PE20121643A1 - Polipeptidos del factor ix modificados y usos de los mismos - Google Patents
Polipeptidos del factor ix modificados y usos de los mismosInfo
- Publication number
- PE20121643A1 PE20121643A1 PE2012000114A PE2012000114A PE20121643A1 PE 20121643 A1 PE20121643 A1 PE 20121643A1 PE 2012000114 A PE2012000114 A PE 2012000114A PE 2012000114 A PE2012000114 A PE 2012000114A PE 20121643 A1 PE20121643 A1 PE 20121643A1
- Authority
- PE
- Peru
- Prior art keywords
- polypeptide
- remains
- factor
- polypeptides
- conjugate
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 229960004222 factor ix Drugs 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23055109P | 2009-07-31 | 2009-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121643A1 true PE20121643A1 (es) | 2012-11-25 |
Family
ID=43529743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000114A PE20121643A1 (es) | 2009-07-31 | 2010-08-02 | Polipeptidos del factor ix modificados y usos de los mismos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20120164130A1 (forum.php) |
| EP (1) | EP2461821A4 (forum.php) |
| JP (1) | JP2013500726A (forum.php) |
| KR (1) | KR20120060209A (forum.php) |
| CN (1) | CN102573890A (forum.php) |
| AU (1) | AU2010278721A1 (forum.php) |
| BR (1) | BR112012002072A2 (forum.php) |
| CA (1) | CA2769258A1 (forum.php) |
| CL (1) | CL2012000238A1 (forum.php) |
| CR (1) | CR20120052A (forum.php) |
| CU (3) | CU20120018A7 (forum.php) |
| DO (1) | DOP2012000030A (forum.php) |
| EA (1) | EA201290069A1 (forum.php) |
| EC (1) | ECSP12011637A (forum.php) |
| GT (1) | GT201200023A (forum.php) |
| IN (1) | IN2012DN00908A (forum.php) |
| MX (1) | MX2012001346A (forum.php) |
| PE (1) | PE20121643A1 (forum.php) |
| SG (1) | SG178119A1 (forum.php) |
| WO (1) | WO2011014890A1 (forum.php) |
| ZA (1) | ZA201200716B (forum.php) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| USRE50288E1 (en) | 2008-09-15 | 2025-02-04 | Uniqure Biopharma B.V. | Factor IX polypeptide mutant, its uses and a method for its production |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| NZ598056A (en) | 2009-07-27 | 2014-01-31 | Baxter Int | Blood coagulation protein conjugates |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| RU2533619C2 (ru) | 2009-07-27 | 2014-11-20 | Лайпоксен Текнолоджиз Лимитед | Гликополисиалирование белков, не являющихся белками свертывания крови |
| ES2856055T3 (es) | 2009-07-27 | 2021-09-27 | Baxalta GmbH | Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre |
| NZ605972A (en) * | 2010-07-30 | 2015-04-24 | Baxter Healthcare Sa | Nucleophilic catalysts for oxime linkage |
| JP6138052B2 (ja) | 2010-12-22 | 2017-05-31 | バクスアルタ ゲーエムベーハー | 水溶性脂肪酸誘導体をタンパク質に抱合させるための材料および方法 |
| CA2856492C (en) * | 2011-12-19 | 2017-01-10 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
| WO2014081831A1 (en) * | 2012-11-20 | 2014-05-30 | The University Of North Carolina At Chapel Hill | Methods and compositions for modified factor ix proteins |
| WO2014165189A2 (en) * | 2013-03-13 | 2014-10-09 | Eli Lilly And Company | Modified canine leptin polypeptides |
| TW201519900A (zh) * | 2013-04-28 | 2015-06-01 | Bayer Healthcare Llc | 用於誘導對凝血因子蛋白之免疫耐受性的組成物及方法 |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| IL257231B (en) | 2015-08-03 | 2022-09-01 | Bioverativ Therapeutics Inc | Factor ix fusion proteins and methods of making and using same |
| EP3490586B1 (en) | 2016-07-27 | 2025-03-26 | The Children's Hospital of Philadelphia | Compositions and methods for modulating factor ix function |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| CN113260701A (zh) | 2018-10-18 | 2021-08-13 | 英特利亚治疗股份有限公司 | 用于表达因子ix的组合物和方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002254731A1 (en) * | 2001-04-25 | 2002-11-05 | The Regents Of The University Of California | Method to treat hemophilia by hepatic gene transfer of factor viii/ix with vesicle vector |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| JP4738346B2 (ja) * | 2003-12-03 | 2011-08-03 | ノヴォ ノルディスク アー／エス | ＧｌｙｃｏＰＥＧ化された第ＩＸ因子 |
| EP2423306A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US7700734B2 (en) * | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
-
2010
- 2010-08-02 EP EP10805185.5A patent/EP2461821A4/en not_active Withdrawn
- 2010-08-02 CA CA2769258A patent/CA2769258A1/en not_active Abandoned
- 2010-08-02 US US13/388,288 patent/US20120164130A1/en not_active Abandoned
- 2010-08-02 EA EA201290069A patent/EA201290069A1/ru unknown
- 2010-08-02 JP JP2012523129A patent/JP2013500726A/ja active Pending
- 2010-08-02 BR BR112012002072A patent/BR112012002072A2/pt not_active IP Right Cessation
- 2010-08-02 IN IN908DEN2012 patent/IN2012DN00908A/en unknown
- 2010-08-02 PE PE2012000114A patent/PE20121643A1/es not_active Application Discontinuation
- 2010-08-02 WO PCT/US2010/044177 patent/WO2011014890A1/en not_active Ceased
- 2010-08-02 AU AU2010278721A patent/AU2010278721A1/en not_active Abandoned
- 2010-08-02 MX MX2012001346A patent/MX2012001346A/es not_active Application Discontinuation
- 2010-08-02 KR KR1020127005191A patent/KR20120060209A/ko not_active Withdrawn
- 2010-08-02 SG SG2012005757A patent/SG178119A1/en unknown
- 2010-08-02 CN CN2010800431356A patent/CN102573890A/zh active Pending
-
2012
- 2012-01-27 DO DO2012000030A patent/DOP2012000030A/es unknown
- 2012-01-30 CU CU20120018A patent/CU20120018A7/es unknown
- 2012-01-30 CR CR20120052A patent/CR20120052A/es unknown
- 2012-01-30 ZA ZA2012/00716A patent/ZA201200716B/en unknown
- 2012-01-30 EC EC2012011637A patent/ECSP12011637A/es unknown
- 2012-01-30 CL CL2012000238A patent/CL2012000238A1/es unknown
- 2012-01-30 GT GT201200023A patent/GT201200023A/es unknown
-
2013
- 2013-04-19 CU CU2013000057A patent/CU20130057A7/es unknown
- 2013-04-19 CU CU2013000058A patent/CU20130058A7/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2012DN00908A (forum.php) | 2015-04-03 |
| CL2012000238A1 (es) | 2012-10-05 |
| ECSP12011637A (es) | 2012-02-29 |
| CN102573890A (zh) | 2012-07-11 |
| US20120164130A1 (en) | 2012-06-28 |
| CU20130057A7 (es) | 2013-06-28 |
| BR112012002072A2 (pt) | 2016-11-08 |
| CU20130058A7 (es) | 2013-06-28 |
| GT201200023A (es) | 2014-01-27 |
| JP2013500726A (ja) | 2013-01-10 |
| SG178119A1 (en) | 2012-03-29 |
| EA201290069A1 (ru) | 2012-07-30 |
| WO2011014890A1 (en) | 2011-02-03 |
| AU2010278721A1 (en) | 2012-02-16 |
| CA2769258A1 (en) | 2011-02-03 |
| CU20120018A7 (es) | 2012-06-21 |
| KR20120060209A (ko) | 2012-06-11 |
| ZA201200716B (en) | 2013-07-31 |
| CR20120052A (es) | 2012-06-04 |
| DOP2012000030A (es) | 2012-02-29 |
| EP2461821A4 (en) | 2013-07-03 |
| EP2461821A1 (en) | 2012-06-13 |
| MX2012001346A (es) | 2012-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |