PH12022550360A1 - Tetracyclic compounds and their salts, compositions, and methods for their use - Google Patents

Tetracyclic compounds and their salts, compositions, and methods for their use

Info

Publication number
PH12022550360A1
PH12022550360A1 PH1/2022/550360A PH12022550360A PH12022550360A1 PH 12022550360 A1 PH12022550360 A1 PH 12022550360A1 PH 12022550360 A PH12022550360 A PH 12022550360A PH 12022550360 A1 PH12022550360 A1 PH 12022550360A1
Authority
PH
Philippines
Prior art keywords
salts
compositions
methods
tetracyclic compounds
methyl
Prior art date
Application number
PH1/2022/550360A
Other languages
English (en)
Inventor
John Soong
Original Assignee
Senhwa Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senhwa Biosciences Inc filed Critical Senhwa Biosciences Inc
Publication of PH12022550360A1 publication Critical patent/PH12022550360A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PH1/2022/550360A 2019-08-14 2020-08-14 Tetracyclic compounds and their salts, compositions, and methods for their use PH12022550360A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962886621P 2019-08-14 2019-08-14
US201962946774P 2019-12-11 2019-12-11
PCT/US2020/046329 WO2021030671A1 (en) 2019-08-14 2020-08-14 Tetracyclic compounds and their salts, compositions, and methods for their use

Publications (1)

Publication Number Publication Date
PH12022550360A1 true PH12022550360A1 (en) 2023-02-27

Family

ID=74568302

Family Applications (1)

Application Number Title Priority Date Filing Date
PH1/2022/550360A PH12022550360A1 (en) 2019-08-14 2020-08-14 Tetracyclic compounds and their salts, compositions, and methods for their use

Country Status (12)

Country Link
US (1) US20210046071A1 (https=)
EP (1) EP4013421A4 (https=)
JP (1) JP7566010B2 (https=)
KR (1) KR20220130085A (https=)
CN (1) CN114599368A (https=)
AU (1) AU2020328590B2 (https=)
BR (1) BR112022002784A2 (https=)
CA (1) CA3151112A1 (https=)
IL (1) IL290626A (https=)
PH (1) PH12022550360A1 (https=)
TW (1) TW202114694A (https=)
WO (1) WO2021030671A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7017509B2 (ja) 2015-11-20 2022-02-08 センワ バイオサイエンシズ インコーポレイテッド がんを治療するための四環式キノロン類似体の併用療法
CN112334133A (zh) 2018-02-15 2021-02-05 生华生物科技股份有限公司 喹诺酮类似物及其盐、组合物及其使用方法
CN114409681A (zh) * 2022-03-18 2022-04-29 信义核新(北京)生物科技有限公司 用于治疗dna损伤修复缺陷肿瘤的喹诺酮类似物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7928100B2 (en) * 2007-10-05 2011-04-19 Cylene Pharmaceuticals, Inc. Quinolone analogs and methods related thereto
US8853235B2 (en) * 2009-11-23 2014-10-07 Senhwa Biosciences, Inc. Polymorphs and salts of a kinase inhibitor
ES2754207T3 (es) * 2013-11-28 2020-04-16 Tel Hashomer Medical Res Infrastructure & Services Ltd Inhibidores de la ARN polimerasa I y usos de los mismos
JP7017509B2 (ja) * 2015-11-20 2022-02-08 センワ バイオサイエンシズ インコーポレイテッド がんを治療するための四環式キノロン類似体の併用療法
US9957282B2 (en) * 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
JP2018537486A (ja) * 2015-12-14 2018-12-20 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びその塩の結晶形
CN112334133A (zh) * 2018-02-15 2021-02-05 生华生物科技股份有限公司 喹诺酮类似物及其盐、组合物及其使用方法

Also Published As

Publication number Publication date
WO2021030671A1 (en) 2021-02-18
JP2022544559A (ja) 2022-10-19
US20210046071A1 (en) 2021-02-18
IL290626A (en) 2022-04-01
JP7566010B2 (ja) 2024-10-11
AU2020328590A1 (en) 2022-03-10
KR20220130085A (ko) 2022-09-26
AU2020328590B2 (en) 2026-03-26
EP4013421A1 (en) 2022-06-22
EP4013421A4 (en) 2023-08-23
TW202114694A (zh) 2021-04-16
CA3151112A1 (en) 2021-02-18
CN114599368A (zh) 2022-06-07
BR112022002784A2 (pt) 2022-08-09

Similar Documents

Publication Publication Date Title
MX2025002170A (es) Inhibidores de kras g12c
PH12022551574A1 (en) Egfr inhibitors
ZA202310378B (en) Complement factor b inhibitor, and pharmaceutical composition thereof, preparation method therefor and use thereof
EP4410291A3 (en) Erbb receptor inhibitors
CR20200376A (es) Inhibidores de cd73
PH12021550825A1 (en) Quinoline derivatives as alpha4beta7 integrin inhibitors
TN2017000374A1 (en) TGF-β INHIBITORS
ATE440603T1 (de) 8-hydroxychinolinderivate
PH12022550360A1 (en) Tetracyclic compounds and their salts, compositions, and methods for their use
GEP20084341B (en) Aminoheteroaryl compounds as protein kinase inhibitors
GEP20125589B (en) TRIAZINE COMPOUNDS AS P13 KINASE AND mTOR INHIBITORS
TNSN08529A1 (en) Inhibitors of akt (protein kinase b)
PH12021552513A1 (en) Pyrrole compounds
MX2020008678A (es) Metodos de uso para derivados de benzotriazol trisustituidos.
PH12022551241A1 (en) Egfr inhibitors
ZA202006071B (en) Antiproliferation compounds and uses thereof
UA96759C2 (en) 2-ARYLINDOLE DERIVATIVES AS mPGES-I INHIBITORS
ZA202210640B (en) Deuterated oxophenylarsine compound and use thereof
MX2021002878A (es) Inhibidores de cd73 y usos farmaceuticos de los mismos.
GEAP202415849A (en) Crystalline salt forms of kinase inhibitor
PH12021552953A1 (en) Tricyclic compounds
MY156955A (en) Antifungal agents
MX2025013372A (es) Inhibidores de gsk3\03b1 y metodos de uso de estos
MX2021005944A (es) Inhibidores de rip1.
MX2009005242A (es) Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo.