PE20120368A1 - Pirrolopirimidindiona dimerica - Google Patents

Pirrolopirimidindiona dimerica

Info

Publication number
PE20120368A1
PE20120368A1 PE2011001417A PE2011001417A PE20120368A1 PE 20120368 A1 PE20120368 A1 PE 20120368A1 PE 2011001417 A PE2011001417 A PE 2011001417A PE 2011001417 A PE2011001417 A PE 2011001417A PE 20120368 A1 PE20120368 A1 PE 20120368A1
Authority
PE
Peru
Prior art keywords
refers
formula
pyrrolopyrimidindiona
dimerica
compound
Prior art date
Application number
PE2011001417A
Other languages
English (en)
Inventor
Christine Edwards
Janus Kulagowski
Harry Finch
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42026259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120368(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0901616A external-priority patent/GB0901616D0/en
Priority claimed from GB0908068A external-priority patent/GB0908068D0/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20120368A1 publication Critical patent/PE20120368A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DERIVADO DE 3,4,6,7-TETRAHIDRO-1H-PIRROLO[3,4-d]PIRIMIDIN-2,5-DIONA SUSTITUIDA DE FORMULA (I) EN DONDE LA ESTEREOCONFIGURACION R-R QUE SE MUESTRA EN LA FORMULA (IA) PREDOMINA SOBRE LA CONFIGURACION R-S Y S-S. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA ELASTASA DEL NEUTROFILO HUMANO (HNE) SIENDO UTIL EN EL TRATAMIENTO DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, FIBROSIS QUISTICA, ENFISEMA PULMONAR, NEUMONIA
PE2011001417A 2009-01-30 2010-01-22 Pirrolopirimidindiona dimerica PE20120368A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0901616A GB0901616D0 (en) 2009-01-30 2009-01-30 Enzyme inhibitors
GB0908068A GB0908068D0 (en) 2009-05-11 2009-05-11 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
PE20120368A1 true PE20120368A1 (es) 2012-05-04

Family

ID=42026259

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001417A PE20120368A1 (es) 2009-01-30 2010-01-22 Pirrolopirimidindiona dimerica

Country Status (19)

Country Link
US (1) US8455505B2 (es)
EP (1) EP2391629B1 (es)
JP (1) JP2012516316A (es)
KR (1) KR20110124217A (es)
CN (1) CN102300865B (es)
AU (1) AU2010209456A1 (es)
BR (1) BRPI1005684A2 (es)
CA (1) CA2751054A1 (es)
CL (1) CL2011001838A1 (es)
CO (1) CO6420348A2 (es)
EA (1) EA201190087A1 (es)
ES (1) ES2399908T3 (es)
IL (1) IL214353A0 (es)
MA (1) MA33070B1 (es)
MX (1) MX2011007697A (es)
PE (1) PE20120368A1 (es)
SG (1) SG173463A1 (es)
TN (1) TN2011000356A1 (es)
WO (1) WO2010086638A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9657015B2 (en) * 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
GB0502258D0 (en) * 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
WO2009013444A1 (en) * 2007-07-25 2009-01-29 Argenta Discovery Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
EP2024367B1 (en) * 2006-05-04 2010-09-08 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors

Also Published As

Publication number Publication date
CN102300865B (zh) 2013-12-04
KR20110124217A (ko) 2011-11-16
JP2012516316A (ja) 2012-07-19
SG173463A1 (en) 2011-09-29
EA201190087A1 (ru) 2012-05-30
CL2011001838A1 (es) 2012-01-06
CN102300865A (zh) 2011-12-28
EP2391629A1 (en) 2011-12-07
ES2399908T3 (es) 2013-04-04
AU2010209456A1 (en) 2011-08-18
MA33070B1 (fr) 2012-02-01
MX2011007697A (es) 2011-10-12
IL214353A0 (en) 2011-09-27
US20120027692A1 (en) 2012-02-02
CA2751054A1 (en) 2010-08-05
EP2391629B1 (en) 2012-10-31
US8455505B2 (en) 2013-06-04
TN2011000356A1 (en) 2013-03-27
WO2010086638A1 (en) 2010-08-05
CO6420348A2 (es) 2012-04-16
BRPI1005684A2 (pt) 2018-06-12

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