PH12015500331A1 - Trans-clomiphene formulations and uses thereof - Google Patents
Trans-clomiphene formulations and uses thereofInfo
- Publication number
- PH12015500331A1 PH12015500331A1 PH12015500331A PH12015500331A PH12015500331A1 PH 12015500331 A1 PH12015500331 A1 PH 12015500331A1 PH 12015500331 A PH12015500331 A PH 12015500331A PH 12015500331 A PH12015500331 A PH 12015500331A PH 12015500331 A1 PH12015500331 A1 PH 12015500331A1
- Authority
- PH
- Philippines
- Prior art keywords
- clomiphene
- trans
- cancer
- solvates
- pharmaceutically acceptable
- Prior art date
Links
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000012453 solvate Substances 0.000 abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010014476 Elevated cholesterol Diseases 0.000 abstract 1
- 206010014486 Elevated triglycerides Diseases 0.000 abstract 1
- 208000007984 Female Infertility Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010020880 Hypertrophy Diseases 0.000 abstract 1
- 206010021928 Infertility female Diseases 0.000 abstract 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 abstract 1
- 208000007466 Male Infertility Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 206010059594 Secondary hypogonadism Diseases 0.000 abstract 1
- 229960003608 clomifene Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 abstract 1
- 208000006132 lipodystrophy Diseases 0.000 abstract 1
- 201000004228 ovarian endometrial cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Neurology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261691722P | 2012-08-21 | 2012-08-21 | |
| PCT/US2013/032659 WO2014031177A1 (en) | 2012-08-21 | 2013-03-15 | Trans-clomiphene formulations and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12015500331A1 true PH12015500331A1 (en) | 2015-04-20 |
Family
ID=48014380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12015500331A PH12015500331A1 (en) | 2012-08-21 | 2015-02-16 | Trans-clomiphene formulations and uses thereof |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20150202167A1 (enExample) |
| EP (1) | EP2887922A1 (enExample) |
| JP (2) | JP2015527360A (enExample) |
| KR (1) | KR20150041793A (enExample) |
| CN (1) | CN104582686A (enExample) |
| AU (1) | AU2013306393A1 (enExample) |
| BR (1) | BR112015002288A2 (enExample) |
| CA (1) | CA2880388A1 (enExample) |
| CL (1) | CL2015000311A1 (enExample) |
| CR (1) | CR20150096A (enExample) |
| EA (1) | EA201590421A1 (enExample) |
| HK (1) | HK1209636A1 (enExample) |
| IL (1) | IL236911A0 (enExample) |
| IN (1) | IN2015DN01698A (enExample) |
| MX (1) | MX2015001912A (enExample) |
| NI (1) | NI201500022A (enExample) |
| NZ (1) | NZ704679A (enExample) |
| PH (1) | PH12015500331A1 (enExample) |
| SG (2) | SG10201704820SA (enExample) |
| UA (1) | UA113324C2 (enExample) |
| WO (1) | WO2014031177A1 (enExample) |
| ZA (1) | ZA201501124B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| CN104994877A (zh) | 2012-11-02 | 2015-10-21 | 利普生物药剂公司 | 用于癌症治疗的反式-克罗米芬 |
| EP3015453B1 (en) | 2014-10-28 | 2016-10-12 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of Clomiphene |
| EP3015454A1 (en) | 2014-10-28 | 2016-05-04 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Stable solid form of trans-Clomiphene citrate |
| US11737934B2 (en) | 2015-10-14 | 2023-08-29 | Qfix Systems, Llc | MRI compatible patient trolley |
| CN108463453A (zh) * | 2016-04-22 | 2018-08-28 | 意大利合成制造有限公司 | 用于制备具有针状晶体习性的柠檬酸恩氯米芬的方法 |
| CA3098552A1 (en) | 2019-11-14 | 2021-05-14 | Apotex Inc. | Processes for the preparation of zuclomiphene and intermediates thereof |
| CA3098725A1 (en) | 2019-11-14 | 2021-05-14 | Apotex Inc. | Zuclpomiphene salts and crystalline forms thereof |
| CA3105944A1 (en) | 2020-01-22 | 2021-07-22 | Apotex Inc. | Crystalline forms of zuclomiphene citrate |
| EP3907213A1 (en) | 2020-05-04 | 2021-11-10 | Pcas | Processes for the production of isomerically pure or enriched cis-clomiphene |
| US11578025B2 (en) | 2020-10-19 | 2023-02-14 | Apotex Inc. | Processes for the preparation of zuclomiphene intermediates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2914563A (en) | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Therapeutic composition |
| IT951631B (it) | 1971-03-18 | 1973-07-10 | Richardson Merrell Spa | Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi |
| CN1289075C (zh) * | 2001-07-09 | 2006-12-13 | 佐纳根有限公司 | 富含反式克罗米酚的克罗米酚组合物的用途 |
| RU2006138235A (ru) * | 2004-03-31 | 2008-05-10 | Трофоджен, Инк. (Us) | Суперагонисты человеческих гликопротеиновых гормонов и способы их применения |
| EP1776098A1 (en) | 2004-07-14 | 2007-04-25 | Repros Therapeutics Inc. | Trans-clomiphene for the treatment of benign prostate hypertrophy, prostate cancer, hypogonadism, elevated triglycerides and high cholesterol |
| WO2007095716A1 (en) * | 2006-02-23 | 2007-08-30 | Iomedix Sleep International Srl | Compositions and methods for the induction and maintenance of quality sleep |
| MX2010004195A (es) | 2007-10-16 | 2010-06-02 | Repros Therapeutics Inc | Trans-clomifeno para el sindrome metabolico. |
| TWI458478B (zh) * | 2008-11-07 | 2014-11-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
-
2013
- 2013-03-15 SG SG10201704820SA patent/SG10201704820SA/en unknown
- 2013-03-15 CN CN201380044056.0A patent/CN104582686A/zh active Pending
- 2013-03-15 WO PCT/US2013/032659 patent/WO2014031177A1/en not_active Ceased
- 2013-03-15 MX MX2015001912A patent/MX2015001912A/es unknown
- 2013-03-15 JP JP2015528460A patent/JP2015527360A/ja not_active Withdrawn
- 2013-03-15 HK HK15110434.6A patent/HK1209636A1/xx unknown
- 2013-03-15 IN IN1698DEN2015 patent/IN2015DN01698A/en unknown
- 2013-03-15 AU AU2013306393A patent/AU2013306393A1/en not_active Abandoned
- 2013-03-15 CA CA2880388A patent/CA2880388A1/en not_active Abandoned
- 2013-03-15 KR KR20157004972A patent/KR20150041793A/ko not_active Withdrawn
- 2013-03-15 EA EA201590421A patent/EA201590421A1/ru unknown
- 2013-03-15 US US14/421,119 patent/US20150202167A1/en not_active Abandoned
- 2013-03-15 EP EP13713053.0A patent/EP2887922A1/en not_active Withdrawn
- 2013-03-15 SG SG11201500641TA patent/SG11201500641TA/en unknown
- 2013-03-15 NZ NZ704679A patent/NZ704679A/en not_active IP Right Cessation
- 2013-03-15 BR BR112015002288A patent/BR112015002288A2/pt not_active IP Right Cessation
- 2013-03-15 UA UAA201502474A patent/UA113324C2/uk unknown
-
2015
- 2015-01-25 IL IL236911A patent/IL236911A0/en unknown
- 2015-02-09 CL CL2015000311A patent/CL2015000311A1/es unknown
- 2015-02-16 PH PH12015500331A patent/PH12015500331A1/en unknown
- 2015-02-17 NI NI201500022A patent/NI201500022A/es unknown
- 2015-02-18 ZA ZA2015/01124A patent/ZA201501124B/en unknown
- 2015-02-25 CR CR20150096A patent/CR20150096A/es unknown
-
2017
- 2017-08-31 JP JP2017167061A patent/JP2017206562A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL236911A0 (en) | 2015-03-31 |
| EA201590421A1 (ru) | 2015-06-30 |
| WO2014031177A1 (en) | 2014-02-27 |
| KR20150041793A (ko) | 2015-04-17 |
| CR20150096A (es) | 2015-05-04 |
| NI201500022A (es) | 2016-02-01 |
| US20150202167A1 (en) | 2015-07-23 |
| JP2015527360A (ja) | 2015-09-17 |
| NZ704679A (en) | 2016-02-26 |
| SG10201704820SA (en) | 2017-07-28 |
| AU2013306393A1 (en) | 2015-02-19 |
| ZA201501124B (en) | 2016-04-28 |
| BR112015002288A2 (pt) | 2017-07-04 |
| SG11201500641TA (en) | 2015-04-29 |
| IN2015DN01698A (enExample) | 2015-07-03 |
| CA2880388A1 (en) | 2014-02-27 |
| HK1209636A1 (en) | 2016-04-08 |
| UA113324C2 (xx) | 2017-01-10 |
| CN104582686A (zh) | 2015-04-29 |
| EP2887922A1 (en) | 2015-07-01 |
| CL2015000311A1 (es) | 2015-08-14 |
| MX2015001912A (es) | 2015-06-05 |
| JP2017206562A (ja) | 2017-11-24 |
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