PE20070719A1 - Derivados de naftiridina como inhibidores de la actividad de la akt - Google Patents

Derivados de naftiridina como inhibidores de la actividad de la akt

Info

Publication number
PE20070719A1
PE20070719A1 PE2006001351A PE2006001351A PE20070719A1 PE 20070719 A1 PE20070719 A1 PE 20070719A1 PE 2006001351 A PE2006001351 A PE 2006001351A PE 2006001351 A PE2006001351 A PE 2006001351A PE 20070719 A1 PE20070719 A1 PE 20070719A1
Authority
PE
Peru
Prior art keywords
phenyl
inhibitors
triazolo
piperidin
pyridin
Prior art date
Application number
PE2006001351A
Other languages
English (en)
Inventor
Michael J Kelly Iii
Essa H Hu
Yiwei Li
Jun Liang
Michael A Rossi
Jiabing Wang
Mark E Layton
Kevin J Rodzinark
Philip E Sanderson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/022079 external-priority patent/WO2006135627A2/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20070719A1 publication Critical patent/PE20070719A1/es

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE NAFTIRIDINA DE FORMULA A DONDE a ES 0 O 1; b ES 0 O 1; m ES 0, 1 O 2; Q ES UN HETEROCICLILO TAL COMO TRIAZOL O IMIDAZOL, ENTRE OTROS; R1 ES H, OXO, HALO, COOH, OH, (C=O)aObALQUILO C1-C10, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 9-FENIL-8-(4-{[4-(5-PIRIDIN-2-IL)-1H-1,2,4-TRIAZOL-3-IL))PIPERIDIN-1-IL)]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDIN-3-AMINA, 9-FENIL-8-(4-{[ 4-(5-PIRIDIN-2-IL-1H-1,2,4-TRIAZOL-3-IL))PIPERIDIN-1-IL]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDIN-3-OL, 3-(CLOROMETIL)-9-FENIL-8-(4-{[4-(4-PIRIDIN-2-IL-1H-IMIDAZOL-1-IL)PIPERIDIN-1-IL]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA SERINA/TREONINA QUINASA Akt Y SON UTILES PARA EL TRATAMIENTO DE CANCER
PE2006001351A 2005-11-07 2006-11-03 Derivados de naftiridina como inhibidores de la actividad de la akt PE20070719A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73418805P 2005-11-07 2005-11-07
PCT/US2006/022079 WO2006135627A2 (en) 2005-06-10 2006-06-07 Inhibitors of akt activity

Publications (1)

Publication Number Publication Date
PE20070719A1 true PE20070719A1 (es) 2007-08-10

Family

ID=38951408

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001351A PE20070719A1 (es) 2005-11-07 2006-11-03 Derivados de naftiridina como inhibidores de la actividad de la akt

Country Status (4)

Country Link
AR (1) AR057843A1 (es)
DO (1) DOP2006000242A (es)
GT (1) GT200600476A (es)
PE (1) PE20070719A1 (es)

Also Published As

Publication number Publication date
DOP2006000242A (es) 2007-12-15
GT200600476A (es) 2007-05-23
AR057843A1 (es) 2007-12-19

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed