PE20080148A1 - NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT - Google Patents
NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING ITInfo
- Publication number
- PE20080148A1 PE20080148A1 PE2006000562A PE2006000562A PE20080148A1 PE 20080148 A1 PE20080148 A1 PE 20080148A1 PE 2006000562 A PE2006000562 A PE 2006000562A PE 2006000562 A PE2006000562 A PE 2006000562A PE 20080148 A1 PE20080148 A1 PE 20080148A1
- Authority
- PE
- Peru
- Prior art keywords
- agomelatin
- hydrogen
- formula
- compound
- new
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFEIRE A UN PROCESO PARA LA SINTESIS INDUSTRIAL DE AGOMELATINA O N-[2-(7-METOXI-1-NAFTIL)ETIL]ACETAMIDA DE FORMULA (I), QUE COMPRENDE EN HACER REACCIONAR 7-METOXI-1-TETRALONA CON ACIDO CIANOACETICO EN CONDICIONES EN QUE SE REMUEVE EL AGUA FORMADA, EN PRESENCIA DE UNA CANTIDAD CATALITICA DE UN COMPUESTO DE FORMULA (V), EN DONDE R Y R' SON INDEPENDIENTEMENTE ALQUILO(C3-C10), ARILO, ALQUIL(C1-C6)ARILO, ENTRE OTROS; PARA PRODUCIR (7-METOXI-3,4-DIHIDRO-1-NAFTALENIL)ACETONITRILO EL CUAL SE HACE REACCIONAR CON UN CATALIZADOR DE HIDROGENACION EN PRESENCIA DE UN COMPUESTO DE ALILO PAR LUEGO SOMETERLO A REDUCCION CON HIDROGENO Y POSTERIORMENTE CONVERTIRLO EN UNA SAL USANDO HCl, Y POSTERIORMENTE SE SOMETE A LA ACCION DE ACETATO DE SODIO Y LUEGO ANHIDRIDO ACETICO PARA PRODUCIR EL COMPUESTO DE FORMULA (I) QUE ES AISLADO EN FORMA SOLIDA. TAMBIEN SE REFIERE A UNA FORMA CRISTALINA II DE AGOMELATINA Y UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SUENO, ESTRES, ANSIEDAD O DEPRESIONIT REFERS TO A PROCESS FOR THE INDUSTRIAL SYNTHESIS OF AGOMELATIN OR N- [2- (7-METOXY-1-NAPHTHYL) ETHYL] ACETAMIDE OF FORMULA (I), WHICH INCLUDES IN REACTING 7-METHOXY-1-TETRALONE WITH CYANOACETIC ACID UNDER CONDITIONS IN WHICH WATER FORMED IS REMOVED, IN THE PRESENCE OF A CATALYTIC AMOUNT OF A COMPOUND OF FORMULA (V), WHERE RYR 'ARE INDEPENDENTLY ALKYL (C3-C10), ARYL, ALKYL (C1-C6) ARYL, AMONG OTHERS ; TO PRODUCE (7-METOXY-3,4-DIHYDRO-1-NAPHTHALENYL) ACETONITRILE, WHICH IS REACTED WITH A HYDROGENATION CATALYST IN THE PRESENCE OF AN ALLYL COMPOUND, THEN SUBMITTING IT TO REDUCTION WITH HYDROGEN WITH A SALT WITH HYDROGEN AND SUBSEQUENTLY USING HYDROGEN , AND THEN SUBJECT TO THE ACTION OF SODIUM ACETATE AND THEN ACETIC ANHYDRIDE TO PRODUCE THE COMPOUND OF FORMULA (I) WHICH IS ISOLATED IN SOLID FORM. IT ALSO REFERS TO A CRYSTALLINE II FORM OF AGOMELATIN AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT BEING USEFUL IN THE TREATMENT OF DISORDERS OF SLEEP, STRESS, ANXIETY OR DEPRESSION
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PE2006000562A PE20080148A1 (en) | 2006-05-30 | 2006-05-30 | NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PE2006000562A PE20080148A1 (en) | 2006-05-30 | 2006-05-30 | NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080148A1 true PE20080148A1 (en) | 2008-03-29 |
Family
ID=43217095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000562A PE20080148A1 (en) | 2006-05-30 | 2006-05-30 | NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
Country Status (1)
Country | Link |
---|---|
PE (1) | PE20080148A1 (en) |
-
2006
- 2006-05-30 PE PE2006000562A patent/PE20080148A1/en not_active Application Discontinuation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2564250T3 (en) | New process for statins and their pharmaceutically acceptable salts thereof | |
US7632864B2 (en) | Gabapentin analogues and process thereof | |
AR047741A1 (en) | A PROCEDURE FOR THE INDUSTRIAL SYNTHESIS OF AGOMELATIN, OR N- [2- (7-METOXI-1-NAFTIL) ETHYL] ACETAMIDE, ITS CRYSTALINE FORM II AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | |
ES2658221T3 (en) | Compounds useful in the synthesis of benzamide compounds | |
UA109774C2 (en) | CRYSTAL FORMS OF SAXAGLIPTIN AND ITS PROCESS (OPTIONS) | |
PE20050948A1 (en) | CARBAMOIL-AMINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | |
UY30649A1 (en) | BIARIL ÉTER UREA COMPOUNDS | |
MX2014001144A (en) | General method for preparing fatty acyl amido based surfactants. | |
DE602006008962D1 (en) | PROCESS FOR PREPARING VALSARTAN | |
KR100974608B1 (en) | Method of producing 3-o-alkyl-5,6-o-1-methylethylidene-l-ascorbic acid and method of producing 5,6-o-1-methylethylidene-l-ascorbic acid | |
US8835672B2 (en) | Manufacture of a triiodinated contrast agent | |
PE20080148A1 (en) | NEW PROCESS FOR SYNTHESIS AND NEW CRYSTAL FORM OF AGOMELATIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | |
JPWO2009057199A1 (en) | Retinoid prodrug compounds | |
JP6054875B2 (en) | Process for the preparation of aromatic thiol derivatives by hydrogenation of disulfides. | |
CN103435526A (en) | Synthesis method of vildagliptin | |
ATE438612T1 (en) | NOVEL PROCESS FOR PRODUCING QUATERNARY ACID AND AMMONIUM SALTS | |
CN102807516A (en) | Intermediate in amisulpride and method for preparing amisulpride by using intermediate | |
WO2012117410A1 (en) | A process for the preparation of n-[2-[(acetylthio) methyl]-1-oxo-3-phenylpropyl] glycine phenyl methyl ester and intermediates thereof | |
ES2397246T3 (en) | Procedure for purifying 5-amino-N, N'-bis (2,3-dihydroxypropyl) -isophthalamide, an intermediate in the preparation of non-ionic X-ray contrast agents | |
CA2959387A1 (en) | Synthesis of cyclocreatine and analogs thereof | |
HUP0302174A2 (en) | Process for the preparation of chirally pure n-(trans-4-isopropyl-cyclohexylcarbonyl)-d-phenyl-alanine (nateglinide) and it's crystalline forms and the cristalline form g | |
AU721099B2 (en) | Preparation of acylated alpha-amino carboxylic acid amides | |
JP5568137B2 (en) | Method for producing amino acid amide derivative having fluorine-containing carbamate group, production intermediate thereof, and method for producing ethylenediamine derivative | |
PE20030741A1 (en) | SUBSTITUTE IMIDAZOLIDINES AND PROCEDURES FOR THEIR PREPARATION | |
CA2570255A1 (en) | 4-t-butylgabapentin and its synthesis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |