PE20171095A1 - NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION WITH BIOMOLECULES - Google Patents

NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION WITH BIOMOLECULES

Info

Publication number
PE20171095A1
PE20171095A1 PE2016002771A PE2016002771A PE20171095A1 PE 20171095 A1 PE20171095 A1 PE 20171095A1 PE 2016002771 A PE2016002771 A PE 2016002771A PE 2016002771 A PE2016002771 A PE 2016002771A PE 20171095 A1 PE20171095 A1 PE 20171095A1
Authority
PE
Peru
Prior art keywords
biomolecules
conjugation
fatty acids
acid
novel fatty
Prior art date
Application number
PE2016002771A
Other languages
Spanish (es)
Inventor
Chikwendu Ibebunjo
Alexandra Marshall Bruce
Avirup Bose
David Weninger Barnes
Ken Yamada
Aaron Kanter
Alokesh Duttaroy
Louise Clare Kirman
Aimee Richardson Usera
Frederic Zecri
Jun Yuan
Changgang Lou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53491695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20171095(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20171095A1 publication Critical patent/PE20171095A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/22—Tricarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Abstract

Se refiere a un conjugado de GDF15 que comprende una biomolecula enlazada a un acido graso por medio de un enlazador, en donde en acido graso tiene las siguientes formulas A1, A2 o A3; donde R1 es CO2H o H; R2, R3 y R4 son H, OH, entre otros; Ak es alquileno de 6 a 30 atomos de carbono ramificado; n, m y p son enteros entre 6 y 30 o amidas, entre otros. Es un acido preferente: acido 2-undecil-manolico, entre otros. Tambien se refiere a una combinacion y una composicion farmaceutica que la comprende. Dicho conjugado es util en el tratamiento de enfermedades metabolicas, diabetes mellitus tipo 2, pancreatitis, entre otrosIt refers to a GDF15 conjugate that comprises a biomolecule linked to a fatty acid through a linker, wherein in fatty acid it has the following formulas A1, A2 or A3; where R1 is CO2H or H; R2, R3 and R4 are H, OH, among others; Ak is alkylene of 6 to 30 branched carbon atoms; n, m and p are integers between 6 and 30 or amides, among others. It is a preferred acid: 2-undecyl-manolic acid, among others. It also refers to a combination and a pharmaceutical composition comprising it. This conjugate is useful in the treatment of metabolic diseases, type 2 diabetes mellitus, pancreatitis, among others.

PE2016002771A 2014-06-23 2015-06-18 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION WITH BIOMOLECULES PE20171095A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23

Publications (1)

Publication Number Publication Date
PE20171095A1 true PE20171095A1 (en) 2017-08-07

Family

ID=53491695

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016002771A PE20171095A1 (en) 2014-06-23 2015-06-18 NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION WITH BIOMOLECULES

Country Status (37)

Country Link
US (4) US10588980B2 (en)
EP (2) EP3988170A1 (en)
JP (5) JP6636959B2 (en)
KR (2) KR20230056796A (en)
CN (3) CN114133443A (en)
AP (1) AP2016009585A0 (en)
AU (1) AU2015280351C1 (en)
CA (1) CA2953480A1 (en)
CL (1) CL2016003281A1 (en)
CR (1) CR20160596A (en)
CU (1) CU24455B1 (en)
CY (1) CY1125006T1 (en)
DK (1) DK3157571T3 (en)
EA (1) EA039074B1 (en)
EC (1) ECSP17004665A (en)
ES (1) ES2905479T3 (en)
GT (1) GT201600263A (en)
HK (1) HK1232160A1 (en)
HR (1) HRP20220152T1 (en)
HU (1) HUE057845T2 (en)
IL (1) IL248990B (en)
JO (1) JO3813B1 (en)
LT (1) LT3157571T (en)
MA (1) MA40278A (en)
MX (1) MX367520B (en)
MY (1) MY193993A (en)
PE (1) PE20171095A1 (en)
PH (1) PH12016502294B1 (en)
PL (1) PL3157571T3 (en)
PT (1) PT3157571T (en)
RS (1) RS62907B1 (en)
SG (2) SG10201912965TA (en)
SI (1) SI3157571T1 (en)
TN (1) TN2016000558A1 (en)
TW (3) TWI750725B (en)
UY (1) UY36186A (en)
WO (1) WO2015200078A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
CN103533951B (en) 2011-04-08 2017-04-19 安姆根有限公司 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
EA202092386A1 (en) 2013-07-31 2021-04-30 Эмджен Инк. CONSTRUCTIONS BASED ON DIFFERENTIATION AND GROWTH FACTOR 15 (GDF15)
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
KR20170084332A (en) 2014-12-04 2017-07-19 노파르티스 아게 Methods and compositions using klotho variant polypeptides
MX2017009534A (en) * 2015-01-23 2018-04-10 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life.
US20190000923A1 (en) * 2015-12-22 2019-01-03 Novartis Ag Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
CA3011894A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
KR101727506B1 (en) * 2016-07-14 2017-05-04 충남대학교 산학협력단 Pharmaceutical composition for the prevention or treatment of fat liver comprising GDF15 protein or polynucleotide encoding GDF15 as an effective ingredient
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
MX2019008675A (en) 2017-01-23 2019-09-18 Regeneron Pharma Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof.
CA3052639A1 (en) 2017-02-08 2018-08-16 Bristol-Myers Squibb Company Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
AU2018250727A1 (en) 2017-04-11 2019-10-31 Regeneron Pharmaceuticals, Inc. Assays for screening activity of modulators of members of the hydroxysteroid (17-beta) dehydrogenase (HSD17B) family
AU2018269568B2 (en) * 2017-05-18 2022-03-24 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
TWI710377B (en) * 2017-05-23 2020-11-21 丹麥商諾佛 儂迪克股份有限公司 Mic-1 compounds and uses thereof
CA3078883A1 (en) 2017-10-11 2019-04-18 Regeneron Pharmaceuticals, Inc. Inhibition of hsd17b13 in the treatment of liver disease in patients expressing the pnpla3 i148m variation
TW202344266A (en) * 2017-12-22 2023-11-16 瑞士商諾華公司 Methods of treating metabolic disorders with fgf21 variants
WO2019179494A1 (en) * 2018-03-23 2019-09-26 深圳市塔吉瑞生物医药有限公司 Substituted pentadecanedioic acid compound and pharmaceutical composition and use thereof
CR20200510A (en) 2018-04-09 2020-11-26 Amgen Inc Growth differentiation factor 15 fusion proteins
AU2019277029C1 (en) 2018-06-01 2024-01-04 Novartis Ag Binding molecules against BCMA and uses thereof
JP2021533762A (en) 2018-08-10 2021-12-09 ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts Modified oligonucleotides that target SNPs
CN112543869A (en) 2018-08-10 2021-03-23 诺华股份有限公司 GFRAL extracellular domains and methods of use
TW202023573A (en) * 2018-09-19 2020-07-01 美商Ionis製藥公司 Modulators of pnpla3 expression
JP2022513363A (en) * 2018-10-22 2022-02-07 ヤンセン ファーマシューティカ エヌ．ベー． Glucagon-like peptide 1 (GLP1) -proliferation differentiation factor 15 (GDF15) fusion protein and its use
JP2022513626A (en) 2018-11-26 2022-02-09 ノバルティス アーゲー LPL-GPIHBP1 fusion polypeptide
SG11202111570TA (en) * 2019-04-23 2021-11-29 Lg Chemical Ltd Fusion polypeptide comprising fc region of immunoglobulin and gdf15
CN111909256A (en) * 2019-05-10 2020-11-10 宁波鲲鹏生物科技有限公司 Polypeptide derivatives and process for preparing the same
US20230071196A1 (en) 2019-05-21 2023-03-09 Novartis Ag Variant cd58 domains and uses thereof
TW202100559A (en) 2019-05-21 2021-01-01 瑞士商諾華公司 Cd19 binding molecules and uses thereof
WO2021016043A1 (en) * 2019-07-19 2021-01-28 Inari Agriculture, Inc. Improved homology dependent repair genome editing
EP4041281A1 (en) 2019-10-04 2022-08-17 Amgen Inc. Use of gdf15 for treating cardiometabolic syndrome and other conditions
JP2023500763A (en) 2019-11-04 2023-01-11 フェリング ベスローテン フェンノートシャップ Intranasal administration of melotocin to improve lactation
BR112022009976A2 (en) * 2019-11-26 2022-10-04 Dtx Pharma Inc COMPOUND COMPRISING A NUCLEIC ACID AND HALF-LIFE EXTENSION REASON
WO2021126990A1 (en) * 2019-12-16 2021-06-24 The Scripps Research Institute Oxytocin derivatives with improved properties
CN116925237A (en) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Fusion proteins of GLP-1 and GDF15 and conjugates thereof
CN115243727A (en) * 2020-01-13 2022-10-25 西纳福克斯股份有限公司 Bilaterally functionalized antibodies via cycloaddition
JP2023511857A (en) * 2020-01-13 2023-03-23 シンアフィックス ビー．ブイ． Antibodies bilaterally functionalized via cycloaddition
EP4090377A1 (en) * 2020-01-13 2022-11-23 Synaffix B.V. Conjugates of antibodies an immune cell engagers
WO2022097060A1 (en) 2020-11-06 2022-05-12 Novartis Ag Cd19 binding molecules and uses thereof
KR102543789B1 (en) * 2021-03-08 2023-06-20 주식회사 온코크로스 Composition for preventing or treating metabolic disease comprising torsemide and cromolyn
WO2022219495A1 (en) 2021-04-12 2022-10-20 Novartis Ag 2-((4-((s)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-imidazole derivatives as activators of the glp1 receptor for the treatment of obesity
TW202304500A (en) 2021-04-21 2023-02-01 瑞士商諾華公司 Glucagon like peptide compounds
AU2022278933A1 (en) * 2021-05-21 2023-12-07 Yuhan Corporation Composition for preventing or treating non-alcoholic fatty liver disease or non-alcoholic steatohepatitis comprising growth differentiation factor-15 variant
EP4359539A1 (en) 2021-06-23 2024-05-01 University Of Massachusetts Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
CA3231700A1 (en) * 2021-09-10 2023-03-16 Guardian Therapeutics, Llc Fatty acid conjugates of nucleic acids
CN113582832B (en) * 2021-09-13 2024-01-26 深圳瑞德林生物技术有限公司 Preparation method of long-chain diacid
TW202342014A (en) 2022-02-10 2023-11-01 瑞士商諾華公司 1,3-benzodioxole derivatives
WO2023154953A1 (en) 2022-02-14 2023-08-17 Ngm Biopharmaceuticals, Inc. Gdf15 polypeptides for treating and preventing autoimmune diseases
CN114740105B (en) * 2022-03-17 2023-11-07 重庆医药高等专科学校 Liquid chromatographic separation detection method for proline and N-methyl proline and application thereof
WO2023196754A2 (en) * 2022-04-08 2023-10-12 University Of North Texas Health Science Center At Fort Worth Treatment for reducing or preventing tissue fibrosis
CN114891086B (en) * 2022-06-01 2024-03-26 恺佧生物科技(上海)有限公司 Renaturation method of biotin-marked GDF15
WO2024030367A2 (en) * 2022-08-01 2024-02-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fatty acid-d-amino acid peptides conjugates as anaplerotic compounds for use in treating propionic acidemia, methylmalonic acidurias, and energy metabolic disorders
CN116466010B (en) * 2023-06-15 2023-08-25 四川普锐特药业有限公司 Method for quantitatively detecting multiple lipid components in lipid nanoparticle

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3043871A (en) * 1956-09-03 1962-07-10 Ruhrchemie Ag Production of heptadecanedicarboxylic acid-1, 17
WO1983004412A1 (en) 1982-06-11 1983-12-22 National Research Development Corporation Amphipathic compounds
US4517105A (en) 1983-03-07 1985-05-14 Aluminum Company Of America Metalworking lubricant composition containing a novel substituted malonic acid diester
US4582927A (en) 1984-04-04 1986-04-15 Frito-Lay, Inc. Synthetic cooking oils containing dicarboxylic acid esters
US5175191A (en) 1988-11-14 1992-12-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
EP0492628B1 (en) 1990-12-26 1996-07-03 Ricoh Company, Ltd Reversible thermosensitive coloring composition, recording medium, recording method and image display apparatus using the recording medium
US5994102A (en) 1994-12-15 1999-11-30 Human Genome Sciences, Inc. Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
WO1996018730A1 (en) 1994-12-15 1996-06-20 Human Genome Sciences, Inc. Prostatic growth factor
US6521227B1 (en) 1999-11-18 2003-02-18 Peter L. Hudson Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
FR2735131B1 (en) 1995-06-12 1997-08-22 Rech De Pathologie Appliquee S CONJUGATES OF MSH WITH A FATTY ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
DE69637844D1 (en) 1995-06-22 2009-04-09 St Vincent S Hospital Sidney L NEW TGF-BETA-SIMILAR CYTOKIN
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
NZ334592A (en) 1996-09-11 2000-10-27 Ortho Mcneil Pharm Inc Protein growth factor related to TNF-beta and coupled with a toxic moiety for use in treating prostate cancer
AU8591198A (en) 1997-07-31 1999-02-22 Johns Hopkins University School Of Medicine, The Growth differentiation factor-15
ATE383424T1 (en) 1997-12-24 2008-01-15 Takeda Pharmaceutical POLYPEPTIDES, THEIR PRODUCTION AND USE
US6974684B2 (en) 2001-08-08 2005-12-13 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6297400B1 (en) 1999-07-02 2001-10-02 The Clorox Company Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol
AU2001247899A1 (en) 2000-04-06 2001-10-23 Genetics Institute, Llc Polynucleotides encoding novel secreted proteins
ES2300325T3 (en) 2000-04-20 2008-06-16 St Vincent's Hospital Sydney Limited DIAGNOSTIC TEST THAT IMPLIES THE CYTOKIN 1 MACROFAGOS INHIBITORY (MC1).
JP2005502322A (en) 2001-04-19 2005-01-27 ザ スクリップス リサーチ インスティテュート In vivo incorporation of unnatural amino acids
US20030166903A1 (en) 2001-04-27 2003-09-04 Anna Astromoff Genes associated with vascular disease
PT1441589E (en) 2001-11-08 2012-08-13 Abbott Biotherapeutics Corp Stable liquid pharmaceutical formulation of igg antibodies
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US7157235B2 (en) 2002-06-17 2007-01-02 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
CA2525764C (en) 2003-05-20 2012-07-17 Novartis Ag N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors
EP2932981B1 (en) 2003-09-19 2021-06-16 Novo Nordisk A/S Albumin-binding derivatives of GLP-1
JP2007522803A (en) 2004-01-14 2007-08-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Methods of using peroxisome proliferator activated receptor alpha target genes
EP2774620A1 (en) 2004-04-13 2014-09-10 St Vincent's Hospital Sydney Limited Method for modulating weight loss
WO2005099747A1 (en) 2004-04-14 2005-10-27 Medical Research Council Selective killing of cancer cells by induction of acetyltransferase via tnf-alpha and il-6
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
US20090142338A1 (en) * 2005-03-04 2009-06-04 Curedm, Inc. Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions
JP5164830B2 (en) 2005-04-29 2013-03-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム A novel method for the prevention or treatment of Mycobacterium tuberculosis infection
US20110319324A1 (en) 2005-05-27 2011-12-29 Five Prime Therapeutics, Inc. Methods of and compositions for stimulation of glucose uptake into muscle cells and treatment of diseases
US8673848B2 (en) 2012-01-27 2014-03-18 Novartis Ag Synthetic apelin mimetics for the treatment of heart failure
JP2009517412A (en) 2005-11-30 2009-04-30 アンブリリア バイオファーマ インコーポレイテッド Lysine-based prodrugs of aspartyl protease inhibitors and methods for their preparation
AR058567A1 (en) 2005-12-20 2008-02-13 Bristol Myers Squibb Co FORMULATIONS OF STABLE PROTEINS
CN101002945B (en) 2006-01-20 2012-09-05 清华大学 Novel complex used for treating tumor
CN101854947A (en) 2007-08-16 2010-10-06 圣文森特医院悉尼有限公司 Be used to regulate active medicament of macrophage inhibition factor (MIC-1) and method
US20100310504A1 (en) 2007-09-26 2010-12-09 Lowe Scott W Methods for treating fibrosis by modulating cellular senescence
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
MX2010010743A (en) 2008-03-31 2010-11-04 Ferring Bv Oxytocin analogues.
CN102264697B (en) 2008-10-24 2015-09-09 Irm责任有限公司 Pyrroline-carboxy-Methionin that biosynthesizing produces and protein modified by the locus specificity of pyrroline-carboxy-Methionin and pyrrolysine residue chemical derivatization
JP2012507487A (en) * 2008-11-05 2012-03-29 エフ．ホフマン−ラ ロシュ アーゲー Neuropeptide 2 receptor (Y-2R) agonists and uses thereof
EP2211182A1 (en) 2009-01-16 2010-07-28 Roche Diagnostics GmbH Method for the assessment of severity of liver cirrhosis
EP2209003A1 (en) 2009-01-16 2010-07-21 F. Hoffmann-Roche AG Means and methods for differentiating between fibrosis and cirrhosis
EP2261662B1 (en) * 2009-06-10 2014-01-22 Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften Novel synthetic blocking reagents
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
WO2011085000A2 (en) 2010-01-06 2011-07-14 The University Of North Carolina At Chapel Hill Fatty acid derivatives and analogs of drugs
CN101852804B (en) 2010-03-29 2013-06-12 中国医学科学院病原生物学研究所 New applications of antibody of GDF15 (Growth differentiation factor 15) protein
CN103153927B (en) 2010-04-27 2017-02-15 西纳福克斯股份有限公司 Fused cyclooctyne compounds and their use in metal-free click reactions
US9238080B2 (en) 2010-05-21 2016-01-19 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins
GB201018518D0 (en) 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
CN103533951B (en) * 2011-04-08 2017-04-19 安姆根有限公司 Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
WO2012140647A2 (en) 2011-04-11 2012-10-18 Yeda Research And Development Co. Ltd Albumin binding probes and drug conjugates thereof
US9394343B2 (en) 2011-07-05 2016-07-19 The Regents Of The University Of California Appetite stimulating protein
WO2013027191A1 (en) 2011-08-25 2013-02-28 Novartis Ag Methods and compositions using fgf23 fusion polypeptides
US9714276B2 (en) 2012-01-26 2017-07-25 Amgen Inc. Growth differentiation factor 15 (GDF-15) polypeptides
WO2013130684A1 (en) 2012-02-27 2013-09-06 Amunix Operating Inc. Xten-folate conjugate compositions and methods of making same
WO2013148117A1 (en) 2012-03-27 2013-10-03 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
US8921307B2 (en) 2012-11-20 2014-12-30 Novartis Ag Synthetic linear apelin mimetics for the treatment of heart failure
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
ES2732574T3 (en) 2012-11-30 2019-11-25 Novartis Ag Methods for preparing conjugates from proteins containing disulfide
DK2934584T3 (en) 2012-12-21 2020-05-18 Aveo Pharmaceuticals Inc ANTI-GDF15 ANTIBODIES
LT2935312T (en) 2012-12-21 2018-10-25 F. Hoffmann-La Roche Ag Peptides as oxytocin agonists
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
EP2950807B1 (en) 2013-01-30 2018-03-28 NGM Biopharmaceuticals, Inc. Compositions and methods of use in treating metabolic disorders
SG10201913751RA (en) 2013-05-06 2020-03-30 Scholar Rock Inc Compositions and methods for growth factor modulation
MX2016000220A (en) 2013-07-03 2016-08-18 Alder Biopharmaceuticals Inc Regulation of glucose metabolism using anti-cgrp antibodies.
EP3613755A1 (en) 2013-07-11 2020-02-26 Novartis AG Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase
US9683018B2 (en) 2013-07-25 2017-06-20 Novartis Ag Disulfide cyclic polypeptides for the treatment of heart failure
US9908919B2 (en) 2013-07-25 2018-03-06 Novartis Ag Cyclic apelin derivatives for the treatment of heart failure
UY35670A (en) 2013-07-25 2015-02-27 Novartis Ag CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
BR112016001376A2 (en) 2013-07-25 2017-10-24 Novartis Ag synthetic apelin polypeptide bioconjugates
EA202092386A1 (en) 2013-07-31 2021-04-30 Эмджен Инк. CONSTRUCTIONS BASED ON DIFFERENTIATION AND GROWTH FACTOR 15 (GDF15)
AU2014356126B2 (en) 2013-11-26 2017-01-05 Novartis Ag Methods for oxime conjugation to ketone-modified polypeptides
CA2938592A1 (en) 2014-02-07 2015-08-13 Effector Therapeutics, Inc. Methods for treating fibrotic disease
CN106461830B (en) 2014-05-01 2019-08-27 富士胶片株式会社 Infrared sensor, near-infrared absorbing composition, photosensitive polymer combination, compound and its application
EP3139957A4 (en) 2014-05-06 2018-04-25 Scholar Rock, Inc. Compositions and methods for growth factor modulation
US10406198B2 (en) 2014-05-23 2019-09-10 Novartis Ag Methods for making conjugates from disulfide-containing proteins
EP3157953B1 (en) 2014-06-20 2021-12-22 Aveo Pharmaceuticals, Inc. Treatment of chronic kidney disease and other renal dysfunction using a gdf15 modulator
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2015200080A1 (en) 2014-06-23 2015-12-30 Novartis Ag Site specific protein modifications
US20170204149A1 (en) 2014-06-23 2017-07-20 Novartis Ag Hsa-gdf-15 fusion polypeptide and use thereof
US9272019B2 (en) 2014-06-24 2016-03-01 Novo Nordisk A/S MIC-1 fusion proteins and uses thereof
KR20170065026A (en) 2014-07-30 2017-06-12 엔지엠 바이오파마슈티컬스, 아이엔씨. Compositions and methods of use for treating metabolic disorders
WO2016069925A1 (en) 2014-10-30 2016-05-06 Acceleron Pharma Inc. Methods and compositions using gdf15 polypeptides for increasing red blood cells
CA2961587A1 (en) 2014-10-31 2016-05-06 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
CN107108754A (en) 2014-12-22 2017-08-29 诺和诺德股份有限公司 The antitrypsins of α 1 (A1AT) fusion protein and application thereof
MX2017009534A (en) 2015-01-23 2018-04-10 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life.
AU2016246708B2 (en) 2015-04-06 2020-12-24 Acceleron Pharma Inc. ALK7:actRIIB heteromultimers and uses thereof
PL3280727T3 (en) 2015-04-06 2021-07-19 Acceleron Pharma Inc. Single-arm type i and type ii receptor fusion proteins and uses thereof
MA41919A (en) 2015-04-06 2018-02-13 Acceleron Pharma Inc ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES
WO2017066525A1 (en) 2015-10-14 2017-04-20 The Johns Hopkins University Protein bioconjugation method
US20190000923A1 (en) 2015-12-22 2019-01-03 Novartis Ag Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
EP3184106A1 (en) 2015-12-23 2017-06-28 Sanofi-Aventis Deutschland GmbH Growth differentiation factor 15 as biomarker for metformin
US11105818B2 (en) 2016-01-15 2021-08-31 Novo Nordisk A/S MIC-1 receptor and uses thereof
CN108697795A (en) 2016-02-29 2018-10-23 伊莱利利公司 Gfral receptor therapies
EP3423097A4 (en) 2016-03-04 2019-08-21 NGM Biopharmaceuticals, Inc. Compositions and methods for modulating body weight
KR101727506B1 (en) 2016-07-14 2017-05-04 충남대학교 산학협력단 Pharmaceutical composition for the prevention or treatment of fat liver comprising GDF15 protein or polynucleotide encoding GDF15 as an effective ingredient
MA50141A (en) 2017-04-20 2020-07-29 Novo Nordisk As ALBUMIN FUSION PROTEIN PURIFICATION PROCESSES
TWI710377B (en) 2017-05-23 2020-11-21 丹麥商諾佛 儂迪克股份有限公司 Mic-1 compounds and uses thereof
WO2019048660A1 (en) 2017-09-10 2019-03-14 Novo Nordisk A/S Mic-1 and glp-1 for use in the treatment of obesity
EP3934679A1 (en) 2019-03-08 2022-01-12 Amgen Inc. Growth differentiation factor 15 combination therapy
EP4041281A1 (en) 2019-10-04 2022-08-17 Amgen Inc. Use of gdf15 for treating cardiometabolic syndrome and other conditions
CN116925237A (en) 2019-12-31 2023-10-24 北京质肽生物医药科技有限公司 Fusion proteins of GLP-1 and GDF15 and conjugates thereof
BR112022020809A2 (en) 2020-04-15 2023-02-23 Theradaptive Inc COMPOSITIONS AND METHODS FOR BONE-DIRECTED THERAPEUTIC DELIVERY
WO2022092915A1 (en) 2020-10-30 2022-05-05 가톨릭대학교 산학협력단 Composition for preventing and treating immune diseases containing gdf15 as active ingredient

Also Published As

Publication number Publication date
MA40278A (en) 2017-04-26
MY193993A (en) 2022-11-07
PL3157571T3 (en) 2022-03-28
TWI750725B (en) 2021-12-21
ECSP17004665A (en) 2018-11-30
JO3813B1 (en) 2021-01-31
JP2019206563A (en) 2019-12-05
HK1232160A1 (en) 2018-01-05
RS62907B1 (en) 2022-03-31
JP7051959B2 (en) 2022-04-11
HUE057845T2 (en) 2022-06-28
TWI701048B (en) 2020-08-11
CN107073130B (en) 2021-11-16
UY36186A (en) 2016-01-29
WO2015200078A8 (en) 2016-04-14
LT3157571T (en) 2022-02-25
JP2017519024A (en) 2017-07-13
EP3157571A1 (en) 2017-04-26
HRP20220152T1 (en) 2022-04-15
TW202204384A (en) 2022-02-01
CN114099693A (en) 2022-03-01
KR20230056796A (en) 2023-04-27
CY1125006T1 (en) 2023-01-05
AU2015280351C1 (en) 2022-11-24
KR20170020878A (en) 2017-02-24
SG11201609704TA (en) 2017-01-27
CA2953480A1 (en) 2015-12-30
BR112016028884A2 (en) 2017-10-31
JP2020203934A (en) 2020-12-24
TN2016000558A1 (en) 2018-04-04
JP2022095757A (en) 2022-06-28
GT201600263A (en) 2019-07-19
EA201692466A1 (en) 2017-04-28
EP3988170A1 (en) 2022-04-27
US11752211B2 (en) 2023-09-12
CR20160596A (en) 2017-05-08
EA039074B1 (en) 2021-11-30
PH12016502294A1 (en) 2017-02-13
AU2015280351A1 (en) 2016-12-08
CU20160189A7 (en) 2017-04-05
CU24455B1 (en) 2019-11-04
KR102559975B1 (en) 2023-07-27
AP2016009585A0 (en) 2016-11-30
TW201613653A (en) 2016-04-16
US20180326079A1 (en) 2018-11-15
MX2016017395A (en) 2017-05-01
CN107073130A (en) 2017-08-18
TW202039004A (en) 2020-11-01
AU2015280351B2 (en) 2018-07-05
CN114133443A (en) 2022-03-04
MX367520B (en) 2019-08-26
EP3157571B1 (en) 2021-11-24
WO2015200078A1 (en) 2015-12-30
JP2023099133A (en) 2023-07-11
US20240066132A1 (en) 2024-02-29
JP6823696B2 (en) 2021-02-03
IL248990B (en) 2019-09-26
US20210000964A1 (en) 2021-01-07
US10786576B2 (en) 2020-09-29
SI3157571T1 (en) 2022-04-29
TWI792596B (en) 2023-02-11
ES2905479T3 (en) 2022-04-08
CL2016003281A1 (en) 2017-06-09
JP6636959B2 (en) 2020-01-29
US20160030585A1 (en) 2016-02-04
SG10201912965TA (en) 2020-02-27
PH12016502294B1 (en) 2017-02-13
US10588980B2 (en) 2020-03-17
DK3157571T3 (en) 2022-02-21
PT3157571T (en) 2022-02-14
IL248990A0 (en) 2017-01-31

Similar Documents

Publication Publication Date Title
PE20171095A1 (en) NOVEL FATTY ACIDS AND THEIR USE IN CONJUGATION WITH BIOMOLECULES
CL2010000935A1 (en) Compounds derived from niacin linked to a fatty acid; pharmaceutical composition that includes them; and its use to treat a metabolic disease such as hypertriglyceridemia, hypercholesterolemia, type 2 diabetes and diabetic retinopathy.
ES2620456T3 (en) Polysaccharide derivatives of lipoic acid, its preparation, use as cosmetic products for the skin and medical medical devices
CY1120413T1 (en) SPECIALLY HUMANIZED ANTIBODIES IN THE PROTEINOLOGICAL FORM OF BETA-AMYLOID Peptide
ECSP12011631A (en) PROLONGED INSULIN COMPOSITION
CL2015003690A1 (en) Use of pridopidine or a salt thereof to prepare a medication useful in the treatment of huntington's disease.
CL2015003117A1 (en) Crystal structure modifications
CO6751287A2 (en) Mycobacterial antigenic composition
UA113165C2 (en) APPLICATION OF A COMBINATION OF Baclofen AND ACOMPROSAT FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND A COMPOSITION CONTAINING Baclofen AND ACAMPROSAT
DOP2013000130A (en) PIRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS THROUGH LP - PLA2
AR077764A1 (en) SELECTIVE POLYPEPTIDES FOR INTEGRINE ALFAVBETA 3 CONJUGATED TO A HUMAN SEROALBUMIN VARIANTE (HSA) AND PHARMACEUTICAL USES OF THE SAME
CL2009000309A1 (en) Aromatic fluoroglycoside derivatives, pharmaceutical composition containing these compounds, procedure to prepare it and its use in the treatment of type 1 and type 2 diabetes.
BR112014005025A2 (en) pharmaceutical composition for use in the treatment of a neurodegenerative disease
PE20091007A1 (en) CYCLIC DEPSIPEPTIDES AS CALICREIN MODULATORS 7
EA201690005A1 (en) COMPOSITION WITH MODIFIED EXTRUSION KINETICS
CL2011002617A1 (en) Compounds derived from 2,5-disubstituted arylsulfonamides, ccr3 receptor modulators; pharmaceutical composition that includes them; and use of the compound or composition to prevent and / or treat an inflammatory or immunoregulatory disorder such as asthma, rhinitis, hiv, Alzheimer's disease, among others.
EA201790223A1 (en) WATER PREPARATION CONTAINING PARACETAMOL AND IBUPROFEN
CO6400226A2 (en) ANTI-INFLAMMATORY MICROLID
CL2010001577A1 (en) Use of nifurtimox to prepare a useful medicine in the treatment of diseases caused by giardias.
BR112012004916A2 (en) stable sns-595 compositions and preparation methods
BR112013028607A2 (en) solid compositions containing glycolic ether and water
CL2009000478A1 (en) Pharmaceutical composition comprising piracetam or a salt thereof, l-carnitine and a vehicle; composition preparation process; and its use for the treatment and / or prevention of mitochondrial disorders related to side effects induced by drugs, such as Alzheimer's disease or Parkinson's disease.
AR076910A1 (en) A COSMETIC DEPIGMENTATION AGENT UNDERSTANDING A DELTA -TOCOPHERILE CARBOHYDRATE
UY36098A (en) COMPOSITE 1,1? -ADIPOYLBIS (PIRROLIDINE-2-CARBOXYLATE) OF (2R, 2? R) -BIS ((((((TETRAHIDRO-2H-PIRAN-4- IL) OXI) CARBONIL) OXI) METHYL), FOR TREATMENT OF SYSTEMIC AMYLOIDOSIS.
PE20141549A1 (en) MATURE CRIG VARIANTS BY AFFINITY