PH12016500414B1 - Solid preparation containing choline alfoscerate and method for preparing same - Google Patents

Solid preparation containing choline alfoscerate and method for preparing same

Info

Publication number
PH12016500414B1
PH12016500414B1 PH12016500414A PH12016500414A PH12016500414B1 PH 12016500414 B1 PH12016500414 B1 PH 12016500414B1 PH 12016500414 A PH12016500414 A PH 12016500414A PH 12016500414 A PH12016500414 A PH 12016500414A PH 12016500414 B1 PH12016500414 B1 PH 12016500414B1
Authority
PH
Philippines
Prior art keywords
solid preparation
choline alfoscerate
calcium silicate
containing choline
present
Prior art date
Application number
PH12016500414A
Other versions
PH12016500414A1 (en
Inventor
Youn Woong Choi
Byung Gu Min
Do Hyoung Ki
Hyung Joon Jun
Eun-Jung Choi
Sang Min Cho
Dae-Chul Ha
Hee-Chan Park
Hee-Yong Song
Original Assignee
Korea United Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea United Pharm Inc filed Critical Korea United Pharm Inc
Publication of PH12016500414A1 publication Critical patent/PH12016500414A1/en
Publication of PH12016500414B1 publication Critical patent/PH12016500414B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Abstract

The present invention relates to a solid preparation containing choline alfoscerate and calcium silicate, which enables a solid form of formulation by adsorbing calcium silicate to choline alfoscerate, and a preparation method thereof. The solid preparation of the present invention containing choline alfoscerate and calcium silicate has advantages in that it can reduce the risk of spoilage by microorganisms and deterioration of stability due to moisture, compared to that of soft capsule formulations, and has improved administration compliance due to its relatively small volume. Additionally, the present invention can improve early dissolution of the solid preparation using a mixed integrant of at least two kinds, thereby exhibiting a dissolution profile at a level equivalent to that of the existing soft capsules, and thus there is no difference in term of drug efficacies.
PH12016500414A 2014-07-08 2016-03-03 Solid preparation containing choline alfoscerate and method for preparing same PH12016500414B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140085171A KR101631846B1 (en) 2014-07-08 2014-07-08 Solid preparations containing choline alfoscerate and preparing method thereof
PCT/KR2015/006764 WO2016006862A1 (en) 2014-07-08 2015-07-01 Solid preparation comprising choline alfoscerate and method for preparing same

Publications (2)

Publication Number Publication Date
PH12016500414A1 PH12016500414A1 (en) 2016-05-16
PH12016500414B1 true PH12016500414B1 (en) 2016-05-16

Family

ID=55064433

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12016500414A PH12016500414B1 (en) 2014-07-08 2016-03-03 Solid preparation containing choline alfoscerate and method for preparing same

Country Status (3)

Country Link
KR (1) KR101631846B1 (en)
PH (1) PH12016500414B1 (en)
WO (1) WO2016006862A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101898669B1 (en) 2017-02-15 2018-10-31 콜마파마(주) A pharmaceutical capsule comprising choline alfoscerate and a method preparing the same
KR102210417B1 (en) 2018-04-24 2021-02-02 한국유나이티드제약 주식회사 Liquid formulation comprising choline alfoscerate
WO2019208898A1 (en) * 2018-04-24 2019-10-31 한국유나이티드제약 주식회사 Liquid syrup preparation containing choline alfoscerate
KR102221211B1 (en) 2019-02-13 2021-03-03 한국바이오켐제약 주식회사 Method of preparing choline alfoscerate and pharmaceutical composition comprising the same
KR20210105761A (en) 2020-02-19 2021-08-27 한국프라임제약주식회사 A sustained release dosage form comprising choline alphoscerate as an active ingredient

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4782695B2 (en) * 2004-10-25 2011-09-28 日本たばこ産業株式会社 Solid preparation with improved solubility and stability and method for producing the same
KR101499533B1 (en) 2008-02-15 2015-03-09 주식회사 씨티씨바이오 Pharmaceutical preparation containing choline alfoscerate
KR101573889B1 (en) * 2009-10-09 2015-12-04 영진약품공업주식회사 Immediate-release and sustained-release pharmaceutical composition
KR101172699B1 (en) 2011-05-16 2012-08-09 한국프라임제약주식회사 Pharmaceutical preparation comprising choline alfoscerate, and a method for manufacturing the same
KR101257919B1 (en) * 2011-07-14 2013-04-30 주식회사 바이오파마티스 Solid preparation for oral administration comprising choline alfoscerate or pharmaceutically acceptable salt thereof and method for manufacturing the same
KR101257918B1 (en) 2011-07-14 2013-04-30 주식회사 바이오파마티스 Sustained-release pharmaceutical composition comprising choline alfoscerate or pharmaceutically acceptable salt thereof and method for manufacturing the same

Also Published As

Publication number Publication date
KR101631846B1 (en) 2016-06-20
PH12016500414A1 (en) 2016-05-16
WO2016006862A1 (en) 2016-01-14
KR20160005971A (en) 2016-01-18

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