PE20080972A1 - Inhibidores de rho cinasa - Google Patents

Inhibidores de rho cinasa

Info

Publication number
PE20080972A1
PE20080972A1 PE2007001317A PE2007001317A PE20080972A1 PE 20080972 A1 PE20080972 A1 PE 20080972A1 PE 2007001317 A PE2007001317 A PE 2007001317A PE 2007001317 A PE2007001317 A PE 2007001317A PE 20080972 A1 PE20080972 A1 PE 20080972A1
Authority
PE
Peru
Prior art keywords
quinazolin
phenyl
alkyl
kinase inhibitors
rho kinase
Prior art date
Application number
PE2007001317A
Other languages
English (en)
Inventor
Siya Ram
Paul Sweetnam
Martin Hauer-Jensen
Junru Wang
Alessandra Bartolozzi
Stewart Campbell
Bridget COLE
James Ellis
Hope Foudoulakis
Brian Kirk
Original Assignee
Surface Logix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surface Logix Inc filed Critical Surface Logix Inc
Publication of PE20080972A1 publication Critical patent/PE20080972A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES UN ANILLO AROMATICO DE 5-6 MIEMBROS QUE PUEDE ABARCAR 0-3 HETEROATOMOS SELECCIONADOS DE N, O Y S; R1 ES ARILO, NH-(ALQUILOC1-C6); -CONH2; ENTRE OTROS; R2 ES CN, HALO, HIDROXI; ENTRE OTROS; R3 ES CN, HIDROXI, AMINO, ENTRE TROS; R4 ES -O-CO2-(ALQUILO C1-C6), O-HETEROARIL, -O-CICLOALQUILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, -COOH, O-ARILO, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, CONH2, ENTRE OTROS; n ES 0-4; m ES 0-3; p ES 0-1. SON COMPUESTOS PREFERIDOS: 2-(3-(4-(1H-INDAZOL-5-ILAMINO)QUINAZOLIN-2IL)FENOXI)-N-ISOPROPILACETAMIDA; N-((3-(4-(1H-IDAZOL-5-ILAMINO)QUINAZOLIN-2-IL)FENIL)-2-MORFOLINOACETAMIDA; 6-(2-(DIMETILAMINO)ETOXI)-N-(1H-INDAZOL-5-IL)-7-METOXI-2-(3-(FENIL)FENIL)QUINAZOLIN-4-AMINA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE FIBROSIS O ENFERMEDADES CARDIOVASCULARES
PE2007001317A 2006-09-27 2007-10-16 Inhibidores de rho cinasa PE20080972A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84769406P 2006-09-27 2006-09-27
US85012506P 2006-10-05 2006-10-05
US85012706P 2006-10-05 2006-10-05

Publications (1)

Publication Number Publication Date
PE20080972A1 true PE20080972A1 (es) 2008-10-04

Family

ID=39344830

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001317A PE20080972A1 (es) 2006-09-27 2007-10-16 Inhibidores de rho cinasa

Country Status (3)

Country Link
CA (1) CA2700988A1 (es)
PE (1) PE20080972A1 (es)
WO (1) WO2008054599A2 (es)

Families Citing this family (40)

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US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
EP2526948A1 (en) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO kinase inhibitors
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
JP2012519732A (ja) * 2009-03-09 2012-08-30 サーフェイス ロジックス，インコーポレイティド Ｒｈｏキナーゼ阻害剤
CA2929545C (en) 2009-05-01 2019-04-09 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2011092695A1 (en) * 2010-01-28 2011-08-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Quinazoline-based t cell proliferation inhibitors
PT2903618T (pt) 2012-10-05 2022-08-19 Kadmon Corp Llc Inibidores de rho cinase
WO2014080291A2 (en) * 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
EP2935253B1 (en) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
EA201591746A1 (ru) 2013-03-14 2016-08-31 КОНВЕРДЖЕН ЭлЭлСи Способы и композиции для ингибирования бромодомен-содержащих белков
EP4335507A3 (en) 2013-03-15 2024-06-05 Aerie Pharmaceuticals, Inc. Combination therapy
ES2806135T3 (es) 2013-06-21 2021-02-16 Zenith Epigenetics Ltd Nuevos inhibidores de bromodominios bicíclicos
JP6599852B2 (ja) 2013-06-21 2019-10-30 ゼニス・エピジェネティクス・リミテッド ブロモドメイン阻害剤としての新規の置換された二環式化合物
CN105593224B (zh) 2013-07-31 2021-05-25 恒元生物医药科技(苏州)有限公司 作为溴结构域抑制剂的新型喹唑啉酮类化合物
WO2015054317A1 (en) 2013-10-07 2015-04-16 Kadmon Corporation, Llc Rho kinase inhibitors
CA2966298A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
US10179125B2 (en) 2014-12-01 2019-01-15 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
JP2017537946A (ja) 2014-12-11 2017-12-21 ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． ブロモドメイン阻害剤としての置換複素環
CA2966450A1 (en) 2014-12-17 2016-06-23 Olesya KHARENKO Inhibitors of bromodomains
WO2016160833A1 (en) * 2015-04-01 2016-10-06 Rigel Pharmaceuticals, Inc. TGF-β INHIBITORS
AU2015414743B2 (en) 2015-11-17 2019-07-18 Alcon Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
ES2918589T3 (es) 2015-11-25 2022-07-19 Convergene Llc Inhibidores de bromodomios BET bicíclicos y usos de los mismos
WO2019000682A1 (zh) 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
US11390609B2 (en) 2017-06-30 2022-07-19 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
CN110582491B (zh) 2017-06-30 2023-09-29 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
WO2019018562A1 (en) 2017-07-19 2019-01-24 Ideaya Biosciences, Inc. AMIDO COMPOUND AS MODULATORS OF AHR
CA3073956A1 (en) 2017-09-03 2019-03-07 Angion Biomedica Corp. Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors
US10815250B2 (en) 2018-02-06 2020-10-27 Ideaya Biosciences, Inc. AhR modulators
US11345678B2 (en) 2018-04-18 2022-05-31 Medshine Discovery Inc. Benzopyrazole compound used as RHO kinase inhibitor
US11702400B2 (en) 2019-10-18 2023-07-18 Medshine Discovery Inc. Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors
CN114746412A (zh) * 2019-12-27 2022-07-12 广东东阳光药业有限公司 Kd-025的新晶型及其制备方法
US12014835B2 (en) 2020-02-19 2024-06-18 Vanderbilt University Methods for evaluating therapeutic benefit of combination therapies
KR20230043910A (ko) 2020-07-22 2023-03-31 테바 파마슈티컬스 인터내셔널 게엠베하 벨루모수딜 및 벨루모수딜 염의 고체 상태 형태
WO2022229351A1 (en) * 2021-04-28 2022-11-03 Graviton Bioscience Bv Selective inhibitors of rock2 for the treatment of muscular dystrophy
US20240343712A1 (en) 2021-07-16 2024-10-17 Sandoz Ag Solid-state forms of 2-(3-(4-(1h-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-n-isopropylacetamide methane sulfonic acid salt
TW202423441A (zh) * 2022-10-13 2024-06-16 大陸商北京泰德製藥股份有限公司 治療塵肺病的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27225A1 (es) * 2001-03-23 2002-10-31 Bayer Corp Inhibidores de la rho-quinasa
US7645878B2 (en) * 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof

Also Published As

Publication number Publication date
WO2008054599A3 (en) 2008-11-20
WO2008054599A2 (en) 2008-05-08
CA2700988A1 (en) 2008-05-08

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