PE20080012A1 - DERIVATIVES OF INDOLE AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE - Google Patents

DERIVATIVES OF INDOLE AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE

Info

Publication number
PE20080012A1
PE20080012A1 PE2007000335A PE2007000335A PE20080012A1 PE 20080012 A1 PE20080012 A1 PE 20080012A1 PE 2007000335 A PE2007000335 A PE 2007000335A PE 2007000335 A PE2007000335 A PE 2007000335A PE 20080012 A1 PE20080012 A1 PE 20080012A1
Authority
PE
Peru
Prior art keywords
cycloalkyl
phenyl
methyl
inhibitors
indol
Prior art date
Application number
PE2007000335A
Other languages
Spanish (es)
Inventor
Bernd Buchmann
Dirk Kosemund
Bernd Menzenbach
Fritsch Martin
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20080012A1 publication Critical patent/PE20080012A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE INDOL DE FORMULA (I), DONDE R1 ES H, CF3, CICLOALQUILO C3-C6, ENTRE OTROS; R2 ES H, HALOGENO, CICLOALQUILO C3-C6, ENTRE OTROS; R3 ES ARILO C6-C12, HETEROARILO DE 5 A 12 MIEMBROS, CICLOALQUILO C3-C6, ENTRE OTROS; R4 ES H, CICLOALQUILO C3-C6, ARILO C6-C12, ENTRE OTROS; R5 ES H, CICLOALQUILO C3-C6, ARILO C6-C12, ENTRE OTROS; R6 ES ALQUILO C1-C6, ACILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2-MORFOLIN-4-IL-ETIL)-AMIDA DE ACIDO 5-[(4-TER-BUTIL-FENILSULFONIL)-METIL-AMINO]-3-FENIL-1H-INDOL-2-CARBOXILICO, (2-HIDROXI-1-METIL-ETIL)-AMIDA DE ACIDO (±)-5-[(4-TER-BUTIL-FENILSULFONIL)-METIL-AMINO]-3-FENIL-1H-INDOL-2-CARBOXILICO, (PIRIDIN-4-IL)-AMIDA DE ACIDO 5-[(4-TER-BUTIL-FENIL-SULFONIL)-METIL-AMINO]-3-FENIL-1H-INDOL-2-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ADENILATO CICLASA SOLUBLE Y SON UTILES EN LA REGULACION DE LA FERTILIDAD MASCULINAREFERRING TO A COMPOUND DERIVED FROM INDEOL OF FORMULA (I), WHERE R1 IS H, CF3, C3-C6 CYCLOALKYL, AMONG OTHERS; R2 IS H, HALOGEN, C3-C6 CYCLOALKYL, AMONG OTHERS; R3 IS C6-C12 ARYL, 5 TO 12-MEMBER HETEROARYL, C3-C6 CYCLOALKYL, AMONG OTHERS; R4 IS H, C3-C6 CYCLOALKYL, C6-C12 ARYL, AMONG OTHERS; R5 IS H, C3-C6 CYCLOALKYL, C6-C12 ARYL, AMONG OTHERS; R6 IS C1-C6 ALKYL, C1-C6 ACIL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (2-MORPHOLIN-4-IL-ETHYL) -AMIDE OF ACID 5 - [(4-TER-BUTYL-PHENYLSULFONYL) -METHYL-AMINO] -3-PHENYL-1H-INDOL-2-CARBOXYL, ( 2-HYDROXY-1-METHYL-ETHYL) -ACID AMIDE (±) -5 - [(4-TER-BUTYL-PHENYLSULFONYL) -METHYL-AMINO] -3-PHENYL-1H-INDOL-2-CARBOXYL, (PYRIDIN -4-IL) -AMIDE OF ACID 5 - [(4-TER-BUTYL-PHENYL-SULFONIL) -MEthyl-AMINO] -3-PHENYL-1H-INDOL-2-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE INHIBITORS OF SOLUBLE ADENYLATE CYCLASE AND ARE USEFUL IN THE REGULATION OF MALE FERTILITY

PE2007000335A 2006-03-23 2007-03-23 DERIVATIVES OF INDOLE AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE PE20080012A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006014320A DE102006014320B4 (en) 2006-03-23 2006-03-23 Inhibitors of the soluble adenylate class

Publications (1)

Publication Number Publication Date
PE20080012A1 true PE20080012A1 (en) 2008-04-03

Family

ID=38229991

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000335A PE20080012A1 (en) 2006-03-23 2007-03-23 DERIVATIVES OF INDOLE AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE

Country Status (12)

Country Link
EP (1) EP2001847A2 (en)
JP (1) JP2009531319A (en)
KR (1) KR20090007351A (en)
CN (1) CN101448789A (en)
AR (1) AR063661A1 (en)
CA (1) CA2646650A1 (en)
DE (1) DE102006014320B4 (en)
DO (1) DOP2007000059A (en)
PE (1) PE20080012A1 (en)
TW (1) TW200815347A (en)
UY (1) UY30236A1 (en)
WO (1) WO2007107385A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2036906A1 (en) * 2007-09-05 2009-03-18 Bayer Schering Pharma Aktiengesellschaft Azaindoles as inhibitors of soluble adenylate cyclase
CN108096244B (en) * 2018-01-25 2020-11-24 昆明医科大学 Application of 1-hydrogen-2-indolone-3-benzyl/substituted benzyl-3-formate compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
AU2005265270B2 (en) * 2004-06-22 2011-09-22 Vertex Pharmaceuticals Incorporated Heterocyclic derivatives for modulation of calcium channels
DE102004047272A1 (en) * 2004-09-24 2006-04-06 Schering Ag Inhibitors of soluble adenylate cyclase

Also Published As

Publication number Publication date
CN101448789A (en) 2009-06-03
KR20090007351A (en) 2009-01-16
JP2009531319A (en) 2009-09-03
DOP2007000059A (en) 2007-09-30
CA2646650A1 (en) 2007-09-27
WO2007107385A2 (en) 2007-09-27
EP2001847A2 (en) 2008-12-17
TW200815347A (en) 2008-04-01
DE102006014320A1 (en) 2007-09-27
AR063661A1 (en) 2009-02-11
DE102006014320B4 (en) 2009-01-22
UY30236A1 (en) 2007-10-31
WO2007107385A3 (en) 2007-11-29

Similar Documents

Publication Publication Date Title
RS53226B (en) Novel phenylimidazole derivatives as pde10a enzyme inhibitors
RS53080B (en) Aminophosporic acid ester derivative and s1p receptor modulator containing the same as active ingredient
RS52099B (en) Substituted benzimidazoles as kinase inhibitors
HRP20070430T3 (en) (3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity
TW200745029A (en) Sulfonamide derivatives exhibiting PGD2 receptor antagonism
MX2009003939A (en) Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes.
RS52605B (en) Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors
TNSN06338A1 (en) Substantially pure 2-{[2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carbonyl]-amino}-3-(phenylpyridin-2-yl-amino)-propionic acid as an ikb kinase inhibitor
HRP20110841T1 (en) Useful monobactam antibiotics
PE20060777A1 (en) INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
RS54260B1 (en) Aminodihydrothiazine derivatives as bace inhibitors for the treatment of alzheimer's disease
RS53830B1 (en) Oxazole substituted indazoles as pi3-kinase inhibitors
RS54202B1 (en) Quinoline and quinoxaline derivatives as kinase inhibitors
PE20090880A1 (en) HETEROCYCLIC COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
DK1856045T3 (en) 1-acetic acid indole derivatives with PGD2 antagonist effect
PE20080835A1 (en) NOVEL AMINOPYRIDINE DERIVATIVES WHICH HAVE SELECTIVE INHIBITOR ACTION ON AURORA A
PE20081354A1 (en) AZAINDOLYL COMPOUNDS AS MEK INHIBITORS
PE20100093A1 (en) ACETYLENE DERIVATIVES
TW200745097A (en) 4-Phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors
EA200400994A1 (en) NEW 1,2,3-SUBSTITUTED INDOLYSINE DERIVATIVES THAT ARE INHIBITORS OF FIBROBLAST GROWTH FACTORS, METHOD OF THEIR RECEIVING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CO6260066A2 (en) DERIVATIVES OF AZETIDINE AND ITS USE AS ANTAGONISTS OF PROSTAGLANDINA E2
NO20065863L (en) 3- [4- (6- (4,5-Dihydroisoxazol-3-yl) pyridin-3-yl) -3-phenyl] -5- (1H, 1,2,3-triazol-1-yl-methyl) ) -1,3-oxazolidin-2-ones as antibacterial agents
PE20060696A1 (en) SOLUBLE ADENYLATE CYCLASE INHIBITORS
PE20091079A1 (en) HETEROCYCLIC COMPOUNDS AS NPY Y2 MODULATORS
PE20080012A1 (en) DERIVATIVES OF INDOLE AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE

Legal Events

Date Code Title Description
FC Refusal