PH12015502000A1 - Processes and intermediates for preparing a medicament - Google Patents

Processes and intermediates for preparing a medicament

Info

Publication number
PH12015502000A1
PH12015502000A1 PH12015502000A PH12015502000A PH12015502000A1 PH 12015502000 A1 PH12015502000 A1 PH 12015502000A1 PH 12015502000 A PH12015502000 A PH 12015502000A PH 12015502000 A PH12015502000 A PH 12015502000A PH 12015502000 A1 PH12015502000 A1 PH 12015502000A1
Authority
PH
Philippines
Prior art keywords
intermediates
processes
medicament
preparing
useful
Prior art date
Application number
PH12015502000A
Inventor
Pye Philip
Ben Haim Cyril
Conza Matteo
Houpis Ioannis Nicolaos
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50239639&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH12015502000(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2014/054621 external-priority patent/WO2014139970A1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PH12015502000A1 publication Critical patent/PH12015502000A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

Disclosed is a process for the preparation of the following compounds: (I), (II) where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesise downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.
PH12015502000A 2013-03-15 2015-09-08 Processes and intermediates for preparing a medicament PH12015502000A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361786842P 2013-03-15 2013-03-15
EP13159470 2013-03-15
EP13197813 2013-12-17
PCT/EP2014/054621 WO2014139970A1 (en) 2013-03-15 2014-03-11 Processes and intermediates for preparing a medicament

Publications (1)

Publication Number Publication Date
PH12015502000A1 true PH12015502000A1 (en) 2016-01-11

Family

ID=50239639

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12015502000A PH12015502000A1 (en) 2013-03-15 2015-09-08 Processes and intermediates for preparing a medicament

Country Status (5)

Country Link
CL (1) CL2015002668A1 (en)
HK (1) HK1216178A1 (en)
IL (1) IL240533A0 (en)
PE (1) PE20211448A1 (en)
PH (1) PH12015502000A1 (en)

Also Published As

Publication number Publication date
PE20211448A1 (en) 2021-08-05
IL240533A0 (en) 2015-10-29
CL2015002668A1 (en) 2016-03-04
HK1216178A1 (en) 2016-10-21
NZ711026A (en) 2021-01-29

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