PE20071039A1 - Derivados de quinolizinona o piridazinona como agentes inhibidores de quinasa p38 - Google Patents
Derivados de quinolizinona o piridazinona como agentes inhibidores de quinasa p38Info
- Publication number
- PE20071039A1 PE20071039A1 PE2006001531A PE2006001531A PE20071039A1 PE 20071039 A1 PE20071039 A1 PE 20071039A1 PE 2006001531 A PE2006001531 A PE 2006001531A PE 2006001531 A PE2006001531 A PE 2006001531A PE 20071039 A1 PE20071039 A1 PE 20071039A1
- Authority
- PE
- Peru
- Prior art keywords
- difluorophenoxy
- pyridazin
- pyrido
- hydrogen
- quinolizinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE QUINOLIZINONA O PIRIDAZINONA DE FORMULA (I), DONDE A SE SELECCIONA DE -CH Y N; W SE SELECCIONA DE -Cra- Y N ; X ESTA AUSENTE O ES O, ALQUILO C1-C4, S(O)n, ALQUENO C2-C6, C(O), ENTRE OTROS; Ra ES HIDROGENO, ALQUILO C1-C6, ALCOXI C1-C6, CONH2, ENTRE OTROS; R1, R2 Y R3 SON HIDROGENO, ALCOXI C1-C6, CICLOALQUILO C3-C6, HALOGENO, ENTRE OTROS; R4 ES ARILO, HIDROGENO, HALOGENO, HETEROARILO, CICLOALQUILO C3-C6, ENTRE OTROS; m ES 0, 1, 2 O 3; n ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 2-(2,4-DIFLUOROFENOXI)-5-[2-METOXI-5-(5-METIL-1,3,4-OXADIAZOL-2-IL)FENIL]-6H-PIRIDO[1,2-b]PIRIDAZIN-6-ONA, N-CICLOPROPIL-3-[2-(2,4-DIFLUOROFENOXI)-6-OXO-6H-PIRIDO[1,2-b]PIRIDAZIN-5-IL]-4-METOXIBENZAMIDA, 3-[2-(2,4-DIFLUOROFENOXI)-6-OXO-6H-PIRIDO[1,2-b]PIRIDAZIN-5-IL]-4-METOXI-N-PROPILBENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA ACTIVADA POR MITOGENOS p38 (MAP p38) Y SON UTILES EM EL TRATAMIENTO DE SEPTICEMIA, ALARIA CEREBRAL, ENFERMEDAD INFLAMATORIA PULMONAR CRONICA, ENFERMEDAD DE RESORCION OSEA TALES COMO OSTEOPOROSIS, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74222505P | 2005-12-05 | 2005-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071039A1 true PE20071039A1 (es) | 2007-11-30 |
Family
ID=38016560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001531A PE20071039A1 (es) | 2005-12-05 | 2006-11-30 | Derivados de quinolizinona o piridazinona como agentes inhibidores de quinasa p38 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7482345B2 (es) |
| EP (1) | EP1963314A2 (es) |
| JP (1) | JP2009518401A (es) |
| AR (1) | AR056241A1 (es) |
| AU (1) | AU2006322033A1 (es) |
| CA (1) | CA2631794A1 (es) |
| DO (1) | DOP2006000272A (es) |
| PE (1) | PE20071039A1 (es) |
| TW (1) | TW200806663A (es) |
| WO (1) | WO2007067478A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
| WO2020108659A1 (zh) * | 2018-11-30 | 2020-06-04 | 上海医药集团股份有限公司 | 含氮杂环类化合物及其组合物、制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0294599A3 (de) | 1987-06-12 | 1990-05-09 | F. Hoffmann-La Roche Ag | Tricyclische Pyridonderivate |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| JP4758349B2 (ja) | 2003-10-08 | 2011-08-24 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| JP5113751B2 (ja) | 2005-08-12 | 2013-01-09 | メルク・シャープ・エンド・ドーム・コーポレイション | ｐ３８キナーゼ阻害剤として有用な二環性複素環化合物 |
| AU2006307101A1 (en) * | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase |
| TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| US20070117839A1 (en) * | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
-
2006
- 2006-11-21 US US11/602,782 patent/US7482345B2/en not_active Expired - Fee Related
- 2006-11-28 TW TW095144024A patent/TW200806663A/zh unknown
- 2006-11-30 PE PE2006001531A patent/PE20071039A1/es not_active Application Discontinuation
- 2006-12-01 AR ARP060105323A patent/AR056241A1/es not_active Application Discontinuation
- 2006-12-01 AU AU2006322033A patent/AU2006322033A1/en not_active Abandoned
- 2006-12-01 JP JP2008544412A patent/JP2009518401A/ja not_active Withdrawn
- 2006-12-01 WO PCT/US2006/046217 patent/WO2007067478A2/en active Application Filing
- 2006-12-01 EP EP06844775A patent/EP1963314A2/en not_active Withdrawn
- 2006-12-01 CA CA002631794A patent/CA2631794A1/en not_active Abandoned
- 2006-12-01 US US12/085,419 patent/US20090088436A1/en not_active Abandoned
- 2006-12-05 DO DO2006000272A patent/DOP2006000272A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009518401A (ja) | 2009-05-07 |
| US20070129372A1 (en) | 2007-06-07 |
| US7482345B2 (en) | 2009-01-27 |
| DOP2006000272A (es) | 2007-07-31 |
| CA2631794A1 (en) | 2007-06-14 |
| US20090088436A1 (en) | 2009-04-02 |
| AR056241A1 (es) | 2007-09-26 |
| AU2006322033A1 (en) | 2007-06-14 |
| EP1963314A2 (en) | 2008-09-03 |
| TW200806663A (en) | 2008-02-01 |
| WO2007067478A2 (en) | 2007-06-14 |
| WO2007067478A3 (en) | 2007-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |