taiho Pharmaceutical Co., Ltd. | Treatment methods for subjects with cancer having an aberration in egfr and/or her2 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8426428B2 (en) * | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
| TW201336847A (zh) * | 2012-02-07 | 2013-09-16 | Taiho Pharmaceutical Co Ltd | 喹啉基吡咯并嘧啶化合物或其鹽 |
| KR101852738B1 (ko) * | 2015-01-30 | 2018-04-27 | 다이호야쿠힌고교 가부시키가이샤 | 축합 피리미딘 화합물의 신규한 염 및 그 결정 |
| JP6537601B2 (ja) * | 2015-05-12 | 2019-07-03 | 大鵬薬品工業株式会社 | アザ二環式化合物の結晶 |
| BR112018004175B8 (pt) * | 2015-09-01 | 2023-10-31 | Taiho Pharmaceutical Co Ltd | Composto pirazolo[3,4-d]pirimidina, composição farmacêutica e usos terapêuticos do dito composto |
| KR102674711B1 (ko) * | 2017-02-28 | 2024-06-12 | 다이호야쿠힌고교 가부시키가이샤 | 피라졸로[3,4-d]피리미딘 화합물을 사용한 항종양 효과 증강제 |
| WO2020004546A1 (ja) | 2018-06-28 | 2020-01-02 | 日本電気株式会社 | 遠隔制御装置、遠隔制御方法及びプログラム |
| MA53509A (fr) | 2018-08-29 | 2021-07-07 | Taiho Pharmaceutical Co Ltd | Agent thérapeutique contenant un composé pyrazolo[3,4-d]pyrimidine comme ingrédient actif |
| PL3909584T3 (pl) * | 2019-01-11 | 2024-03-25 | Taiho Pharmaceutical Co., Ltd. | Związek pirymidynowy lub jego sól |
| JP7164455B2 (ja) | 2019-01-31 | 2022-11-01 | 理想科学工業株式会社 | 容器 |
| EP4183395A4 (en) | 2020-07-15 | 2024-07-24 | Taiho Pharmaceutical Co., Ltd. | PYRIMIDINE COMPOUND-CONTAINING COMBINATION FOR USE IN TUMOR TREATMENT |
| MX2023000693A (es) | 2020-07-15 | 2023-02-13 | Taiho Pharmaceutical Co Ltd | Inhibidor de egfr. |
-
2021
- 2021-07-14 BR BR112023000765A patent/BR112023000765A2/pt unknown
- 2021-07-14 TW TW110125852A patent/TWI905228B/zh active
- 2021-07-14 MY MYPI2023000055A patent/MY207540A/en unknown
- 2021-07-14 PH PH1/2023/550116A patent/PH12023550116A1/en unknown
- 2021-07-14 US US18/015,997 patent/US12492208B2/en active Active
- 2021-07-14 CN CN202180061122.XA patent/CN116249534B/zh active Active
- 2021-07-14 KR KR1020237003585A patent/KR102914926B1/ko active Active
- 2021-07-14 WO PCT/JP2021/026460 patent/WO2022014638A1/ja not_active Ceased
- 2021-07-14 MX MX2023000692A patent/MX2023000692A/es unknown
- 2021-07-14 AU AU2021307245A patent/AU2021307245B2/en active Active
- 2021-07-14 EP EP21842747.4A patent/EP4183788A4/en not_active Withdrawn
- 2021-07-14 JP JP2022536418A patent/JP7391226B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWI905228B (zh) | 2025-11-21 |
| JP7391226B2 (ja) | 2023-12-04 |
| JPWO2022014638A1 (https=) | 2022-01-20 |
| US20230331730A1 (en) | 2023-10-19 |
| KR20230034341A (ko) | 2023-03-09 |
| MX2023000692A (es) | 2023-02-13 |
| CA3189457A1 (en) | 2022-01-20 |
| US12492208B2 (en) | 2025-12-09 |
| WO2022014638A1 (ja) | 2022-01-20 |
| BR112023000765A2 (pt) | 2023-02-07 |
| CN116249534A (zh) | 2023-06-09 |
| EP4183788A1 (en) | 2023-05-24 |
| MY207540A (en) | 2025-03-04 |
| TW202216717A (zh) | 2022-05-01 |
| CN116249534B (zh) | 2025-03-25 |
| EP4183788A4 (en) | 2024-07-17 |
| KR102914926B1 (ko) | 2026-01-19 |
| AU2021307245B2 (en) | 2024-02-29 |
| AU2021307245A1 (en) | 2023-03-02 |
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