PE2298A1 - Metodos para minimizar la perdida osea - Google Patents

Metodos para minimizar la perdida osea

Info

Publication number
PE2298A1
PE2298A1 PE1996000409A PE00040996A PE2298A1 PE 2298 A1 PE2298 A1 PE 2298A1 PE 1996000409 A PE1996000409 A PE 1996000409A PE 00040996 A PE00040996 A PE 00040996A PE 2298 A1 PE2298 A1 PE 2298A1
Authority
PE
Peru
Prior art keywords
administration
alkyl
compound
osea
pirrolidinyl
Prior art date
Application number
PE1996000409A
Other languages
English (en)
Inventor
George Joseph Cullinan
Andrew Lawrence Glasebrook
Steven Anthony Fontana
Robin Sharon Lee Fuchs-Young
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE2298A1 publication Critical patent/PE2298A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

CARACTERIZADO POR CONTRARRESTAR EL EFECTO DE DE LA PERDIDA OSEA INDUCIDA POR LA ADMINISTRACION DE UN COMPUESTO DE FORMULA (I), EN DONDE: R ES -CH2CON(CH3)-n-(CH2)3-CH3 o -SO(CH2)3CF2CF3, QUE COMPRENDE: ADMINISTRAR UN COMPUESTO DE FORMULA (II), EN DONDE: R1 ES H, -O-ALQUILO C1-C4), -OCOC6H5, -OCO-ALQUILO C1-C6, o SO2-ALQUILO C4-C6; R2 ES PIRROLIDINILO, METIL-1-PIRROLIDINILO, DIMETIL-1-PIRROLIDINO, 4-MORFOLINO, DIMETIL- o DIETIL- AMINO, 1-HEXAMETILENIMINO o 1-PIPERIDINILO; REFIRIENDOSE PREFERENTEMENTE AL RALOXIFENO, CON LA OPCIONAL COADMINISTRACION DE UN AGENTE ANABOLICO OSEO, TAL COMO: LA PTH (1-84) o PTH (1-34). ESTA ADMINISTRACION ES SECUENCIAL O CONCOMITANTE, SEGUN LA GRAVEDAD DEL TRANSTORNO, DE LA VIA DE ADMINISTRACION Y DE OTROS FACTORES RELACIONADOS DETERMINADOS, EN LA ADMINISTRACION DEL COMPUESTO (I), PARA TRATAR UNA ENFERMEDAD CRONICA, TAL COMO ENDOMETROSIS O TERAPIA ADYUVANTE EN EL CANCER DESPUES DE LA CIRUGIA
PE1996000409A 1995-06-06 1996-06-05 Metodos para minimizar la perdida osea PE2298A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47111195A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
PE2298A1 true PE2298A1 (es) 1998-02-28

Family

ID=23870302

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000409A PE2298A1 (es) 1995-06-06 1996-06-05 Metodos para minimizar la perdida osea

Country Status (27)

Country Link
EP (1) EP0747056B1 (es)
JP (1) JP2001501907A (es)
KR (1) KR19990022497A (es)
CN (1) CN1239429A (es)
AR (2) AR003134A1 (es)
AT (1) ATE187643T1 (es)
AU (1) AU696927B2 (es)
BR (1) BR9608390A (es)
CA (1) CA2223174A1 (es)
CO (1) CO4700447A1 (es)
CZ (1) CZ383097A3 (es)
DE (1) DE69605600T2 (es)
DK (1) DK0747056T3 (es)
EA (1) EA199800014A1 (es)
ES (1) ES2142545T3 (es)
GR (1) GR3032863T3 (es)
HU (1) HUP9900854A3 (es)
IL (1) IL118573A (es)
NO (1) NO975560L (es)
PE (1) PE2298A1 (es)
PL (1) PL323941A1 (es)
PT (1) PT747056E (es)
SI (1) SI0747056T1 (es)
TR (1) TR199701508T1 (es)
WO (1) WO1996039141A1 (es)
YU (1) YU34296A (es)
ZA (1) ZA964681B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5558498A (en) * 1996-11-22 1998-06-22 Akzo Nobel N.V. Bmp-4 promoter and use thereof in screening of therapeutic agents for the prevention and/or treatment of osteoporosis
GB2324726A (en) * 1997-05-01 1998-11-04 Merck & Co Inc Combination Therapy for the Treatment of Osteoporosis
US6096764A (en) * 1997-08-21 2000-08-01 Eli Lilly And Company Methods for inhibiting detrimental side-effects due to GnRH of GnRH agonist administration
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895715A (en) * 1988-04-14 1990-01-23 Schering Corporation Method of treating gynecomastia
US5393785A (en) * 1988-10-31 1995-02-28 Endorecherche, Inc. Therapeutic antiestrogens
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
DE4329344A1 (de) * 1993-08-27 1995-03-02 Schering Ag Progesteronantagonistisch- und antiöstrogen wirksame Verbindungen für die Behandlung des Leiomyomata uteri

Also Published As

Publication number Publication date
TR199701508T1 (xx) 1998-03-21
WO1996039141A1 (en) 1996-12-12
KR19990022497A (ko) 1999-03-25
AR003002A1 (es) 1998-05-27
CZ383097A3 (cs) 1998-09-16
DE69605600D1 (de) 2000-01-20
SI0747056T1 (en) 2000-06-30
BR9608390A (pt) 1999-05-04
EP0747056A2 (en) 1996-12-11
IL118573A0 (en) 1996-10-16
ES2142545T3 (es) 2000-04-16
EP0747056A3 (en) 1997-03-05
DE69605600T2 (de) 2000-05-31
DK0747056T3 (da) 2000-05-01
IL118573A (en) 2000-01-31
GR3032863T3 (en) 2000-07-31
ATE187643T1 (de) 2000-01-15
CO4700447A1 (es) 1998-12-29
PL323941A1 (en) 1998-04-27
CN1239429A (zh) 1999-12-22
EP0747056B1 (en) 1999-12-15
PT747056E (pt) 2000-05-31
YU34296A (en) 1999-11-22
ZA964681B (en) 1997-12-05
HUP9900854A2 (hu) 1999-08-30
NO975560D0 (no) 1997-12-02
JP2001501907A (ja) 2001-02-13
AU5981696A (en) 1996-12-24
AU696927B2 (en) 1998-09-24
CA2223174A1 (en) 1996-12-12
EA199800014A1 (ru) 1998-06-25
NO975560L (no) 1998-01-26
HUP9900854A3 (en) 2000-03-28
AR003134A1 (es) 1998-07-08

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