PE20211448A1 - PROCESSES AND INTERMEDIATES TO PREPARE A MEDICATION - Google Patents
PROCESSES AND INTERMEDIATES TO PREPARE A MEDICATIONInfo
- Publication number
- PE20211448A1 PE20211448A1 PE2020001350A PE2020001350A PE20211448A1 PE 20211448 A1 PE20211448 A1 PE 20211448A1 PE 2020001350 A PE2020001350 A PE 2020001350A PE 2020001350 A PE2020001350 A PE 2020001350A PE 20211448 A1 PE20211448 A1 PE 20211448A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- medication
- intermediates
- prepare
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Referido a un proceso para preparar un compuesto de formula I, o un derivado del mismo, donde: R1 representa H o, un grupo protector de nitrogeno seleccionado de terc-butoxicarbonilo (Boc), carboxibencilo (Cbz) o bencilo (Bn); dicho proceso comprende la reaccion de un compuesto de formula (a), en donde EWG es -CO2Et, CONH2; con un compuesto de formula III. Tambien se refiere a compuestos intermedio de dicho compuesto, un proceso para preparar ibrutinib, y una formulacion farmaceutica que lo comprenda.Referring to a process for preparing a compound of formula I, or a derivative thereof, where: R1 represents H or, a nitrogen protecting group selected from tert-butoxycarbonyl (Boc), carboxybenzyl (Cbz) or benzyl (Bn); said process comprises the reaction of a compound of formula (a), wherein EWG is -CO2Et, CONH2; with a compound of formula III. It also refers to intermediate compounds of said compound, a process for preparing ibrutinib, and a pharmaceutical formulation comprising it.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786842P | 2013-03-15 | 2013-03-15 | |
| EP13159470 | 2013-03-15 | ||
| EP13197813 | 2013-12-17 | ||
| PCT/EP2014/054621 WO2014139970A1 (en) | 2013-03-15 | 2014-03-11 | Processes and intermediates for preparing a medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20211448A1 true PE20211448A1 (en) | 2021-08-05 |
Family
ID=50239639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020001350A PE20211448A1 (en) | 2013-03-15 | 2014-03-11 | PROCESSES AND INTERMEDIATES TO PREPARE A MEDICATION |
Country Status (5)
| Country | Link |
|---|---|
| CL (1) | CL2015002668A1 (en) |
| HK (1) | HK1216178A1 (en) |
| IL (1) | IL240533A0 (en) |
| PE (1) | PE20211448A1 (en) |
| PH (1) | PH12015502000A1 (en) |
-
2014
- 2014-03-11 PE PE2020001350A patent/PE20211448A1/en unknown
-
2015
- 2015-08-12 IL IL240533A patent/IL240533A0/en active IP Right Review Request
- 2015-09-08 PH PH12015502000A patent/PH12015502000A1/en unknown
- 2015-09-14 CL CL2015002668A patent/CL2015002668A1/en unknown
-
2016
- 2016-04-13 HK HK16104203.7A patent/HK1216178A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ711026A (en) | 2021-01-29 |
| HK1216178A1 (en) | 2016-10-21 |
| IL240533A0 (en) | 2015-10-29 |
| PH12015502000A1 (en) | 2016-01-11 |
| CL2015002668A1 (en) | 2016-03-04 |
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