PE20081699A1 - DERIVADOS DE HIDROXIFENILO COMO LIGANDOS SELECTIVOS DE ERß - Google Patents

DERIVADOS DE HIDROXIFENILO COMO LIGANDOS SELECTIVOS DE ERß

Info

Publication number
PE20081699A1
PE20081699A1 PE2008000221A PE2008000221A PE20081699A1 PE 20081699 A1 PE20081699 A1 PE 20081699A1 PE 2008000221 A PE2008000221 A PE 2008000221A PE 2008000221 A PE2008000221 A PE 2008000221A PE 20081699 A1 PE20081699 A1 PE 20081699A1
Authority
PE
Peru
Prior art keywords
alkyl
erß
fluoro
aryl
hydroxyphenyl
Prior art date
Application number
PE2008000221A
Other languages
English (en)
Inventor
James C Keith
George P Vlasuk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20081699A1 publication Critical patent/PE20081699A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE R1 ES H, HALOGENO, TRIFLUOROALQUILO C1-C6, TRIFLUOROALCOXI C1-C6, ENTRE OTROS; R2 Y R2a SON HIDROXILO, ALCOXI C1-C4, ALQUILO C1-C6, ALQUINILO C2-C7, ENTRE OTROS; R3, R3a Y R4 SON H, ALQUILO C1-C6, ALQUENILO C2-C7, TRIFLUOROALCOXI C1-C6, ENTRE OTROS; X ES O, S O NR7; R7 ES H, ALQUILO C1-C6, ARILO C6-C10, CO2R5, -COR5 O -SO2R5; R5 ES H, ALQUILO C1-C6 O ARILO C6-C10. SON COMPUESTOS PREFERIDOS: 2-(3-FLUORO-4-HIDROXIFENIL)-7-VINIL-1,3-BENZOXAZOL-5-OL, 3-(3-FLUORO-4-HIDROXIFENIL)-7-HIDROXI-1-NAFTONITRILO Y 2,8-DIHIDROXI-6H-DIBENZO[c,h]CROMEN-12-CARBONITRILO. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS SELECTIVOS DE LOS RECEPTORES DE ESTROGENO BETA (ERß) Y SON UTILES EN EL TRATAMIENTO DE LESIONES PULMONARES AGUDAS, TALES COMO LAS CAUSADAS POR INHALACION DE HUMO, SEPSIS O POR DEFICIT DE TENSIOACTIVO EN BEBE PREMATURO, ENTRE OTROS
PE2008000221A 2007-01-31 2008-01-30 DERIVADOS DE HIDROXIFENILO COMO LIGANDOS SELECTIVOS DE ERß PE20081699A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88740007P 2007-01-31 2007-01-31

Publications (1)

Publication Number Publication Date
PE20081699A1 true PE20081699A1 (es) 2008-12-31

Family

ID=39544985

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000221A PE20081699A1 (es) 2007-01-31 2008-01-30 DERIVADOS DE HIDROXIFENILO COMO LIGANDOS SELECTIVOS DE ERß

Country Status (13)

Country Link
US (1) US20080182872A1 (es)
EP (1) EP2112926A2 (es)
JP (1) JP2010516819A (es)
CN (1) CN101600421A (es)
AR (1) AR065104A1 (es)
AU (1) AU2008210528A1 (es)
BR (1) BRPI0807429A2 (es)
CA (1) CA2676553A1 (es)
CL (1) CL2008000308A1 (es)
MX (1) MX2009008121A (es)
PE (1) PE20081699A1 (es)
TW (1) TW200838509A (es)
WO (1) WO2008094976A2 (es)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559177B2 (en) * 2001-04-19 2003-05-06 Wyeth 5, 11-Dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents
US6589980B2 (en) * 2001-05-17 2003-07-08 Wyeth Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6903238B2 (en) * 2001-12-13 2005-06-07 Wyeth Substituted indenones as estrogenic agents
US6884814B2 (en) * 2001-12-13 2005-04-26 Wyeth Phenyl benzisoxazoles as estrogenic agents
US6960607B2 (en) * 2001-12-13 2005-11-01 Wyeth Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
TW200301107A (en) * 2001-12-13 2003-07-01 Wyeth Corp Substituted 6H-dibenzo[c,h]chromenes as estrogenic agents
US6914074B2 (en) * 2001-12-13 2005-07-05 Wyeth Substituted phenyl naphthalenes as estrogenic agents
US6774248B2 (en) * 2001-12-18 2004-08-10 Wyeth Substituted 2-phenyl benzofurans as estrogenic agents
US6835745B2 (en) * 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents
KR100434149B1 (ko) * 2002-03-14 2004-06-04 엘지산전 주식회사 위치 결정 모듈의 동시 기동 장치
CL2004000985A1 (es) * 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
MXPA06012705A (es) * 2004-05-04 2007-03-26 Acadia Pharm Inc Compuestos con actividad en receptor de estrogeno.
CA2641116A1 (en) * 2006-02-14 2007-08-23 Wyeth Aqueous pharmaceutical formulations of er.beta. selective ligands

Also Published As

Publication number Publication date
CN101600421A (zh) 2009-12-09
AU2008210528A1 (en) 2008-08-07
WO2008094976A3 (en) 2008-11-06
WO2008094976A2 (en) 2008-08-07
MX2009008121A (es) 2009-08-12
JP2010516819A (ja) 2010-05-20
EP2112926A2 (en) 2009-11-04
TW200838509A (en) 2008-10-01
AR065104A1 (es) 2009-05-13
US20080182872A1 (en) 2008-07-31
CA2676553A1 (en) 2008-08-07
CL2008000308A1 (es) 2008-08-08
BRPI0807429A2 (pt) 2014-07-22

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