PE20140873A1 - Antagonistas no competitivos de receptores nicotinicos - Google Patents

Antagonistas no competitivos de receptores nicotinicos

Info

Publication number
PE20140873A1
PE20140873A1 PE2013001526A PE2013001526A PE20140873A1 PE 20140873 A1 PE20140873 A1 PE 20140873A1 PE 2013001526 A PE2013001526 A PE 2013001526A PE 2013001526 A PE2013001526 A PE 2013001526A PE 20140873 A1 PE20140873 A1 PE 20140873A1
Authority
PE
Peru
Prior art keywords
individually
competitive antagonists
nicotine receptors
receptors non
halogen
Prior art date
Application number
PE2013001526A
Other languages
English (en)
Inventor
Srinivasa Rao Akireddy
Scott R Breining
Matt S Melvin
Srinivasa V Murthy
Anatoly A Mazurov
Balwinder Singh Bhatti
Jon-Paul Strachan
Ronald Josseph Heemstra
Todd Showalter
Yunde Xiao
Philip S Hammond
Lan Miao
David Kombo
Daniel Yohannes
Jason Speake
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PE20140873A1 publication Critical patent/PE20140873A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 Y R2 SON INDIVIDUALMENTE H, ALQUILO C1-6, O R1 Y R2 SE COMBINAN CON NITROGENO AL QUE SE UNEN PARA FORMAR UN ANILLO DE 3 A 8 MIEMBROS EL CUAL PUEDE ESTAR OPCIONALMENTE SUSTITUIDO; R15 Y R16 ES INDIVIDUALMENTE H, HALOGENO, HIDROXILO, ALCOXI C1-6, ENTRE OTROS; R3 ES H O ALQUILO C1-6; X11, X12, X13, Y X14 ES INDIVIDUALMENTE -(CR4R5)-, DONDE R4 Y R5 ES INDIVIDUALMENTE H, HALOGENO, ARILOXI C6-14, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE HIPERTENSION, ADICCION A LA NICOTINA, DEPRESION O ANSIEDAD
PE2013001526A 2011-01-07 2012-01-05 Antagonistas no competitivos de receptores nicotinicos PE20140873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161430640P 2011-01-07 2011-01-07

Publications (1)

Publication Number Publication Date
PE20140873A1 true PE20140873A1 (es) 2014-08-13

Family

ID=46457959

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013001526A PE20140873A1 (es) 2011-01-07 2012-01-05 Antagonistas no competitivos de receptores nicotinicos

Country Status (15)

Country Link
US (1) US20140288169A1 (es)
EP (1) EP2661421A2 (es)
JP (1) JP2014510026A (es)
KR (1) KR20140038361A (es)
CN (1) CN103402971A (es)
BR (1) BR112013017405A2 (es)
CA (1) CA2823848A1 (es)
CL (1) CL2013001978A1 (es)
CO (1) CO6821933A2 (es)
IL (2) IL227319A0 (es)
MX (1) MX2013007952A (es)
PE (1) PE20140873A1 (es)
RU (1) RU2013136851A (es)
SG (1) SG191884A1 (es)
WO (1) WO2012094437A2 (es)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514486A (en) * 1968-05-23 1970-05-26 Miles Lab 3-isopropylnorbornanamine
US4883888A (en) * 1984-07-13 1989-11-28 The Procter & Gamble Company Oxa-fenchyl amines useful for preparing high intensity sweeteners
DE69524223T2 (de) * 1994-07-11 2002-08-22 Allergan Sales Inc Bicyclische derivate mit starrer konformation und adamantane als alpha-2-adrenergische blockierende agenzien
US5986142A (en) * 1997-09-23 1999-11-16 Poli Industria Chimica Spa Process for preparing bicycloheptanamine compounds
AU2002326806B2 (en) * 2001-08-29 2007-07-19 Endo Pharmaceuticals, Inc. Analgetic pyrroline derivatives
US20080058345A1 (en) * 2004-01-06 2008-03-06 Tony George Combination Therapy with Mecamylamine for the Treatment of Mood Disorders
EP1753429A1 (en) * 2004-05-28 2007-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7880007B2 (en) * 2004-11-29 2011-02-01 Vertex Pharmaceuticals Incorporated Bicyclic substituted phenyl piperidine modulators of muscarinic receptors
WO2006105035A2 (en) * 2005-03-28 2006-10-05 Vertex Pharmaceuticals Incorporated Muscarinic modulators
JPWO2006104280A1 (ja) * 2005-03-31 2008-09-11 武田薬品工業株式会社 糖尿病の予防・治療剤
MX2008000115A (es) * 2005-06-20 2008-03-18 Schering Corp Derivados de piperidina utiles como antagonistas de histamina h3.
PL1937248T3 (pl) * 2005-09-17 2010-11-30 Novartis Ag Amidy kwasów alkanowych podstawione nasyconymi grupami O-heterocyklicznymi
CA2632582A1 (en) * 2005-12-20 2007-06-28 Solvay Pharmaceuticals B.V. 4,5-dihydro- (1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
TW200730500A (en) * 2005-12-20 2007-08-16 Solvay Pharm Bv 4, 5-dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators
AU2008256803A1 (en) * 2007-05-24 2008-12-04 Wyeth Azacyclylbenzamide derivatives as histamine-3 antagonists
WO2009146031A1 (en) * 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
CA2761157A1 (en) * 2009-05-29 2010-12-02 Xlterra, Inc. Ketal esters of anhydropentitols and uses thereof
WO2013026852A2 (en) * 2011-08-22 2013-02-28 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Derivatives of mecamylamine

Also Published As

Publication number Publication date
CA2823848A1 (en) 2012-07-12
CN103402971A (zh) 2013-11-20
BR112013017405A2 (pt) 2016-10-04
CL2013001978A1 (es) 2013-11-04
JP2014510026A (ja) 2014-04-24
WO2012094437A2 (en) 2012-07-12
IL227319A0 (en) 2013-09-30
RU2013136851A (ru) 2015-02-20
KR20140038361A (ko) 2014-03-28
MX2013007952A (es) 2013-08-21
IL230334A0 (en) 2014-03-06
CO6821933A2 (es) 2013-12-31
SG191884A1 (en) 2013-08-30
US20140288169A1 (en) 2014-09-25
WO2012094437A3 (en) 2012-11-01
EP2661421A2 (en) 2013-11-13

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal